Electronically and remotely controlled pill and system for delivering at least one medicament

• US 8,518,022 B2
• Filed: 08/24/2005
• Issued: 08/27/2013
• Est. Priority Date: 08/27/2004
• Status: Active Grant

• Current Assignee: Biora Therapeutics Incorporated
• Original Assignee: Medimetrics Personalized Drug Delivery B.V.
• Inventors: Trovato, Karen I., Spekowius, Gerhard
• Primary Examiner(s): Stigell, Theodore
• Assistant Examiner(s): Matney, Brooke
• Application Number:
  US11/574,200
• Publication Number:
  US 20070213659A1
• Time in Patent Office: 2,925 Days
• Field of Search: 604/67, 604/516, 604/890.1, 604/65, 604/66, 604/95.01, 604/113, 604/114, 604/30, 604/31, 604/151, 604/48, 604/500, 604/103.01
• US Class Current: 604/890.1
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

An electronically and remotely controlled pill (500) or medicament delivery system is provided. The pill (500) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens and closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108). RF communication circuitry receives control signals for remotely overriding the preset dispensing timing pattern, reprogramming the control and timing circuitry (108), or terminating the dispensing of the medicament within the body. The pill (500) includes an RFID tag (508) for tracking, identification, inventory and other purposes.

Claims

1. A medicament delivery system for dispensing a medicament while traversing the gastrointestinal tract, the system comprising:

a housing;

a reservoir for storing the medicament within the housing;

a valve in fluid communication with the reservoir;

control and timing circuitry for controlling the valve independent of a sensed physiological parameter of the gastrointestinal tract by applying a signal to the valve for opening and closing the valve for dispensing the medicament, in accordance with the applied signal wherein the control and timing circuitry is programmed with a dispensing timing pattern, and wherein the medicament is dispensed substantially according to the dispensing timing pattern;

a pressure mechanism within the housing urging the medicament in the reservoir against the valve; and

means for remotely transmitting commands to the control and timing circuitry.

2. The system according to claim 1, wherein the means for remotely transmitting commands includes at least one antenna and RF communication circuitry for receiving RF control signals instructing the system to perform an action, and wherein the action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of the medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing the medicament according to a person'"'"'s vitals.

3. The system according to claim 2, further comprising a soluble membrane encapsulating the at least one antenna.

4. The system according to claim 1, wherein the means for remotely transmitting commands includes a piezo-electric element capable of being vibrated at at least one predetermined frequency.

5. The system according to claim 4, further comprising a data structure for correlating the at least one predetermined frequency with an action, and wherein the action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of the medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing the medicament according to a person'"'"'s vitals.

6. The system according to claim 1, further comprising a transmitter.

7. The system according to claim 1, further comprising an RFID tag.

8. The system according to claim 1, wherein the control and timing circuitry comprises a start timer mechanism, timing circuitry, and a release controller, wherein the start timer mechanism transmits a signal to the timing circuitry for clocking a dispensing time period, and wherein the timing circuitry transmits a signal to the release controller for controlling the valve for dispensing the medicament substantially according to the dispensing timing pattern during the dispensing time period.

9. The system according to claim 1, wherein the dispensing timing pattern correlates an approximate quantity of the medicament to be dispensed during each moment of time during a dispensing time period.

10. The system according to claim 1, further comprising another reservoir for storing another medicament.

11. The system according to claim 1, further comprising a dosage management system for relaying commands to the means for remotely transmitting commands for controlling the dispensing of the medicament in accordance with pre-obtained information selected from the group consisting of weather information, barometric reading, pollen count information and patient-related information.

12. The system according to claim 1, further comprising communication means for communicating with an imaging system, wherein the medicament is dispensed in synchronization with the imaging system.

13. A medicament treatment kit comprising:

a container enclosing a plurality of medicament delivery systems for delivering a medicament while traversing the gastrointestinal tract, wherein each system comprises;

a housing;

a reservoir for storing the medicament within the housing;

a valve in fluid communication with the reservoir;

control and timing circuitry for controlling the valve by applying a signal to the valve for opening and closing the valve for dispensing the medicament, in accordance with the applied signal wherein the control and timing circuitry is programmed with a dispensing timing pattern, and wherein the medicament is dispensed substantially according to the dispensing timing pattern; and

means for remotely transmitting commands to the control and timing circuitry;

a pressure mechanism disposed within the housing outside the reservoir and acting on the reservoir to maintain a pressure of the medicament in the reservoir against the valve; and

a schedule indicating when each of the medicament delivery systems is to be taken.

14. The kit according to claim 13, wherein the means for remotely transmitting includes at least one antenna and RF communication circuitry for receiving RF control signals instructing the system to perform an action, and wherein the action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of the medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing said medicament according to a person'"'"'s vitals.

15. The kit according to claim 14, further comprising a soluble membrane encapsulating the at least one antenna.

16. The kit according to claim 13, wherein the means for remotely transmitting includes a piezo-electric element capable of being vibrated at at least one predetermined frequency.

17. The kit according to claim 16, further comprising a data structure for correlating the at least one predetermined frequency with an action, and wherein the action is selected from the group consisting of reprogramming the control and timing circuitry with another dispensing timing pattern, terminating the dispensing of the medicament, dispensing another medicament, changing the dispensing timing pattern, and dispensing the medicament according to a person'"'"'s vitals.

18. The kit according to claim 13, wherein each system further comprises an RFID tag.

19. The kit according to claim 13, wherein the control and timing circuitry comprises a start timer mechanism, timing circuitry, and a release controller, wherein the start timer mechanism transmits a signal to the timing circuitry for clocking a dispensing time period, and wherein the timing circuitry transmits a signal to the release controller for controlling the valve for dispensing the medicament substantially according to the dispensing timing pattern during the dispensing time period.

20. The kit according to claim 13, wherein the dispensing timing pattern correlates an approximate quantity of the medicament to be dispensed during each moment of time during a dispensing time period.

21. The kit according to claim 13, further comprising another reservoir for storing another medicament.