Device and method for determining analyte levels
First Claim
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1. A device for measuring a glucose concentration in a host, the device comprising:
- a sensor operably connected to an electronic circuit and configured to continuously measure a signal associated with a glucose concentration in a host; and
a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the membrane comprises a silicone-containing polymer;
wherein the device is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output over a range of pO2 from about 150 mm Hg down to about 30 mm Hg.
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Abstract
Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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Citations
66 Claims
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1. A device for measuring a glucose concentration in a host, the device comprising:
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a sensor operably connected to an electronic circuit and configured to continuously measure a signal associated with a glucose concentration in a host; and a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the membrane comprises a silicone-containing polymer; wherein the device is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than a 10% drop in sensor output over a range of pO2 from about 150 mm Hg down to about 30 mm Hg. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A device for measuring a glucose concentration in a host, the device comprising:
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a sensor operably connected to an electronic circuit and configured to continuously measure a signal associated with a glucose concentration in a host; and a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and glucose; wherein at least 95% of glucose concentration values measured by the device are within 25% of corresponding values determined by analysis of blood over a time period of at least two days. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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53. A device for measuring a glucose concentration in a host, the device comprising:
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an electrode surface operably connected to an electronic circuit and configured to continuously measure in vivo a signal associated with a glucose concentration in a host; and a membrane located over at least a portion of the electrode surface, wherein the membrane is configured to control a flux of oxygen and glucose; wherein at least 95% of glucose concentration values measured by the device are within 25% of corresponding values determined by analysis of blood over a time period of at least 2 days. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
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Specification