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Thyroid hormone analogs and methods of use

  • US 8,518,451 B2
  • Filed: 11/25/2009
  • Issued: 08/27/2013
  • Est. Priority Date: 09/15/2003
  • Status: Active Grant
First Claim
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1. A method for inhibiting angiogenesis in a patient, said method comprising administering to a subject in need thereof an effective amount of tetraiodothyroacetic acid (TETRAC) conjugated via a covalent bond to a polymer, wherein said polymer is polyglycolide, polylactic acid, or co-polymers thereof, wherein said polymer is formulated into a nanoparticle, wherein the nanoparticle is less than 200 nanometers, and wherein the tetraiodothyroacetic acid (TETRAC) acts at the cell membrane level to inhibit pro-angiogenesis agents.

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