Cadaveric allogenic human juvenile cartilage implant

• US 8,524,268 B2
• Filed: 12/15/2011
• Issued: 09/03/2013
• Est. Priority Date: 12/11/2003
• Status: Expired due to Fees

• Current Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Zimmer Incorporated (Zimmer Biomet Holdings, Inc.)
• Inventors: Kizer, Neil, Spiro, Robert, Yao, Jian, Blanchard, Cheryl Renee
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US13/327,238
• Publication Number:
  US 20120239146A1
• Time in Patent Office: 628 Days
• Field of Search: None
• US Class Current: 424/426
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/30764 Cartilage harvest sites
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 2310/00377 Fibrin
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3612 Cartilage, synovial fluid
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3817 Cartilage-forming cells, e.g. pre-chondrocytes
• CPC Class Codes: A61L 27/3852 Cartilage, e.g. meniscus
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C12N 2533/56 Fibrin; Thrombin
• CPC Class Codes: C12N 2533/80 Hyaluronan
• CPC Class Codes: C12N 5/0655 : Chondrocytes; Cartilage

Abstract

The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.

Claims

1. A cartilage implant, comprising:

cadaveric allogenic human juvenile cartilage tissue particles including viable chondrocytes;

a first matrix comprising a biocompatible adhesive or sealant; and

a second matrix comprising collagen, polylactic acid or polyglycolic acid.

2. The implant of claim 1, wherein the first matrix is selected from the group consisting of plasma-based adhesives or sealants, and protein-based adhesives or sealants, natural adhesives or sealants and any combination thereof.

3. The implant of claim 2, wherein the first matrix is a plasma-based adhesive.

4. The implant of claim 3, wherein the plasma-based adhesive comprises fibrin.

5. The implant of claim 1, wherein the second matrix comprises collagen.

6. The implant of claim 5, wherein the collagen is in the form of a fleece.

7. The implant of claim 1, wherein the second matrix comprises polyglycolic acid.

8. The implant of claim 1, wherein the cartilage particles are articular cartilage.

9. The implant of claim 1, wherein the cartilage particles have a dimension from about one to about three millimeters.

10. The implant of claim 1, wherein the cartilage particles range in size from about 1 to about 27 mm³.

11. The implant of claim 1, wherein the cartilage particles are from donors less than fifteen years of age.

12. The implant of claim 11, wherein the cartilage particles are from donors less than two years of age.

13. The implant of claim 11, wherein the cartilage particles are from donors from about 20 weeks to about 13 years of age.

14. The implant of claim 1, further comprising a retainer.

15. The implant of claim 14, wherein the retainer comprises a physical attachment device.

16. The implant of claim 15, wherein the physical attachment device is a tack or staple.

17. The implant of claim 8, wherein the cartilage particles are from a femoral condyle, a tibial plateau or a patella.

18. The implant of claim 17, wherein the cartilage particles are from a femoral condyle.