Rejuvenation or preservation of germ cells

• US 8,527,209 B2
• Filed: 06/24/2010
• Issued: 09/03/2013
• Est. Priority Date: 06/24/2010
• Status: Expired due to Fees

• Current Assignee: Enterprise Science Fund, LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Jung, Edward K. Y., Wood, Lowell L. Jr.
• Primary Examiner(s): Brusca, John S
• Application Number:
  US12/803,447
• Publication Number:
  US 20110319807A1
• Time in Patent Office: 1,167 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61K 35/54 Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives

Abstract

Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ cells or gametes. Certain embodiments disclosed herein include, but are not limited to, methods of modifying germ cells or gametes, or methods of administering modified germ cells or gametes to at least one biological tissue.

Claims

1. A system, comprising:

at least one computing device;

at least one delivery device configured to receive, retain and dispense at least a portion of a composition including at least one energy supplying factor to at least one reproductive cell by way of liposomal endocytosis or electroporation, the at least one energy supplying factor including one or more of creatine, phosphocreatine, NADH, FADH₂ or ATP; and

a recordable medium including one or more instructions that when executed on the computing device cause the computing device to regulate dispensing of at least a portion of the composition;

wherein the at least one computing device includes at least one computing device located on or in the at least one delivery device.

2. The system of claim 1, wherein the at least one delivery device includes at least one implantable delivery device.

3. The system of claim 1, wherein the at least one computing device includes at least one computing device located remotely from the at least one delivery device.

4. The system of claim 1, wherein the at least one computing device includes one or more of a desktop computer, workstation computer, or computing system.

5. The system of claim 1, wherein the at least one computing system includes one or more of a cluster of processors, networked computer, tablet personal computer, laptop computer, mobile device, mobile telephone, or personal digital assistant computer.

6. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to generate at least one output to a user.

7. The system of claim 6, wherein the at least one output includes at least one graphical illustration of one or more of the composition, at least one reproductive cell or substance associated with the composition, at least one property of the delivery device;

or at least one property of dispensing the at least one delivery device.

8. The system of claim 6, wherein the at least one output includes at least one protocol for making the composition.

9. The system of claim 6, wherein the at least one output includes at least one protocol for administering the composition to the at least one reproductive cell.

10. The system of claim 6, wherein the user includes at least one entity.

11. The system of claim 10, wherein the entity includes at least one person, or computer.

12. The system of claim 6, wherein the output includes output to a user readable display.

13. The system of claim 12, wherein the user readable display includes a human readable display.

14. The system of claim 12, wherein the user readable display includes one or more active displays.

15. The system of claim 12, wherein the user readable display includes one or more passive displays.

16. The system of claim 12, wherein the user readable display includes one or more of a numeric format, graphical format, or audio format.

17. The system of claim 1, further comprising one or more instructions for determining one or more parameters for selecting the at least one reproductive cell from other reproductive cells.

18. The system of claim 1, further comprising one or more instructions for determining one or more parameters for administering the composition to at least one reproductive cell.

19. The system of claim 1, further comprising one or more instructions for receiving information related to one or more reproductive cell indicators prior to, during, or subsequent to administering the composition to the at least one reproductive cell.

20. The system of claim 19, wherein the information related to one or more reproductive cell indicators includes information from at least one of an assay, image, or gross assessment of the at least one reproductive cell or reproductive cell related tissue prior to, during, or subsequent to administering the composition.

21. The system of claim 20, wherein the assay includes at least one technique including spectroscopy, microscopy, electrochemical detection, polynucleotide detection, histological examination, biopsy analysis, fluorescence resonance energy transfer, electron transfer, enzyme assay, electrical conductivity, isoelectric focusing, chromatography, immunoprecipitation, immunoseparation, aptamer binding, filtration, electrophoresis, immunoassay, or radioactive assay.

22. The system of claim 20, wherein the at least one image includes one or more images acquired by at least one of laser, holography, x-ray crystallography, optical coherence tomography, computer-assisted tomography scan, computed tomography, magnetic resonance imaging, positron-emission tomography scan, ultrasound, x-ray, electrical-impedance monitoring, microscopy, spectrometry, flow cytommetry, radioisotope imaging, thermal imaging, infrared visualization, multiphoton calcium-imaging, photography, or in silico generation.

23. The system of claim 1, wherein the at least one reproductive cell is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

24. The system of claim 1, wherein the at least one reproductive cell is located in at least one subject.

25. The system of claim 24, wherein the at least one subject includes at least one of an invertebrate or vertebrate animal.

26. The system of claim 24, wherein the at least one subject includes at least one of a reptile, mammal, amphibian, bird, or fish.

27. The system of claim 24, wherein the at least one subject includes at least one human.

28. A system, comprising:

at least one computing device;

at least one delivery device configured to receive, retain and dispense at least a portion of a composition including at least one energy supplying factor to at least one reproductive cell by way of liposomal endocytosis or electroporation, the at least one energy supplying factor including one or more of creatine. phosphocreatine, NADH, FADH₂, or ATP; and

a recordable medium including one or more instructions that when executed on the computing device cause the computing device to regulate dispensing of at least a portion of the composition;

wherein the at least one reproductive cell is located in at least one subject.

29. The system of claim 28, wherein the at least one delivery device includes at least one implantable delivery device.

30. The system of claim 28, wherein the at least one computing device includes at least one computing device located remotely from the at least one delivery device.

31. The system of claim 28, wherein the at least one computing device includes one or more of a desktop computer, workstation computer, or computing system.

32. The system of claim 28, wherein the at least one computing system includes one or more of a cluster of processors, networked computer, tablet personal computer, laptop computer, mobile device, mobile telephone, or personal digital assistant computer.

33. The system of claim 28, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to generate at least one output to a user.

34. The system of claim 33, wherein the at least one output includes at least one graphical illustration of one or more of the composition, at least one reproductive cell or substance associated with the composition, at least one property of the delivery device;

or at least one property of dispensing the at least one delivery device.

35. The system of claim 33, wherein the at least one output includes at least one protocol for making the composition.

36. The system of claim 33, wherein the at least one output includes at least one protocol for administering the composition to the at least one reproductive cell.

37. The system of claim 33, wherein the user includes at least one entity.

38. The system of claim 37, wherein the entity includes at least one person, or computer.

39. The system of claim 28, wherein the output includes output to a user readable display.

40. The system of claim 39, wherein the user readable display includes a human readable display.

41. The system of claim 39, wherein the user readable display includes one or more active displays.

42. The system of claim 39, wherein the user readable display includes one or more passive displays.

43. The system of claim 39, wherein the user readable display includes one or more of a numeric format, graphical format, or audio format.

44. The system of claim 28, further comprising one or more instructions for determining one or more parameters for selecting the at least one reproductive cell from other reproductive cells.

45. The system of claim 28, further comprising one or more instructions for determining one or more parameters for administering the composition to at least one reproductive cell.

46. The system of claim 28, further comprising one or more instructions for receiving information related to one or more reproductive cell indicators prior to, during, or subsequent to administering the composition to the at least one reproductive cell.

47. The system of claim 46, wherein the information related to one or more reproductive cell indicators includes information from at least one of an assay, image, or gross assessment of the at least one reproductive cell or reproductive cell related tissue prior to, during, or subsequent to administering the composition.

48. The system of claim 47, wherein the assay includes at least one technique including spectroscopy, microscopy, electrochemical detection, polynucleotide detection, histological examination, biopsy analysis, fluorescence resonance energy transfer, electron transfer, enzyme assay, electrical conductivity, isoelectric focusing, chromatography, immunoprecipitation, immunoseparation, aptamer binding, filtration, electrophoresis, immunoassay, or radioactive assay.

49. The system of claim 28, wherein the at least one reproductive cell is located in at least one of in situ, in vitro, in vivo, in utero, in silico, or ex vivo.