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Stem cell capture and immobilization coatings for medical devices and implants

  • US 8,518,431 B2
  • Filed: 07/06/2012
  • Issued: 08/27/2013
  • Est. Priority Date: 08/07/2008
  • Status: Expired due to Fees
First Claim
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1. A method of constructing a target cell-carrying medical implant device, said method comprising the steps of:

  • a. providing a porous biocompatible medical implant comprising a solid exterior surface having a plurality of pores;

    b. providing a solution comprised of the following components;

    (i) a non-polar liquid, (ii) a polar liquid and (ii) a plurality of amphiphilic molecules composed of hydrophobic tail ends and hydrophilic head ends, wherein said head ends have a binding affinity for one or more target cells, further wherein said solution components assemble into non-polar-liquid-filled micelles or micelle-like constructs;

    c. contacting said micelles or micelle-like constructs with a solution containing target cells to which the hydrophilic head ends of said amphiphilic molecules have a binding affinity and inducing said micelles or micelle-like constructs to bind said target cells and form micelle-target cell units; and

    d. introducing said micelle-target cell units into the pores of said implant exterior surface so as to yield a medical implant device having target cells immobilized within said exterior surface pores.

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