Methods and apparatuses for coating a lesion
First Claim
1. A method to treat a vessel comprising:
- identifying a target region in a vessel comprising an artery;
delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon; and
coating the target region with the protein elastin-based polymer solution, wherein the porous balloon evenly distributes the solution onto walls of the artery, and wherein the porous balloon includes pores along the entire length of the porous balloon that touches the walls of the artery.
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Accused Products
Abstract
A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
13 Citations
50 Claims
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1. A method to treat a vessel comprising:
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identifying a target region in a vessel comprising an artery; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon; and coating the target region with the protein elastin-based polymer solution, wherein the porous balloon evenly distributes the solution onto walls of the artery, and wherein the porous balloon includes pores along the entire length of the porous balloon that touches the walls of the artery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 47)
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15. A method to treat a vessel comprising:
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identifying a target region in a vessel comprising an artery; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon, wherein the porous balloon includes pores along the entire length of the porous balloon that touches an inner wall of the artery; and coating the target region with the protein elastin-based polymer solution, wherein the protein elastin-based polymer further comprises triblock structure consisting of two flanking blocks and a middle block wherein each block further comprises at least one component, and wherein the protein triblock structure is of the general formula (VPGVG)4(VPGXGn(VPGVG)4), wherein X is selected from the group consisting of Lysine [SEQ ID NO. 60], arginine [SEQ ID NO. 12], glutamic acid [SEQ ID NO. 13], and aspartic acid [SEQ ID NO. 14].
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28. A method to treat a vessel comprising:
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identifying a target region in a vessel comprising an artery; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon, wherein the porous balloon includes pores along the entire length of the porous balloon that touches an inner wall of the artery; and coating the target region with the protein elastin-based polymer solution, wherein the protein elastin-based polymer further comprises triblock structure consisting of two flanking blocks and a middle block wherein each block further comprises at least one component, and wherein the triblock protein polymer is of the general formula (VPGVG)4(X) [SEQ ID NOS. 4-5], where X is selected from a group consisting of polyethylene glycol (PEG), poly(hydroxyethyl methacrylate) (polyHEMA), poly(vinyl pyrrolidinone) (PVP), and collagen.
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45. A method to treat a vessel comprising:
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identifying a target region in a vessel; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, wherein the delivery system comprises a porous balloon that includes pores along the entire length of the porous balloon that touches an inner wall of the artery, wherein the protein elastin-based polymer solution comprises a protein elastin-based polymer comprising a triblock structure including two flanking blocks and a middle block wherein a component within each block is selected from the group consisting of an amino acid, an amino acid sequence and a monomer and the middle block comprises a pendant group comprising a peptide sequence of YIGSRG [SEQ ID NO. 8]; and coating the target region with the protein elastin-based polymer solution.
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46. A method to treat a vessel comprising:
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identifying a target region in a vessel; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, wherein the delivery system comprises a porous balloon that includes pores along the entire length of the porous balloon that touches an inner wall of the artery, wherein the protein elastin-based polymer solution comprises a protein elastin-based polymer comprises a triblock structure including two flanking blocks and a middle block wherein a component within each flanking block is selected from the group consisting of an amino acid, an amino acid sequence and a monomer and the middle block comprises a peptide sequence of YIGSRG [SEQ ID NO. 8]; and coating the target region with the protein elastin-based polymer solution.
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48. A method to treat a vessel comprising:
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identifying a target region in a vessel comprising an artery; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon; and coating the target region with the protein elastin-based polymer solution, wherein the porous balloon forces the solution evenly into, and protectively coats the entire surface of a length and circumference of the inner wall of the artery, and wherein the porous balloon includes pores along the entire length of the porous balloon that touches the inner wall of the artery. - View Dependent Claims (49)
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50. A method to treat a vessel comprising:
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identifying a target region in a vessel comprising an artery; delivering a protein elastin-based polymer solution to the target region in the vessel using a delivery system, the delivery system comprising a catheter and a porous balloon; and coating the target region with the protein elastin-based polymer solution, wherein the porous balloon forces the solution evenly into, and protectively coats the entire surface of a length and circumference of the inner wall of the artery, wherein the porous balloon is rotated while forcing the solution evenly into the length and circumference, in order to protectively coat the entire surface of the length and circumference.
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Specification