Electronic device and system for detecting rejection in transplant recipients
First Claim
1. A method for detecting cardiac allograft rejection in a subject that has received a cardiac allograft, comprising:
- determining baseline data regarding the subject and the cardiac allograft;
measuring parameters of the cardiac allograft during a measurement interval;
determining average parameter values for the parameters during the measurement interval; and
comparing the average parameter values with the baseline data to detect the presence of a cardiac allograft rejection;
wherein the parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature.
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Accused Products
Abstract
The current invention relates to an implantable device, system, method, and computer readable medium comprising computer executable components for detection of rejection of a cardiac allograft. Acute rejection and chronic rejection are the leading cause of death in heart transplant recipients post transplant. The current invention seeks to address this problem by providing methods, devices, systems and computer readable media comprising computer executable components to monitor the efficacy of immunosuppressant therapy and evaluate the degree of rejection in a cardiac allograft. To provide this functionality, an implantable device comprises sensors which measure physiologic parameters at specified intervals after the transplant procedure. These measured parameters are subsequently compared with baseline parameter data to detect rejection of the cardiac allograft.
5 Citations
39 Claims
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1. A method for detecting cardiac allograft rejection in a subject that has received a cardiac allograft, comprising:
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determining baseline data regarding the subject and the cardiac allograft; measuring parameters of the cardiac allograft during a measurement interval; determining average parameter values for the parameters during the measurement interval; and comparing the average parameter values with the baseline data to detect the presence of a cardiac allograft rejection; wherein the parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An implantable device for detecting cardiac allograft rejection in a subject that has received a cardiac allograft, comprising:
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a plurality of sensors to measure parameters; a processor in electronic communication with the plurality of sensors, the processor configured to receive the measured parameters; a memory component to store baseline data, data corresponding the measured parameters and/or data corresponding average parameter values; a power supply component to provide electricity to components of the implantable device; and a housing to encapsulate components of the implantable device, wherein the parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. An external device adapted to communicate with an implantable device for detecting cardiac allograft rejection, the implantable device comprising:
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a plurality of sensors to measure parameters; a processor in electronic communication with the sensors, the processor configured to receive the measured parameters; and a memory component to store baseline data, data corresponding measured parameters and/or data corresponding to average parameter value, wherein the parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature. - View Dependent Claims (20, 21, 22)
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23. A system for detecting cardiac allograft rejection in a subject that received a cardiac allograft, comprising:
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an implantable device for detecting cardiac allograft rejection, comprising; a plurality of sensors to measure parameters, a processor in electronic communication with the plurality of sensors, the processor configured to receive the measured parameters, a memory component to store baseline data, data corresponding the measured parameters and/or data corresponding to average parameter values, a power supply component to provide electricity to components of the implantable device, and a housing to encapsulate components of the implantable device, wherein parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature; andan external device adapted to communicate with the implantable device. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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32. A non-transitory computer readable medium to detect cardiac allograft rejection in a subject that has received a cardiac allograft, comprising computer executable components for:
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determining baseline data regarding the subject and the cardiac allograft; measuring parameters of the cardiac allograft during a measurement interval; determining average parameter values for the parameters during the measurement interval; and comparing the average parameter values with the baseline data to detect the presence of a cardiac allograft rejection, wherein the parameters comprise;
impedance within the chest measured without implanting leads into the tissue of the cardiac allograft, electrical activity generated by the cardiac allograft, at least one voltage generated by the cardiac allograft, rate of change of the at least one voltage generated by the cardiac allograft, and body temperature. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39)
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Specification