Cosmetic or dermatological preparation comprising a nutrient medium phase

• US 8,518,422 B2
• Filed: 03/01/2005
• Issued: 08/27/2013
• Est. Priority Date: 05/24/2003
• Status: Active Grant

• Current Assignee: La Prairie Group AG (maxingvest GmbH & Co. KGaA)
• Original Assignee: La Prairie Group AG (maxingvest GmbH & Co. KGaA)
• Inventors: Evangelisti, Carmen, Gohla, Sven, Mnks, Monika, Ibanez, Sybille
• Primary Examiner(s): Klinkel, Kortney L
• Application Number:
  US11/068,052
• Publication Number:
  US 20050287182A1
• Time in Patent Office: 3,101 Days
• Field of Search: 424/401
• US Class Current: 424/401
• CPC Class Codes: A61F 2013/00748 with hydrocolloids or superabsorbers
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A cosmetic or dermatological preparation that is obtainable by combining collagen and/or a derivative thereof, chitosan and/or a derivative thereof and glycosylaminoglycan and/or a derivative thereof with one or more selected substances. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Claims

1. A cosmetic or dermatological preparation, wherein the preparation is ready for application to skin, is in the form of at least one of a gel, an O/W emulsion, a W/O/W emulsion, a W/O emulsion, a microemulsion, an ointment, a cream, a dusting powder, a foam, an aerosol preparation, and a cosmetic stick, and is obtainable by combining substances comprising

(a) at least one of collagen and a derivative thereof;

(b) at least one of chitosan and an acetyl derivative thereof with a degree of acetylation of up to about 50%;

(c) at least one of a glycosylaminoglycan and a derivative thereof; and

(d) at least ten substances selected from amino acids, α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, folic acid, glucose, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, and ZnSO₄,

substances (a) to (c) being employed in a total amount of from about 0.0005% to about 50% by weight, based on a total weight of the preparation.

2. The preparation of claim 1, wherein the amino acids comprise one or more of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-cysteine, L-cystine, glycine, L-glutamine, L-glutamic acid, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, and the hydrochloride salts thereof.

3. The preparation of claim 1, wherein at least fifty substances from group (d) are employed.

4. The preparation of claim 1, wherein one or more of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine, and L-glycine are employed.

5. The preparation of claim 4, wherein at least three of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine, and glycine are employed.

6. The preparation of claim 5, wherein at least five of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine, and glycine are employed.

7. The preparation of claim 1, wherein glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine, and glycine are employed.

8. The preparation of claim 1, wherein at least one of substances (a) and (b) is of marine origin or of synthetic origin.

9. The preparation of claim 1, wherein the collagen comprises one or more collagens selected from types 1, 3, 4 and 5.

10. The preparation of claim 1, wherein the chitosan comprises chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol.

11. The preparation of claim 10, wherein the chitosan comprises chitosan obtained from at least one of crustaceans and insects.

12. The preparation of claim 1, wherein the glycosylaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

13. The preparation of claim 1, wherein substances (a) to (c) are employed in a total amount of from about 0.0015% to about 30% by weight.

14. The preparation of claim 1, wherein substances (a) to (c) are employed in a total amount of from about 0.005% to about 10% by weight.

15. The preparation of claim 1, wherein substances (a) to (c) are employed in a total amount of from about 0.01% to about 1% by weight, based on a total weight of the preparation.

16. The preparation of claim 1, wherein substances (a) to (c) are employed in a total amount of from about 0.015% to about 0.1% by weight.

17. The preparation of claim 1, wherein a weight ratio of substances (a) and (c) is from about 35:

1 to about 3;

1.

18. The preparation of claim 13, wherein a weight ratio of substances (a) and (c) is from about 20:

1 to about 6;

1.

19. The preparation of claim 14, wherein a weight ratio of substances (a) and (c) is from about 10:

1 to about 8;

1.

20. The preparation of claim 1, wherein a weight ratio of substances (a) and (b) is from about 10:

1 to about 1.5;

1.

21. The preparation of claim 13, wherein a weight ratio of substances (a) and (b) is from about 7:

1 to about 2.5;

1.

22. The preparation of claim 14, wherein a weight ratio of substances (a) and (b) is from about 5:

1 to about 3.5;

1.

23. The preparation of claim 1, wherein a weight ratio of substances (b) and (c) is from about 10:

1 to about 1;

1.

24. The preparation of claim 13, wherein a weight ratio of substances (b) and (c) is from about 5:

1 to about 1.5;

1.

25. The preparation of claim 14, wherein a weight ratio of substances (b) and (c) is from about 3:

1 to about 2;

1.

26. The preparation of claim 1, wherein the preparation comprises one or more skin cell culture media.

27. The preparation of claim 26, wherein the skin cell culture media comprise at least one of DMEM/HAM F12 (1:

1) and MCDB 153.

28. The preparation of claim 26, wherein the skin cell culture media are selected from one or more of physiological saline solution, nutrient media, and complete media for culturing primary body cells.

29. The preparation of claim 26, wherein the one or more skin cell culture media comprise culture media for at least one of primary fibroblasts and keratinocytes.

30. The preparation of claim 28, wherein the complete media are supplemented with serum substitutes.

31. The preparation of claim 1, wherein the preparation further comprises a citrate buffer.

32. The preparation of claim 1, wherein the preparation further comprises at least one of Q10, alpha-glucosyl rutin, an alpha-hydroxy acid, Zn orotate, carnitine, creatine, and taurine.

33. The preparation of claim 1, wherein the preparation comprises water.

34. The preparation of claim 33, wherein the preparation comprises at least about 30% by weight of water, based on a total weight of the preparation.

35. The preparation of claim 33, wherein the preparation comprises at least about 50% by weight of water, based on a total weight of the preparation.

36. The preparation of claim 26, wherein the preparation comprises at least about 50% by weight of water, based on a total weight of the preparation.

37. The preparation of claim 1, wherein the preparation is present as an aqueous gel.

38. The preparation of claim 1, wherein the preparation is present as an O/W emulsion.

39. The preparation of claim 1, wherein the preparation is present as a W/O emulsion.

40. The preparation of claim 1, wherein the preparation is present as a microemulsion.

41. The preparation of claim 1, wherein the preparation is present as a cosmetic stick.

42. The preparation of claim 1, wherein the preparation is present as an ointment.

43. The preparation of claim 1, wherein the preparation is present as a cream.

44. The preparation of claim 1, wherein the preparation is present as a dusting powder.

45. The preparation of claim 1, wherein the preparation is present as a foam.

46. The preparation of claim 1, wherein the preparation is present as an aerosol preparation.

47. A cosmetic or dermatological preparation, wherein the preparation is ready for application to skin, is in the form of at least one of a gel, an O/W emulsion, a W/O/W emulsion, a W/O emulsion, a microemulsion, an ointment, a cream, a dusting powder, a foam, an aerosol preparation, and a cosmetic stick, and is obtainable by combining substances comprising

(a) at least one of collagen and a derivative thereof, the collagen comprising one or more collagens selected from types 1, 3, 4 and 5;

(b) at least one of chitosan and an acetyl derivative thereof with a degree of acetylation of up to about 50%, the chitosan comprising chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol;

(c) at least one of a glycosylaminoglycan and a derivative thereof, the glycosylaminoglycan comprising at least one of chondroitin 4-sulfate and chondroitin 6-sulfate; and

(d) at least ten substances selected from amino acids, α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, folic acid, glucose, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, and ZnSO₄,

substances (a) to (c) being employed in a total amount of from about 0.005% to about 10% by weight, based on a total weight of the preparation.

48. The preparation of claim 47, wherein at least three of glucose, folic acid, L-lysine, L-threonine, L-arginine, L-serine, L-histidine, and glycine are employed.

49. The preparation of claim 47, wherein substances (a) to (c) are employed in a total amount of from about 0.01% to about 1% by weight, based on a total weight of the preparation.

50. The preparation of claim 47, wherein a weight ratio of substances (a) and (c) is from about 10:

1 to about 8;

1.

51. The preparation of claim 47, wherein a weight ratio of substances (a) and (b) is from about 7:

1 to about 2.5;

1.

52. The preparation of claim 49, wherein a weight ratio of substances (a) and (b) is from about 5:

1 to about 3.5;

1.

53. The preparation of claim 47, wherein a weight ratio of substances (b) and (c) is from about 10:

1 to about 1;

1.

54. The preparation of claim 49, wherein a weight ratio of substances (b) and (c) is from about 5:

1 to about 1.5;

1.

55. The preparation of claim 50, wherein a weight ratio of substances (b) and (c) is from about 3:

1 to about 2;

1.

56. The preparation of claim 47, wherein the preparation comprises one or more skin cell culture media.

57. The preparation of claim 56, wherein the skin cell culture media comprise at least one of DMEM/HAM F12 (1:

1) and MCDB 153.

58. The preparation of claim 56, wherein the one or more skin cell culture media comprise culture media for at least one of primary fibroblasts and keratinocytes.

59. The preparation of claim 47, wherein the preparation further comprises a citrate buffer.

60. The preparation of claim 47, wherein the preparation further comprises at least one of Q10, alpha-glucosyl rutin, an alpha-hydroxy acid, Zn orotate, carnitine, creatine and taurine.

61. The preparation of claim 47, wherein the preparation comprises at least about 30% by weight of water, based on a total weight of the preparation.

62. The preparation of claim 47, wherein the preparation comprises at least about 50% by weight of water, based on a total weight of the preparation.

63. The preparation of claim 47, wherein the preparation is present as an aqueous gel.

64. The preparation of claim 47, wherein the preparation is present as an O/W emulsion.

65. The preparation of claim 47, wherein the preparation is present as a W/O emulsion.

66. A cosmetic or dermatological preparation, wherein the preparation is ready for application to skin, is in the form of at least one of a gel, an O/W emulsion, a W/O/W emulsion, a W/O emulsion, a microemulsion, an ointment, a cream, a dusting powder, a foam, an aerosol preparation, and a cosmetic stick, and is obtainable by combining substances comprising

(a) at least one of collagen and a derivative thereof, the collagen comprising one or more collagens selected from types 1, 3, 4 and 5;

(b) at least one of chitosan and an acetyl derivative thereof with a degree of acetylation of up to about 50%, the chitosan comprising chitosan having a molecular weight of from about 80,000 g/mol to about 15,000,000 g/mol;

(c) at least one of a glycosylaminoglycan and a derivative thereof, the glycosylaminoglycan comprising at least one of chondroitin 4-sulfate and chondroitin 6-sulfate; and

(d) at least ten substances selected from amino acids, α

-biotin, (NH₄)₆Mo₇O₂₄, adenine, AlCl₃, biotin, CaCl₂, calcium pantothenate, choline chloride, CoCl₂, CrK(SO₄)₂, CuSO₄, D-Ca pantothenate, EDTA.Na₂, EDTA.Na₃, Fe(NO₃)₃, FeSO₄, folic acid, glucose, H₂SeO₃, HEPES, hypoxanthine, insulin human, KCl, linoleic acid, lipoic acid, MgCl₂, MnCl₂, MnSO₄, myo-inositol, Na₂HPO₄, Na₂SeO₃, Na₂SiO₃, NaCl, NaH₂PO₄, NaHCO₃, sodium pyruvate, sodium acetate, NH₄VO₃, NiCl₂, nicotinamide, phenol red, polysorbate 80, putrescine, putrescine 2HCl, pyridoxine HCl, pyridoxal HCl, riboflavin, SnCl₂, thiamine HCl, thymidine, vitamin B₁₂, and ZnSO₄,

substances (a) to (c) being employed in a total amount of from about 0.015% to about 1% by weight, based on a total weight of the preparation, a weight ratio of substances (a) and (c) being from about 10;

1 to about 8;

1, and a weight ratio of substances (a) and (b) being from about 7;

1 to about 2.5;

1.

67. The preparation of claim 66, wherein the preparation comprises one or more skin cell culture media.

68. The preparation of claim 66, wherein the preparation further comprises a citrate buffer.

69. The preparation of claim 66, wherein the preparation further comprises at least one of Q10, alpha-glucosyl rutin, an alpha-hydroxy acid, Zn orotate, carnitine, creatine, and taurine.

70. The preparation of claim 66, wherein the preparation comprises at least about 50% by weight of water, based on a total weight of the preparation.