Method of controlling diffusive sodium transport in dialysis

• US 8,518,260 B2
• Filed: 10/01/2010
• Issued: 08/27/2013
• Est. Priority Date: 10/01/2009
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Raimann, Jochen G., Penne, Erik Lars, Thijssen, Stephan, Kotanko, Peter, Levin, Nathan W.
• Primary Examiner(s): Kim, John
• Application Number:
  US12/896,009
• Publication Number:
  US 20110079558A1
• Time in Patent Office: 1,061 Days
• Field of Search: 210/645, 210/646, 210/647, 210/739, 210/746, 210/85, 210/86, 210/97, 210/103, 210/134, 210/143, 604/4.01, 604/5.01, 604/5.04, 604/28, 604/29
• US Class Current: 210/647
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1654 Dialysates therefor
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient

Abstract

A method of controlling diffusive sodium transport from the dialysate solution to the blood of a patient undergoing hemodialysis treatment or from the blood to the dialysate solution includes calculating SNa⁺_average, an average of the patient'"'"'s historic serum sodium concentrations, and estimating SNa⁺_estimated, the patient'"'"'s pre-dialysis serum sodium concentration, based on the average of the patient'"'"'s measured historic pre-dialysis serum sodium concentrations, SNa⁺_measured. The method enables adjusting DNa⁺, the sodium concentration of the dialysate solution, based on the average of the patient'"'"'s historic serum sodium concentrations, SNa⁺_average, if needed, and performing the dialysis treatment of the patient using a dialysate solution containing a sodium concentration DNa⁺.

Claims

1. A method of controlling diffusive sodium transport from dialysate solution to blood of a patient undergoing hemodialysis treatment or from blood into the dialysate solution comprising:

a) calculating SNa⁺_average, an average of the patient'"'"'s measured historic serum sodium concentrations, SNa⁺_measured;

b) estimating SNa⁺_estimated, the patient'"'"'s pre-dialysis serum sodium concentration, based on the average, SNa⁺_average, of the patient'"'"'s pre-dialysis serum sodium concentrations over a historic time interval of at least 4 months;

c) determining GNa+, a desired gradient between SNa⁺_estimated and DNa⁺, the sodium concentration in a dialysate solution; and

d) performing the dialysis treatment of the patient using the dialysate solution containing the sodium concentration DNa⁺ based upon SNa⁺_estimated.

2. The method of claim 1, wherein the patient'"'"'s historic serum sodium concentrations include corrections for void volume and Gibbs-Donnan effect.

3. The method of claim 1, wherein DNa⁺=SNa⁺_estimated.

4. The method of claim 2, wherein DNa⁺=SNa⁺_estimated.