Nasal devices

• US 8,522,778 B2
• Filed: 04/09/2010
• Issued: 09/03/2013
• Est. Priority Date: 02/26/2001
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Primary Examiner(s): MATTER, KRISTEN CLARETTE
• Application Number:
  US12/757,626
• Publication Number:
  US 20110088691A1
• Time in Patent Office: 1,243 Days
• Field of Search: 128/200.14, 128/200.23, 128/203.12, 128/203.15, 128/203.18, 128/203.22, 128/207.18, 128/204.12, 128/206.11
• US Class Current: 128/203.18
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/006 operated by applying mechanical pressure to the liquid to be sprayed or atomised
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/071 hand operated
• CPC Class Codes: A61M 2205/073 : Syringe, piston type
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2210/0668 : Middle ear
• CPC Class Codes: A61M 2230/43 : Composition of exhalation

Abstract

A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device including: a nosepiece for fitting to a nostril of a subject; a substance supply unit for supplying a substance for delivery through the nosepiece; and a delivery prevention mechanism for preventing delivery of a substance through the nosepiece until the nosepiece is properly fitted to the nostril of the subject.

Claims

1. A nasal delivery device for delivering a substance to a nasal cavity of a subject, including:

a nosepiece for insertion into a nostril of a subject;

a mouthpiece through which the subject in use exhales;

a flow path fluidly which connects the nosepiece and the mouthpiece, whereby exhaled air from an exhalation breath is deliverable through the flow path;

a substance supply unit operable to supply a substance for delivery through the nosepiece; and

a delivery prevention mechanism configured to prevent exhalation through the flow path, wherein the delivery prevention mechanism comprises first and second members movable relative to one another between first and second configurations, one of the members defining at least a part of the flow path, and the other member including a blocking element which blocks the flow path when the first and second members are in the first configuration and opens the flow path when the first and second members are in the second configuration.

2. The delivery device of claim 1, further including:

a biasing element for normally biasing the first and second members to the first configuration, whereby a predeterminable biasing force provided by the biasing element has to be overcome in moving the first and second members to the second configuration.

3. The delivery device of claim 1, wherein the substance supply unit includes a dosing unit for supplying at least one substance.

4. The delivery device of claim 3, wherein the dosing unit comprises a nebulizer for supplying an aerosol.

5. The delivery device of claim 3, wherein the dosing unit comprises an aerosol canister for supplying an aerosol.

6. The delivery device of claim 3, wherein the dosing unit comprises a delivery pump unit for supplying an aerosol, a liquid pump unit for supplying a liquid aerosol or a powder pump unit for supplying a powder aerosol.

7. The delivery device of claim 3, wherein the dosing unit comprises a powder delivery unit for delivering a powder aerosol.