Cardiac response classification using multisite sensing and pacing

• US 8,521,284 B2
• Filed: 12/12/2003
• Issued: 08/27/2013
• Est. Priority Date: 12/12/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kim, Jaeho, Bocek, Joseph, Meyer, Scott A., Haefner, Paul A., Sih, Haris J.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US10/735,519
• Publication Number:
  US 20050131478A1
• Time in Patent Office: 3,546 Days
• Field of Search: 607/9, 607 26- 28, 600/510
• US Class Current: 607/27
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Methods and devices for classifying a cardiac pacing response involve using a first electrode combination for pacing and a second electrode combination for sensing a cardiac signal following pacing. The cardiac response to pacing may be classified using the sensed cardiac signal. One process involves using the sensed cardiac signal to detect the cardiac response as a fusion/pseudofusion beat. Another process involves using the sensed cardiac signal to classify the cardiac response to pacing as one of at least three cardiac response types.

Claims

1. A method of determining a cardiac response to a pacing pulse, comprising:

providing a plurality of electrodes electrically coupled to a heart;

delivering the pacing pulse to the heart using a first electrode combination;

sensing a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

classifying the cardiac response to the pacing pulse as one of a captured response, a non-captured response, and a fusion/pseudofusion response by distinguishing between each of the captured, non-captured, and fusion/pseudofusion responses using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.

2. The method of claim 1, further comprising:

detecting noise on the cardiac signal; and

canceling the classification of the cardiac response based on the detection of noise.

3. The method of claim 1, wherein:

sensing the cardiac signal comprises detecting a characteristic of the cardiac signal; and

classifying the cardiac response comprises;

comparing the detected characteristic to a reference; and

classifying the cardiac response based on the comparison.

4. The method of claim 3, wherein:

detecting the characteristic of the cardiac signal comprises detecting an amplitude of the cardiac signal; and

comparing the detected characteristic to a reference comprises comparing the detected amplitude to an amplitude reference.

5. The method of claim 3, wherein:

detecting the characteristic comprises detecting a slope of the cardiac signal; and

comparing the detected characteristic to a reference comprises comparing the detected slope to a slope reference.

6. The method of claim 3, wherein:

detecting the characteristic of the cardiac signal comprises detecting a curvature of the cardiac signal; and

comparing the detected characteristic to a reference comprises comparing the detected curvature to a curvature reference.

7. The method of claim 3, wherein:

detecting the characteristic of the cardiac signal comprises detecting a peak width of the cardiac signal; and

comparing the detected characteristic to a reference comprises comparing the detected peak width to a peak width reference.

8. The method of claim 3, wherein:

detecting the characteristic of the cardiac signal comprises detecting one or more feature points of the cardiac signal; and

comparing the detected characteristic to a reference comprises;

providing a template; and

comparing the detected feature points to the template.

9. The method of claim 1, wherein:

delivering the pacing pulse to the heart using a first electrode combination comprises delivering the pacing pulse to using a near-field vector; and

sensing the cardiac signal following the pacing pulse using a second electrode combination comprises sensing the cardiac signal using a far-field vector.

10. The method of claim 1, wherein:

delivering the pacing pulse to the heart using a first electrode combination comprises delivering the pacing pulse using a rate channel vector; and

sensing the cardiac signal following the pacing pulse using a second electrode combination comprises sensing the cardiac signal using a shock channel vector.

11. The method of claim 1, wherein:

delivering the pacing pulse to the heart comprises delivering the pacing pulse to a ventricle using the first electrode combination; and

sensing the cardiac signal comprises sensing the cardiac signal using the second electrode combination.

12. The method of claim 1, wherein:

delivering the pacing pulse to the heart comprises delivering the pacing pulse to one ventricle using the first electrode combination; and

sensing the cardiac signal following the pacing pulse comprises sensing the cardiac signal using at least one electrode disposed in the other ventricle.

13. The method of claim 1, wherein:

delivering the pacing pulse to the heart comprises delivering the pacing pulse to an atrium using the first electrode combination; and

sensing the cardiac signal following the pacing pulse comprises sensing a cardiac signal using the second electrode combination.

14. The method of claim 1, wherein:

delivering the pacing pulse to the heart comprises delivering the pacing pulse to one atrium using the first electrode combination; and

sensing the cardiac signal following the pacing pulse comprises sensing a cardiac signal using at least one electrode disposed in the other atrium.

15. A method of determining a cardiac response to a pacing pulse, comprising:

providing a plurality of electrodes electrically coupled to a heart;

delivering the pacing pulse to the heart using a first electrode combination;

sensing a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

classifying the cardiac response to the pacing pulse as one of at least three cardiac response types by distinguishing between each of the at least three cardiac response types using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.

16. The method of claim 15, further comprising:

detecting noise on the cardiac signal; and

canceling the classification of the cardiac response based on the detection of noise.

17. The method of claim 15, wherein classifying the cardiac response as one of at least three cardiac response types comprises classifying the cardiac response type as a captured response.

18. The method of claim 15, wherein classifying the cardiac response as one of at least three cardiac response types comprises classifying the cardiac response type as a non-captured response.

19. The method of claim 15, wherein classifying the cardiac response as one of at least three cardiac response types comprises classifying the cardiac response type as a fusion/pseudofusion beat.

20. The method of claim 15, wherein classifying the cardiac response as one of at least three cardiac response types comprises classifying the cardiac response type as a near non-captured response.

21. The method of claim 15, wherein classifying the cardiac response as one of at least three cardiac response types comprises classifying the cardiac response type as a non-captured response added to an intrinsic beat.

22. The method of claim 15, wherein:

sensing the cardiac signal comprises detecting a characteristic of the cardiac signal; and

classifying the cardiac response comprises;

comparing the detected characteristic to a reference; and

classifying the cardiac response based on the comparison.

23. The method of claim 15, wherein:

delivering the pacing pulse to the heart using a first electrode combination comprises delivering the pacing pulse to a combination of electrodes associated with a near-field vector; and

sensing the cardiac signal following the pacing pulse using a second electrode combination comprises sensing the cardiac signal using a far-field vector.

24. A method of detecting a fusion/pseudofusion beat, comprising:

providing a plurality of electrodes electrically coupled to a heart;

delivering a pacing pulse to the heart using a first electrode combination;

sensing a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

detecting the fusion/pseudofusion beat using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.

25. The method of claim 24, wherein:

sensing the cardiac signal comprises detecting a characteristic of the cardiac signal; and

detecting the fusion/pseudofusion beat comprises;

comparing the detected characteristic to a reference; and

detecting the fusion/pseudofusion beat based on the comparison.

26. The method of claim 24, wherein:

delivering the pacing pulse to the heart using a first electrode combination comprises delivering the pacing pulse to using a near-field vector; and

sensing the cardiac signal following the pacing pulse using a second electrode combination comprises sensing the cardiac signal using a far-field vector.

27. The method of claim 24, wherein detecting the fusion/pseudofusion beat comprises:

defining a plurality of classification windows relative to and subsequent to the pacing pulse;

detecting a characteristic of the cardiac signal within a particular classification window; and

detecting the fusion/pseudofusion beat based on the detected characteristic and the particular classification window.

28. A medical device, comprising:

a plurality of electrodes electrically coupled to a heart;

a pulse delivery circuit configured to deliver a pacing pulse to a heart using a first electrode combination;

a sensing circuit configured to sense a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

a control circuit, the control circuit coupled to the sensing circuit and configured to classify a cardiac response to the pacing pulse as one of at least three cardiac response types by distinguishing between each of the at least three cardiac response types using the sensed cardiac signal without using any other cardiac signal sensed following the pacing pulse.

29. The device of claim 28, wherein the control circuit is further configured to detect the cardiac signal as a noisy signal and to cancel classification of the cardiac response based on the detection of noise.

30. The device of claim 28, wherein the control system is configured to define a plurality of classification windows relative to and subsequent to the pacing pulse, detect a characteristic of the cardiac signal within a particular classification window, and classify the cardiac response based on the detected characteristic and the particular classification window.

31. The device of claim 28, wherein:

the pulse delivery circuit is configured to deliver the pacing pulse using a near field electrode combination; and

the sensing circuit is configured to sense the cardiac signal using a far field electrode combination.

32. The device of claim 28, wherein:

the pulse delivery circuit is configured to deliver the pacing pulse using a rate channel electrode combination; and

the sensing circuit is configured to sense the cardiac signal using a shock channel electrode combination.

33. The device of claim 28, wherein:

the a plurality of electrodes includes a right ventricular pacing electrode, a right ventricular coil electrode, and a can electrode;

the pulse delivery circuit is configured to deliver the pacing pulse to the right ventricle using the right ventricular pacing electrode; and

the sensing circuit is configured to sense the cardiac signal using the right ventricular coil electrode and the can electrode.

34. The device of claim 28, wherein:

the plurality of electrodes includes a right chamber pacing electrode and a left chamber sensing electrode;

the pulse delivery circuit is configured to deliver the pacing pulse to a right chamber using the right chamber pacing electrode; and

the sensing circuit is configured to sense the cardiac signal of the right chamber using the left chamber sensing electrode.

35. The device of claim 28, wherein:

the plurality of electrodes includes a left chamber pacing electrode and a right chamber sensing electrode;

the pulse delivery circuit is configured to deliver the pacing pulse to a left chamber using the left chamber pacing electrode; and

the sensing circuit is configured to sense the cardiac signal of the left chamber using the right chamber sensing electrode.

36. The device of claim 28, wherein:

the plurality of electrodes includes a left ventricular pacing electrode and first and second right ventricular electrodes;

the pulse delivery circuit is configured to deliver the pacing pulse to a left ventricle using the left ventricular pacing electrode; and

the sensing circuit is configured to sense the cardiac signal of the left ventricle using the first and second right ventricular electrodes.

37. The device of claim 28, wherein:

the plurality of electrodes includes first and second right atrial electrodes;

the pulse delivery circuit is configured to deliver the pacing pulse to the right atrium using the first right atrial electrode; and

the sensing circuit is configured to sense the cardiac signal using the second right atrial electrode.

38. The device of claim 28, wherein the pulse delivery circuit further comprises a coupling capacitor through which the pacing pulse is delivered.

39. The device of claim 38, wherein the coupling capacitor has a value in a range of about 2 microfarads to about 22 microfarads.

50. The device of claim 28, wherein:

the a plurality of electrodes includes a right ventricular pacing electrode, a right ventricular coil electrode, a superior vena cava electrode, and a can electrode;

the pulse delivery circuit is configured to deliver the pacing pulse to the right ventricle using the right ventricular pacing electrode; and

the sensing circuit is configured to sense the cardiac signal using the right ventricular coil electrode and the superior vena cava electrode tied to the can electrode.

40. A medical device, comprising:

a plurality of electrodes electrically coupled to a heart;

a pulse delivery circuit configured to deliver a pacing pulse to a heart using a first electrode combination;

a sensing circuit configured to sense a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

a control circuit, the control circuit coupled to the sensing circuit and configured to detect a fusion/pseudofusion beat using the sensed cardiac signal without using any other cardiac signal sensed following the pacing pulse.

41. The device of claim 40, wherein the control circuit is further configured to detect the cardiac signal as a noisy signal and to cancel detection of the fusion/pseudofusion beat based on the detection of noise.

42. The device of claim 40, wherein:

the pulse delivery circuit is configured to deliver the pacing pulse using a rate channel vector; and

the sensing circuit is configured to sense the cardiac signal following the pacing pulse using a shock channel vector.

43. The device of claim 40, wherein:

the pulse delivery circuit is configured to deliver the pacing pulse using an electrode combination associated with a near-field vector; and

the sensing circuit is configured to sense the cardiac signal following the pacing pulse using a far-field vector.

44. The device of claim 40, wherein the control system is configured to define a plurality of classification windows relative to and subsequent to the pacing pulse, detect a characteristic of the cardiac signal within a particular classification window, and detect the fusion/pseudofusion beat based on the detected characteristic and the particular classification window.

45. A medical device for classifying a cardiac response, comprising:

means for providing a plurality of electrodes electrically coupled to a heart;

means for delivering the pacing pulse to the heart using a first electrode combination;

means for sensing a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

means for classifying the cardiac response to the pacing pulse as one of a captured response, a non-captured response, and a fusion/pseudofusion response by distinguishing between each of the captured, non-captured, and fusion/pseudofusion responses using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.

46. The device of claim 45, further comprising:

means for detecting noise on the cardiac signal; and

means for canceling the classification of the cardiac response based on the detection of noise.

47. A medical device for determining a cardiac response to a pacing pulse, comprising:

means for providing a plurality of electrodes electrically coupled to a heart;

means for delivering the pacing pulse to the heart using a first electrode combination;

means for sensing a single cardiac signal for cardiac response classification following the pacing pulse using a second electrode combination; and

means for classifying the cardiac response as one of at least three cardiac response types by distinguishing between each of the at least three cardiac response types using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.

48. The device of claim 47, further comprising:

means for detecting noise; and

means for canceling the classification of the cardiac response based on the detection of noise.

49. A system for detecting a fusion/pseudofusion beat, comprising:

means for providing a plurality of electrodes electrically coupled to a heart;

means for delivering a pacing pulse to the heart using a first electrode combination;

means for sensing a single cardiac signal for cardiac pacing response classification following the pacing pulse using a second electrode combination; and

means for detecting the fusion/pseudofusion beat using the single cardiac signal without using any other cardiac signal sensed following the pacing pulse.