Tissue oxygenation monitoring in heart failure
First Claim
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1. A method for controlling a therapy in a patient, comprising;
- sensing an activity sensor signal;
detecting a change in activity level of the patient from the activity sensor signal;
sensing an optical sensor signal corresponding to tissue light attenuation in a tissue volume;
computing a tissue oxygenation measurement from the optical sensor signal in response to detecting the change in activity level, the tissue oxygenation measurement comprising contributions from arterial and venous blood in a measurement volume, wherein computing the tissue oxygenation measurement comprises computing a trend;
detecting a decrease in tissue oxygenation in response to the tissue oxygenation measurement, wherein detecting a decrease in the tissue oxygenation measurement comprises;
defining a plurality of thresholds for each one of a respective plurality of activity levels,selecting one of the plurality of thresholds in response to detecting the change in activity; and
comparing the tissue oxygenation measurement and the selected one of the plurality of thresholds; and
adjusting a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation.
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Abstract
A medical device system and associated method control the delivery of a therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the therapy is adjusted in response to detecting the decreased tissue oxygenation.
108 Citations
23 Claims
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1. A method for controlling a therapy in a patient, comprising;
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sensing an activity sensor signal; detecting a change in activity level of the patient from the activity sensor signal; sensing an optical sensor signal corresponding to tissue light attenuation in a tissue volume; computing a tissue oxygenation measurement from the optical sensor signal in response to detecting the change in activity level, the tissue oxygenation measurement comprising contributions from arterial and venous blood in a measurement volume, wherein computing the tissue oxygenation measurement comprises computing a trend; detecting a decrease in tissue oxygenation in response to the tissue oxygenation measurement, wherein detecting a decrease in the tissue oxygenation measurement comprises; defining a plurality of thresholds for each one of a respective plurality of activity levels, selecting one of the plurality of thresholds in response to detecting the change in activity; and comparing the tissue oxygenation measurement and the selected one of the plurality of thresholds; and adjusting a parameter controlling delivery of the therapy in response to detecting the decreased tissue oxygenation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A medical device system for delivering a therapy to a patient, comprising:
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a controller to set a therapy delivery control parameter; an optical sensor to produce a signal corresponding to tissue light attenuation; an activity sensor to produce a signal correlated to an activity level of a patient; a memory to store a plurality of thresholds for each one of a respective plurality of activity levels; a processor configured to compute an activity measurement from the activity sensor signal, detect a change in activity in response to the activity measurement, compute a tissue oxygenation measurement from the optical sensor signal in response to detecting the change in activity, and detect a decrease in tissue oxygenation in response to the computed tissue oxygenation measurement, the tissue oxygenation measurement comprising contributions from arterial and venous blood in a measurement volume, wherein computing the tissue oxygenation measurement comprises computing a trend, wherein detecting the decrease in tissue oxygenation comprises; selecting one of the plurality of thresholds in response to detecting the change in activity; and comparing the tissue oxygenation measurement and the selected one of the plurality of thresholds, and wherein the controller adjusts the control parameter in response to the processor detecting the decreased tissue oxygenation. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A non-transitory computer readable medium having computer executable instructions for performing a method comprising:
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sensing an activity sensor signal; detecting a change in activity level of the patient from the activity sensor signal; sensing an optical sensor signal corresponding to tissue light attenuation; computing a tissue oxygenation measurement from the optical sensor signal in response to detecting the change in activity level, the tissue oxygenation measurement comprising contributions from arterial and venous blood in a measurement volume, wherein computing the tissue oxygenation measurement comprises computing a trend; detecting a decrease in tissue oxygenation in response to the tissue oxygenation measurement, wherein detecting a decrease in the tissue oxygenation measurement comprises; defining a plurality of thresholds for each one of a respective plurality of activity levels, selecting one of the plurality of thresholds in response to detecting the change in activity; and comparing the tissue oxygenation measurement and the selected one of the plurality of thresholds; and adjusting a parameter controlling delivery of a therapy in response to detecting the decreased tissue oxygenation.
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Specification