Method for discriminating anodal and cathodal capture

• US 8,527,050 B2
• Filed: 07/28/2011
• Issued: 09/03/2013
• Est. Priority Date: 07/28/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Stadler, Robert W., Sheldon, Todd J., Splett, Vincent E., Demmer, Wade M.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/192,697
• Publication Number:
  US 20130030491A1
• Time in Patent Office: 768 Days
• Field of Search: 607/9, 607/17, 607 25- 28, 600508-510
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.

Claims

1. A method for discriminating between cathodal and anodal cardiac capture during bipolar electrical stimulation, the method comprising:

delivering a first pacing pulse using a first candidate cathode electrode positioned along a heart chamber and a universal anode;

measuring a first control response to the first pacing pulse;

delivering a plurality of second pacing pulses using a plurality of candidate bipoles comprising the first candidate cathode electrode paired with each of a plurality of anodes positioned along the heart chamber;

measuring a bipolar response to the plurality of second pacing pulses for each of the plurality of candidate bipoles;

establishing a threshold response and a threshold range;

comparing the first control response to the threshold response;

responsive to the first control response meeting the threshold response, classifying the first control response as normal and comparing each of the bipolar responses to the first control response; and

classifying each of the bipolar responses for the plurality of candidate bipoles, wherein a given bipolar response for an associated candidate bipole of the plurality of bipoles is classified as normal if the given bipolar response is within the threshold range of the first control response and classified as abnormal if the bipolar response is outside the threshold range of the first control response.

2. The method of claim 1, further comprising detecting cathodal capture at the candidate cathode in response to all of the bipolar responses being classified as normal.

3. The method of claim 1, further comprising:

responsive to classifying a bipolar response as abnormal for an associated candidate bipole, computing a mean response for the candidate cathode using the normal first control response and all bipolar responses classified as normal;

determining if the abnormal conduction time approximately matches the mean response; and

generating a warning of anodal capture in response to the abnormal response not approximately matching the mean response.

4. The method of claim 3, wherein determining if the abnormal response approximately matches the mean response further comprises:

switching the polarity of an anode of the associated candidate bipole to a cathode polarity to establish a second candidate cathode;

measuring a second control response associated with the second candidate cathode and the universal anode;

measuring a bipolar response for each of a second plurality of candidate bipoles comprising the second candidate cathode;

classifying each of the second control response and the bipolar responses for each of the second plurality of candidate bipoles as one of normal and abnormal;

computing a mean response for the second candidate cathode using only those of the second control response and the bipolar responses for each of the second plurality of candidate bipoles that are classified as normal; and

determining that the abnormal response approximately matches the mean response for the first candidate cathode if the abnormal response is closer to the mean response for the first candidate cathode than the mean response for the second candidate cathode.

5. The method of claim 4, further comprising, if the abnormal response is closer to the mean response for the second candidate cathode, generating a warning of anodal capture for the associated candidate bipole.

6. The method of claim 1, further comprising, responsive to the first control response not meeting the threshold response classifying the first control response as abnormal;

and

generating a warning of anodal capture in response to classifying the first control response as abnormal.

7. The method of claim 6, further comprising:

comparing each of the bipolar responses to each other in response to the first control response being classified as abnormal; and

generating a warning of anodal capture for the candidate cathode if none of the bipolar responses are within the threshold range of each other.

8. The method of claim 7, further comprising:

classifying the bipolar responses in response to the comparing wherein a given bipolar response for an associated candidate bipole is classified as normal if the given bipolar response is within the threshold range of another bipolar response and classified as abnormal if the given bipolar response is not with the threshold range of at least one other bipolar response; and

computing a mean response for the candidate cathode using only the bipolar responses classified as normal.

9. The method of claim 8, further comprising:

comparing a bipolar response classified as abnormal to the mean response;

determining whether the bipolar response approximately matches the mean response; and

generating a warning of anodal capture for the associated candidate bipole in response to the abnormal bipolar response not approximately matching the mean response.

10. The method of claim 9 wherein determining whether the bipolar response approximately matches the mean response comprises:

switching the polarity of an anode of the associated candidate bipole to a cathode polarity to establish a second candidate cathode;

measuring a second control response associated with the second candidate cathode and the universal anode;

measuring a bipolar response for each of a second plurality of candidate bipoles comprising the second candidate cathode;

classifying each of the second control response and the bipolar responses for each of the second plurality of candidate bipoles as one of normal and abnormal;

computing a mean response for the second candidate cathode using only those of the second control response and the bipolar responses for each of the second plurality of candidate bipoles that are classified as normal; and

determining that the abnormal response approximately matches the mean response for the first candidate cathode if the abnormal response is closer to the mean response for the first candidate cathode than the mean response for the second candidate cathode.

11. The method of claim 1, wherein measuring the first control response comprises measuring a conduction time.

12. A medical device for discriminating between cathodal and anodal cardiac capture, comprising:

a plurality of electrodes for sensing cardiac signals and delivering cardiac pacing pulses;

a therapy delivery module for delivering cardiac pacing pulses to a patient'"'"'s heart via the plurality of electrodes;

cardiac signal sensing circuitry for receiving signals from the plurality of electrodes;

a memory storing an established threshold response and an established threshold range; and

a controller configured to;

control the therapy delivery module to deliver a first pacing pulse using a first candidate cathode electrode positioned along a heart chamber and a universal anode;

measure a first control response to the first pacing pulse;

control the therapy delivery module to deliver a plurality of second pacing pulses using a plurality of candidate bipoles comprising the first candidate cathode electrode paired with each of a plurality of anodes positioned along the heart chamber;

measure a bipolar response to the second pacing pulses for each of the plurality of candidate bipoles;

compare the first control response to the threshold response;

responsive to the first control response meeting the threshold response, classifying the first control response as normal and comparing each of the bipolar responses to the first control response; and

classify each of the bipolar responses for the plurality of candidate bipoles, wherein a given bipolar response for an associated candidate bipole of the plurality of bipoles is classified as normal if the given bipolar response is within the threshold range of the first control response and classified as abnormal if the given bipolar response is outside the threshold range of the first control response.

13. The device of claim 12, wherein the controller is further configured to detect cathodal capture at the candidate cathode in response to all of the bipolar responses being classified as normal.

14. The device of claim 12, wherein the controller is further configured to:

responsive to classifying a bipolar response as abnormal for an associated candidate bipole, compute a mean response for the candidate cathode using the normal first control response and all bipolar responses classified as normal;

determine if the abnormal conduction time approximately matches the mean response; and

generate a warning of anodal capture in response to the abnormal response not approximately matching the mean response.

15. The device of claim 14, wherein determining if the abnormal response approximately matches the mean response further comprises:

switching the polarity of an anode of the associated candidate bipole to a cathode polarity to establish a second candidate cathode;

measuring a second control response associated with the second candidate cathode and the universal anode;

measuring a bipolar response for each of a second plurality of candidate bipoles comprising the second candidate cathode;

classifying each of the second control response and the bipolar responses for each of the second plurality of candidate bipoles as one of normal and abnormal;

computing a mean response for the second candidate cathode using only those of the second control response and the bipolar responses for each of the second plurality of candidate bipoles that are classified as normal; and

determining that the abnormal response approximately matches the mean response for the first candidate cathode if the abnormal response is closer to the mean response for the first candidate cathode than the mean response for the second candidate cathode.

16. The device of claim 15, wherein the controller is further configured to generate a warning of anodal capture for the associated candidate bipole if the abnormal response is closer to the mean response for the second candidate cathode.

17. The device of claim 12, wherein the controller is further configured to:

classify the first control response as abnormal if the first control response does not meet the threshold response; and

generate a warning of anodal capture in response to classifying the first control response as abnormal.

18. The device of claim 17, wherein the controller is further configured to:

compare each of the bipolar responses to each other in response to the first control response being classified as abnormal; and

generate a warning of anodal capture for the candidate cathode if none of the bipolar responses are within the threshold range of each other.

19. The device of claim 18, wherein the controller is further configured to:

classify the bipolar responses in response to the comparing, wherein a given bipolar response for an associated candidate bipole is classified as normal if the given bipolar response is within the threshold range of another bipolar response and classified as abnormal if the given bipolar response is not with the threshold range of another bipolar response; and

compute a mean response for the candidate cathode using only the bipolar responses classified as normal.

20. The device of claim 19, wherein the controller is further configured to:

compare a bipolar response classified as abnormal to the mean response;

determine whether the bipolar response approximately matches the mean response; and

generate a warning of anodal capture for the associated candidate bipole in response to the bipolar response not approximately matching the mean response.

21. The device of claim 20 wherein determining whether the bipolar response approximately matches the mean response comprises:

switching the polarity of an anode of the associated candidate bipole to a cathode polarity to establish a second candidate cathode;

measuring a second control response associated with the second candidate cathode and the universal anode;

measuring a bipolar response for each of a second plurality of candidate bipoles comprising the second candidate cathode;

classifying each of the second control response and the bipolar responses for each of the second plurality of candidate bipoles as one of normal and abnormal;

computing a mean response for the second candidate cathode using only those of the second control response and the bipolar responses for each of the second plurality of candidate bipoles that are classified as normal; and

determining that the abnormal response approximately matches the mean response for the first candidate cathode if the abnormal response is closer to the mean response for the first candidate cathode than the mean response for the second candidate cathode.

22. The device of claim 12, wherein measuring the first control response comprises measuring a conduction time.

23. A non-transitory computer-readable medium storing a set of instructions which when implemented in a medical device cause the device to perform a method for discriminating between cathodal and anodal cardiac capture, the method comprising:

delivering a first pacing pulse using a first candidate cathode electrode positioned along a heart chamber and a universal anode;

measuring a first control response to the first pacing pulse;

delivering a plurality of second pacing pulses using a plurality of candidate bipoles comprising the first candidate cathode electrode paired one at a time with each of a plurality of anodes positioned along the heart chamber;

measuring a bipolar response to the second pacing pulses for each of the plurality of candidate bipoles;

establishing a threshold response and a threshold range;

comparing the first control response to the threshold response;

responsive to the first control response meeting the threshold response, classifying the first control response as normal and comparing each of the bipolar responses to the first control response; and

classifying each of the bipolar responses for the plurality of candidate bipoles, wherein a given bipolar response for an associated candidate bipole of the plurality of bipoles is classified as normal if the given bipolar response is within the threshold range of the first control response and classified as abnormal if the bipolar response is outside the threshold range of the first control response.