Minimally invasive determination of collateral ventilation in lungs

• US 8,523,782 B2
• Filed: 10/27/2010
• Issued: 09/03/2013
• Est. Priority Date: 12/07/2005
• Status: Active Grant

• Current Assignee: Pulmonx Corp.
• Original Assignee: Pulmonx Corp.
• Inventors: Freitag, Lutz, Aljuri, Nikolai
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US12/913,637
• Publication Number:
  US 20110270116A1
• Time in Patent Office: 1,042 Days
• Field of Search: 600529-543, 600/484
• US Class Current: 600/538
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

Minimally invasive methods, systems and devices are provided for assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding airway of the target compartment. The feeding airway is occluded by the catheter and the opening and closing of a one-way valve coupled with the catheter is observed. If the valve ceases opening and closing over time, this may indicate that significant collateral ventilation into the target compartment is absent. If the valve continues to open and close over time, significant collateral ventilation into the compartment may be present. Based on the collateral ventilation assessment, a treatment plan may be generated.

Claims

1. A system for detecting collateral ventilation into a lung compartment in a patient, the system comprising:

a catheter having a lumen and adapted to be introduced transtracheally to a bronchus leading to a target lung compartment;

an occlusion member on a distal region of the catheter, said occlusion member being adapted to selectively occlude the bronchus;

a one-way valve coupled with a proximal region of the catheter and in fluid communication with the lumen;

a video camera adapted to capture video images of the one-way valve; and

wherein the occlusion member is configured to be deployed in the bronchus to prevent air from being inhaled into the target lung compartment through the bronchus, wherein the catheter is configured to allow air exhaled from the target lung compartment to pass through the lumen and the one-way valve, and wherein the catheter has sufficient overall length so that the one-way valve is located outside the patient during use.

2. A system as in claim 1, wherein the video camera comprises a USB camera.

3. A system as in claim 1, wherein the video camera is coupled with the proximal region of the catheter.

4. A system as in claim 3, wherein the video camera is coupled with a housing member, wherein the one-way valve is coupled with the housing member, and wherein the proximal region of the catheter is coupled with the housing member.

5. A system as in claim 1, further comprising a video monitor for displaying the video images captured by the video camera.

6. A system as in claim 1, wherein the one-way valve is removably coupled with the catheter.

7. A system as in claim 6, wherein the one-way valve comprises an endobronchial valve device.

8. A system as in claim 1, wherein the one-way valve is housed inside a housing member that is removably coupled with the proximal region of the catheter.

9. A system for detecting collateral ventilation into a lung compartment in a patient, the system comprising:

a catheter having a lumen and adapted to be introduced transtracheally to a bronchus leading to a target lung compartment;

an occlusion member on a distal region of the catheter, said occlusion member being adapted to selectively occlude the bronchus;

a one-way valve coupled with a proximal region of the catheter and in fluid communication with the lumen;

a filter coupled with the catheter to filter exhaled air traveling through the catheter to the valve wherein at least a portion of the catheter distal to the filter is removable from the system; and

wherein the occlusion member is configured to be deployed in the bronchus to prevent air from being inhaled into the target lung compartment through the bronchus, wherein the catheter is configured to allow air exhaled from the target lung compartment to pass through the lumen and the one-way valve, and wherein the catheter has sufficient overall length so that the one-way valve is located outside the patient during use.