Applicators and methods for intraoperative treatment of proliferative diseases of the breast

• US 8,529,427 B2
• Filed: 10/11/2012
• Issued: 09/10/2013
• Est. Priority Date: 05/30/2008
• Status: Active Grant

• Current Assignee: Nucletron Operations BV
• Original Assignee: Xoft Incorporated (iCAD Incorporated)
• Inventors: Francescatti, Darius, Jervis, James E.
• Primary Examiner(s): Matthews, Christine
• Assistant Examiner(s): LANNU, JOSHUA DARYL DEANON
• Application Number:
  US13/649,257
• Publication Number:
  US 20130035536A1
• Time in Patent Office: 334 Days
• Field of Search: 600/1, 600/3
• US Class Current: 600/3
• CPC Class Codes: A61N 5/1015 Treatment of resected cavities created by surgery, e.g. lumpectomy
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1083 Robot arm beam systems

Abstract

A device for administering brachytherapy to a patient includes a vessel that may be in the form of a hollow cylindrical cup, for fleshing into and substantially filling the open-ended cavity. The vessel has a closed outer end, which may be a removable cover, and a source guide penetrates the closed outer end so as to extend deep into the vessel, to receive a radiation source in the source guide. A manipulator can be connected to the radiation source, and also to the source guide, for allowing several different types of manipulation of the source orientation and position within the vessel during the brachytherapy procedure.

Claims

1. A device for administering brachytherapy to the tissue of a living patient, comprising:

a cup of a material at least partially transparent to x-ray radiation and having a longitudinal cup axis;

a lid for threaded engagement with the cup and including a peripheral threaded downwardly depending section having a free end;

a source guide for receiving an x-ray source attached to and penetrating through the lid of the cup and extending along a source guide longitudinal axis that is coincident with the longitudinal cup axis;

a catheter carrying an x-ray source slidable within the source guide in the cup;

wherein the cup can be positioned in an open resection cavity so that the catheter can be manipulated axially within the source guide in the cup;

a manipulator for moving the source guide so that the x-ray source can be moved to different positions within the cup during the brachytherapy treatment; and

a skirt formed integrally with the lid and extending coaxially with the cup axis;

said skirt formed as a downwardly depending annular wall member having a free lower end that terminates at substantially the same location as the peripheral threaded downwardly depending section free end of the lid;

wherein the skirt is constructed of an attenuating material to protect the skin of the patient against radiation.

2. The device of claim 1 wherein the peripheral threaded downwardly depending section of the skirt is disposed within the cup.

3. The device of claim 1 wherein the lid has threads that are internal and the cup has threads that are external.

4. A device for administering brachytherapy to the tissue of a living patient, comprising:

a vessel formed of a material at least partially transparent to x-ray radiation, with a substantially closed outer end on the vessel and an internal chamber;

a source guide having proximal and distal ends with the proximal end disposed outside of the vessel and the distal end extending into the vessel, the source guide for receiving an x-ray source and extending along a source guide longitudinal axis;

a catheter carrying an x-ray source and positioned within the source guide in the vessel, wherein the vessel can be positioned in an open resection cavity, and with the x-ray source positioned within the source guide in the vessel so that brachytherapy treatment can be administered to tissues surrounding the vessel; and

a manipulator for moving the source guide so that the x-ray source is moved to different lateral positions within the internal chamber of the vessel during the brachytherapy treatment so as to cover a total chamber coverage area that is greater than the area of the source guide itself;

said manipulator constructed and arranged for lateral movement that is substantially transverse to the source guide longitudinal axis.

5. The device of claim 4 wherein the vessel is comprised of a cup and cover having a common longitudinal vessel axis that is coincident with the source guide axis.

6. The device of claim 5 wherein the manipulator includes provision for moving the source guide in at least one of X and Y directions of translation within the cup, the X and Y directions being parallel to the cover, so that the x-ray source can be moved to different positions within the cup during the brachytherapy treatment.

7. The device of claim 5 wherein the manipulator includes provision for moving the source guide in X and Y directions of translation within the cup, the X and Y directions being parallel to the cover, so that the x-ray source can be moved to essentially any position within the cup during the brachytherapy treatment.

8. The device of claim 4 wherein the manipulator controls the source guide to different lateral positions that are parallel to the vessel closed outer end.

9. The device of claim 4 wherein the manipulator is constructed and arranged for pivotally supporting the source guide for control of a pivot angle of the source guide.

10. A device for administering brachytherapy to the tissue of a living patient, comprising:

a vessel formed of a material at least partially transparent to x-ray radiation, with a substantially closed outer end on the vessel and an internal chamber;

a source guide having proximal and distal ends with the proximal end disposed outside of the vessel and the distal end extending into the vessel, the source guide for receiving an x-ray source and extending along a source guide longitudinal axis;

a catheter carrying an x-ray source and positioned within the source guide in the vessel, wherein the vessel can be positioned in an open resection cavity, and with the x-ray source positioned within the source guide in the vessel so that brachytherapy treatment can be administered to tissues surrounding the vessel; and

a manipulator for moving the source guide so that the x-ray source is moved to different lateral positions within the internal chamber of the vessel during the brachytherapy treatment so as to cover a total area that is greater than the area treated when the source guide is stationary;

said manipulator constructed and arranged for lateral movement that is substantially transverse to the source guide longitudinal axis.

11. The device of claim 10 wherein the vessel is comprised of a cup and cover having a common longitudinal vessel axis that is coincident with the source guide axis.

12. The device of claim 11 wherein the manipulator includes provision for moving the source guide in at least one of X and Y directions of translation within the cup, the X and Y directions being parallel to the cover, so that the x-ray source can be moved to different positions within the cup during the brachytherapy treatment.

13. The device of claim 11 wherein the manipulator includes provision for moving the source guide in X and Y directions of translation within the cup, the X and Y directions being parallel to the cover, so that the x-ray source can be moved to essentially any position within the cup during the brachytherapy treatment.

14. The device of claim 10 wherein the manipulator controls the source guide to different lateral positions that are parallel to the vessel closed outer end.

15. The device of claim 10 wherein the manipulator includes a pivot arm for supporting the source guide for control of a pivot angle of the source guide.