Extracorperal ultrasonic irradition of titanium oxide (TiO2) coated implant for angiogenesis stimulation
First Claim
1. A method of stimulating angiogenesis of a tissue in the vicinity of an implantable medical device by use of an ultrasonic medical apparatus including an ultrasonic irradiation means including a transducer, the method comprising the steps of:
- implanting, into a body, the implantable medical device whose surface has been covered with a titanium oxide material; and
extracorporeally irradiating, by use of the ultrasonic irradiation means including the transducer, with ultrasonic waves, the titanium oxide material provided on the surface of the implantable medical device thus implanted,the titanium oxide material being a titanium oxide composite material produced by covering a surface of a polymer base material with titanium oxide,the titanium oxide composite material being composed of (a) a polymer base material having an active group and (b) titanium oxide having a reactive functional group capable of reacting with the active group, andthe titanium oxide composite material being produced through chemical bonding between the active group and the reactive functional group.
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Accused Products
Abstract
The present invention solves the issue of bacterial infection by medical devices such as intracorporeal indwelling catheters. The present invention relates to an ultrasonic medical apparatus including a medical device (titanium oxide coated medical device 10) covered with a titanium oxide material (titanium oxide alone or a titanium oxide composite material) and ultrasonic irradiation means 20. Ultrasonic irradiation of the titanium oxide material, which exists on a surface of the medical device, causes the surface of the medical device to exert beneficial effects such as antibiotic action, the stimulation of angiogenesis, and the degradation of a blood clot and a biofilm.
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Citations
14 Claims
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1. A method of stimulating angiogenesis of a tissue in the vicinity of an implantable medical device by use of an ultrasonic medical apparatus including an ultrasonic irradiation means including a transducer, the method comprising the steps of:
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implanting, into a body, the implantable medical device whose surface has been covered with a titanium oxide material; and extracorporeally irradiating, by use of the ultrasonic irradiation means including the transducer, with ultrasonic waves, the titanium oxide material provided on the surface of the implantable medical device thus implanted, the titanium oxide material being a titanium oxide composite material produced by covering a surface of a polymer base material with titanium oxide, the titanium oxide composite material being composed of (a) a polymer base material having an active group and (b) titanium oxide having a reactive functional group capable of reacting with the active group, and the titanium oxide composite material being produced through chemical bonding between the active group and the reactive functional group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification