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Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds

  • US 8,524,676 B2
  • Filed: 09/08/2006
  • Issued: 09/03/2013
  • Est. Priority Date: 09/08/2005
  • Status: Expired due to Fees
First Claim
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1. A method of treating viral infection of mammalian cells by an Enterovirus or Rhinovirus, comprising exposing host cells to an effective amount of an antiviral compound that comprises a morpholino antisense oligonucleotide of between 15 and 25 morpholino subunits having a substantially uncharged, nuclease-resistant backbone containing phosphorodiamidate intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′

  • exocyclic carbon of an adjacent subunit, wherein the morpholino antisense oligonucleotide comprises a targeting sequence of at least 15 nucleotide bases complementary to SEQ ID NO;

    7 and, conjugated to the morpholino antisense oligonucleotide, an arginine-rich polypeptide effective to promote uptake of the antiviral compound into the host cells, wherein the arginine-rich polypeptide has the sequence of SEQ ID NO;

    15.

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