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Antisense oligonucleotides for inducing exon skipping and methods of use thereof

  • US 8,524,880 B2
  • Filed: 07/15/2010
  • Issued: 09/03/2013
  • Est. Priority Date: 06/28/2004
  • Status: Expired
First Claim
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1. An isolated antisense oligonucleotide of 20 to 50 nucleotides in length comprising at least 17 consecutive nucleotides of SEQ ID NO:

  • 207, wherein the oligonucleotide specifically hybridizes to an exon 45 acceptor splice site of a human dystrophin gene, inducing exon 45 skipping, and wherein the uracil bases are optionally thymine bases.

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