Fluid sensing and control in a fluidic analyzer

• US 8,518,328 B2
• Filed: 12/27/2005
• Issued: 08/27/2013
• Est. Priority Date: 12/27/2005
• Status: Active Grant

• Current Assignee: Honeywell International Inc.
• Original Assignee: Honeywell International Inc.
• Inventors: Padmanabhan, Aravind, Rezachek, Tom, Bardell, Ron L.
• Primary Examiner(s): Jarrett, Lore
• Application Number:
  US11/306,402
• Publication Number:
  US 20070148039A1
• Time in Patent Office: 2,800 Days
• Field of Search: 422/67
• US Class Current: 422/67
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/143 Quality control, feedback systems
• CPC Class Codes: B01L 2200/147 Employing temperature sensors
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/0605 check valves
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: G01N 33/80 involving blood groups or blood types or red blood cells white blood cells G01N33/56972
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes

Abstract

Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.

Claims

1. A fluidic analyzer, comprising:

a flow channel for transporting a fluid;

one or more sensors, the one or more sensors positioned relative to the flow channel such that the one or more sensors sense one or more properties of the fluid being transported down the flow channel other than fluid velocity; and

a controller coupled to the one or more sensors, the controller determining if the fluid that is being transported down the flow channel is of a desired fluid type based on the one or more properties sensed by the one or more sensors, wherein the controller issues an error and halts operation of a fluidic analysis if the fluid that is being transported down the flow channel is not of the desired fluid type.

2. The fluidic analyzer of claim 1 wherein at least one of the one or more sensors is a thermal conductivity sensor.

3. The fluidic analyzer of claim 1 wherein at least one of the one or more sensors is a specific heat sensor.

4. The fluidic analyzer of claim 1 wherein at least one of the one or more sensors is an electrical resistivity sensor.

5. The fluidic analyzer of claim 1 wherein the one or more sensors include a thermal conductivity sensor and a specific heat sensor.

6. The fluidic analyzer of claim 5 further comprising at least one flow rate sensor.

7. The fluidic analyzer of claim 6 wherein the at least one flow rate sensor include a thermal anemometer type flow sensor.

8. The fluidic analyzer of claim 1 wherein the flow channel is part of a disposable fluidic cartridge, and the controller is part of an instrument, wherein the instrument removably receives the disposable fluidic cartridge.

9. The fluidic analyzer of claim 8 wherein at least one of the one or more sensors is part of the disposable fluidic cartridge.

10. The fluidic analyzer of claim 8 wherein at least one of the one or more sensors is part of the instrument that removably receives the disposable fluidic cartridge.

11. A fluidic analyzer, comprising:

a disposable fluidic cartridge having a flow channel for transporting a fluid;

an instrument that removably receives the disposable fluidic cartridge, the instrument including a controller; and

the disposable fluidic cartridge including one or more sensors positioned relative to the flow channel such that the one or more sensors sense one or more properties of the fluid being transported down the flow channel, wherein the one or more properties include at least one of thermal conductivity, specific heat and electrical resistivity the one or more sensors being in communication with the controller of the instrument, wherein the controller in conjunction with the one or more sensors, determines if the fluid being transported down the flow channel is of a desired fluid type based on the one or more properties sensed by the one or more sensors, and issues an error if the fluid that is being transported down the flow channel is not of the desired fluid type.

12. The fluidic analyzer of claim 11 wherein the controller halts operation of a fluidic analysis if the fluid that is being transported down the flow channel is not of the desired fluid type.

13. The fluidic analyzer of claim 11 wherein at least one of the one or more sensors is a thermal anemometer type sensor.

14. The fluidic analyzer of claim 11 further comprising at least one flow rate sensor.

15. A fluidic analyzer, comprising:

a disposable fluidic cartridge having a flow channel for transporting a fluid;

an instrument that receives the disposable fluidic cartridge, the instrument including a controller; and

the instrument including one or more sensors positioned relative to the flow channel such that the one or more sensors sense one or more properties of the fluid being transported down the flow channel, wherein each of the one or more sensors sense a fluid property other than fluid velocity, the one or more sensors in communication with the controller of the instrument, wherein the controller in conjunction with the one or more sensors determines if the fluid being transported down the flow channel is of a desired fluid type based on the one or more properties sensed by the one or more sensors, and issues an error if the fluid that is being transported down the flow channel is not of the desired fluid type.

16. The fluidic analyzer of claim 15 wherein the controller halts operation of a fluidic analysis if the fluid that is being transported down the flow channel is not of the desired fluid type.

17. The fluidic analyzer of claim 15 further comprising at least one flow rate sensor.