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Rapid detection of volatile organic compounds for identification of Mycobacterium tuberculosis in a sample

  • US 8,518,663 B2
  • Filed: 04/27/2010
  • Issued: 08/27/2013
  • Est. Priority Date: 04/27/2009
  • Status: Active Grant
First Claim
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1. A method for identifying Mycobacterium tuberculosis bacteria in a sample, the method comprising:

  • detecting one or more volatile organic compounds associated with Mycobacterium tuberculosis metabolism, wherein the volatile organic compounds are indicative of at least one of a presence of, response to treatment of, and resistance of the Mycobacterium tuberculosis bacteria in the sample, the one or more volatile organic compounds being selected from the group consisting of ethyl propionate, 1-pentanol, methyl valerate, 1-hexanol, ethyl valerate, methyl caproate, ethyl caproate, and any of the foregoing compounds in isotopically labeled form;

    determining the amount of the one or more volatile organic compounds; and

    identifying Mycobacterium tuberculosis in the sample based on presence and concentration of one or more volatile organic compounds.

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