Small magnet and RF coil for magnetic resonance relaxometry

• US 8,519,708 B2
• Filed: 11/06/2008
• Issued: 08/27/2013
• Est. Priority Date: 11/06/2007
• Status: Active Grant

• Current Assignee: T2 Biosystems, Inc
• Original Assignee: T2 Biosystems, Inc
• Inventors: Prado, Pablo J., Lowery, Thomas J. Jr.
• Primary Examiner(s): Koval, Melissa
• Assistant Examiner(s): MILLER, DANIEL R
• Application Number:
  US12/741,789
• Publication Number:
  US 20100308822A1
• Time in Patent Office: 1,755 Days
• Field of Search: 324307-315, 324318-322
• US Class Current: 324/309
• CPC Class Codes: G01N 24/08 by using nuclear magnetic resonance G01N24/12 takes precedence
• CPC Class Codes: G01R 33/243 Spatial mapping of the polarizing magnetic field
• CPC Class Codes: G01R 33/302 Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
• CPC Class Codes: G01R 33/307 specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
• CPC Class Codes: G01R 33/34053 Solenoid coils; Toroidal coils
• CPC Class Codes: G01R 33/3806 Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
• CPC Class Codes: G01R 33/383 using permanent magnets
• CPC Class Codes: G01R 33/44 using nuclear magnetic resonance [NMR] G01R33/24, G01R33/62 take precedence
• CPC Class Codes: G01R 33/448 Relaxometry, i.e. quantification of relaxation times or spin density G01R33/50 takes precedence
• CPC Class Codes: G01R 33/465 applied to biological material, e.g. in vitro testing

Abstract

Small and inexpensive probeheads for use in nuclear magnetic resonance systems, in particular, magnetic resonance relaxometry systems are provided. The design of the magnet-radiofrequency coil configurations within the probeheads is guided by an excitation bandwidth associated with radiofrequency pulses to be applied to a sample.

Claims

1. A probehead for use in a portable magnetic resonance relaxometer, comprising:

(a) two permanent magnets connected by a steel c-shaped yoke, the south pole surface of one of the permanent magnets opposing the north pole surface of the other permanent magnet to form a gap and to provide the magnetic field in the gap at a strength of less than 1.1 Tesla;

(b) a space capable of accommodating a sample volume having an associated excitable volume; and

(c) a radiofrequency coil positioned partly or completely within the gap, said radiofrequency coil wound in a cylindrical shape to enclose a volume having a diameter of approximately 1 mm and a length of approximately 2 mm, the radiofrequency coil being positioned such that its detection volume overlaps at least partly with the excitable volume;

wherein the magnetic field provided is inhomogeneous and the space accommodating the sample volume and the radiofrequency coil are adapted and positioned according to a radiofrequency CPMG pulse bandwidth optimized for a magnetic field distribution corresponding to the position of the sample volume; and

wherein the probehead is optimized to obtain T2 relaxometry parameters from a sample contained in the detection volume.

2. The probehead of claim 1, a radiofrequency pulse being provided by the radiofrequency coil.

3. The probehead of claim 1, further comprising a housing, wherein the at least one magnet or magnetic field generator and the radiofrequency coil is attached to the housing.

4. The probehead of claim 1, wherein the detection volume includes between about 10 percent and about 100 percent of the excitable volume.

5. The probehead of claim 1, wherein (i) the radiofrequency coil is part of a radiofrequency circuit, the radiofrequency circuit comprising a capacitor and (ii) the radiofrequency coil is positioned to have the coil volume include between about 80 percent and about 100% of the excitable volume.

6. The probehead of claim 1, wherein the radiofrequency pulse length is between about 0.4 microseconds and about 10 microseconds.

7. The probehead of claim 1, further comprising at least one capacitor, the at least one capacitor and the radiofrequency coil being part of a radiofrequency circuit.

8. The probehead of claim 1, wherein each of the at least one magnet or magnetic field generator is in any dimension less than about two inches.

9. The probehead of claim 1, wherein said sample volume comprises a sensing agent capable of sensing a sample characteristic.

10. The probehead of claim 9, wherein said sensing agent comprises dry reagents compositions, magnetic particles, responsive polymers, or magnetic resonance contrast agents.

11. The probehead of claim 9, wherein said sample characteristic is hydration state.

12. The probehead of claim 9, wherein said sensing agent is a superparamagnetic nanoparticle.

13. The probehead of claim 12, wherein said superparamagnetic nanoparticles have binding moieties attached such that binding of said nanoparticles to an analyte results in an alteration of T2 signal.

14. A method of preparing a probehead for use in a portable magnetic resonance relaxometer, the method comprising the steps of:

(a) attaching two magnets or two magnetic field generators to a steel c-shaped yoke such that the south pole surface of one of the magnets or magnetic field generators opposes the north pole surface of the other magnet or magnetic field generator to form a gap between the magnets or magnetic field generators and to provide a magnetic field in the gap having a strength of less than about 1.1 Tesla;

(b) positioning a space capable of accommodating a sample volume having an associated excitable volume; and

(c) positioning a radiofrequency coil wound in a cylindrical shape to enclose a volume having a diameter of approximately 1 mm and a length of approximately 2 mm and being adapted to emit a radiofrequency pulse with a pulse length, the radiofrequency coil being positioned and designed to have the detection volume at least partly overlap with an excitable volume within the gap;

wherein the probehead is optimized to obtain T2 relaxometry parameters from a sample contained in the sample volume.