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Methods and compositions for gene inactivation

  • US 8,524,221 B2
  • Filed: 05/05/2011
  • Issued: 09/03/2013
  • Est. Priority Date: 05/25/2006
  • Status: Active Grant
First Claim
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1. A method for inactivating a CCR-5 gene in an isolated CD34+ cell, the method comprising administering to the cell a polynucleotide encoding a first fusion protein comprising a first cleavage domain and a first engineered zinc finger protein DNA-binding domain, wherein the DNA-binding domain comprises four zinc finger recognition regions ordered F1 to F4 from N-terminus to C-terminus, and wherein F1, F3, and F4 comprise the following amino acid sequences:

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