Method for searching and constructing 3D image database
First Claim
Patent Images
1. A method for database construction comprising the following steps:
- (a) providing more than one three-dimensional (3D) network motif images;
(b) aligning and correcting 3D images generated in (a) according to a 3D standardized coordinate, wherein each point registered to the 3D images is assigned a coordinate location (x, y, z) to indicate its position in the standardized space area;
(c) dividing 3D images in (b) with individual voxel or a self-defined brick consisting various voxels, wherein voxel is a volume element, representing 1×
1×
1 unit on a regular grid in the standardized space area;
(d) categorizing space information of each coordinate point registered to the 3D images within voxels;
(e) storing processed 3D network motif images in (c) and space information in (d) into a computer-readable recording medium; and
(f) providing skeletal forms of said 3D network motif images processed with path tracing algorithm.
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Abstract
The present invention relates to methods for searching and constructing a 3D motif image database, wherein said 3D motif image database can be used to understand the connection relationship of a 3D network, e.g. a neural network comprising biological neural networks or artificial neural networks. The searching and constructing methods are applied on the 3D motif image database, a proper computer-aided graphic platform. The database not only facilitates the management of the huge amount of categorized data but also rationally excavates the hidden information cloaked within.
20 Citations
22 Claims
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1. A method for database construction comprising the following steps:
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(a) providing more than one three-dimensional (3D) network motif images; (b) aligning and correcting 3D images generated in (a) according to a 3D standardized coordinate, wherein each point registered to the 3D images is assigned a coordinate location (x, y, z) to indicate its position in the standardized space area; (c) dividing 3D images in (b) with individual voxel or a self-defined brick consisting various voxels, wherein voxel is a volume element, representing 1×
1×
1 unit on a regular grid in the standardized space area;(d) categorizing space information of each coordinate point registered to the 3D images within voxels; (e) storing processed 3D network motif images in (c) and space information in (d) into a computer-readable recording medium; and (f) providing skeletal forms of said 3D network motif images processed with path tracing algorithm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for interactive query of a 3D network database comprising the following steps:
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(a) providing a 3D network motif image database, wherein the 3D network motif image database is used to understand the connection relationship of the 3D network, and constructing an interactive query interface for users; (b) selecting at least one spatial region, wherein said spatial region comprises at least one 3D rectangular space, at least one branch path or a Boolean combination of the aforementioned objects, or entering at least one search string in query interface in (a) to search for corresponding images information meeting the query criteria, wherein said corresponding images information meeting the query criteria in database refers to a name of neuron, the characteristics of the neuronal image, and the 3D neuronal image in database as described in (a); (c) presenting said resulting images meeting the query criteria in (b) with dot-matrix or image forms with texts on the query interface, wherein a search string comprises the texts of at least one name of the motif image or at least one source of the network motif image or the Boolean operation of above; and (d) providing the dot-matrix represents the number of terminals of the neuron path tracing graph in each unit space. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification