Compositions comprising azelastine and methods of use thereof
DCFirst Claim
1. A method of treating a physical disorder in an animal suffering from or predisposed thereto, comprising administering to said animal an effective amount of a liquid pharmaceutical composition comprising;
- about 0.1% to about 0.15% (w/v) azelastine hydrochloride;
about 0.1% to about 0.15% (w/v) sucralose; and
about 0.1% to about 10% (w/v) sorbitol 70%wherein said physical disorder is selected from the group consisting of allergic rhinitis and non-allergic vasomotor rhinitis, andwherein said liquid pharmaceutical composition is formulated in the form of a nasal spray or nasal drops.
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Abstract
The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.
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Citations
20 Claims
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1. A method of treating a physical disorder in an animal suffering from or predisposed thereto, comprising administering to said animal an effective amount of a liquid pharmaceutical composition comprising;
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about 0.1% to about 0.15% (w/v) azelastine hydrochloride; about 0.1% to about 0.15% (w/v) sucralose; and about 0.1% to about 10% (w/v) sorbitol 70% wherein said physical disorder is selected from the group consisting of allergic rhinitis and non-allergic vasomotor rhinitis, and wherein said liquid pharmaceutical composition is formulated in the form of a nasal spray or nasal drops. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification