Methods of controlling magnetic nanoparticles to improve vascular flow
First Claim
1. A method of increasing fluid flow within vasculature of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the vasculature, the method comprising:
- introducing a therapeutic agent within vasculature of a subject, the therapeutic agent configured to have a therapeutic effect on a therapeutic target within the vasculature;
administering a therapeutically effective amount of magnetic nanoparticles within the vasculature,causing a magnet external to the vasculature to generate a rotating magnetic field and a directed magnetic gradient in a manner sufficient to cause the magnetic nanoparticles to agglomerate to form a plurality of magnetic nanoparticle rods within the vasculature and to travel within the vasculature toward a therapeutic target in an end over end walking motion in response to the rotating magnetic field and the directed magnetic gradient of the magnet; and
causing the magnetic nanoparticle rods to generate a circulating fluid motion within the vasculature proximal to the therapeutic target by adjusting at least one parameter selected from the group consisting of;
a rotational frequency of the rotating magnetic field, a plane of the rotating magnetic field with respect to the therapeutic target, and a distance of the rotating magnetic field with respect to the therapeutic target,wherein the circulating fluid motion facilitates contact of the therapeutic agent with the therapeutic target by enhancing diffusion of the therapeutic agent to the region of the blood vessel proximal to the therapeutic target and by refreshing contact of the therapeutic target with the therapeutic agent, thereby providing more effective interaction of the therapeutic agent with the therapeutic target.
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Abstract
Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
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Citations
22 Claims
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1. A method of increasing fluid flow within vasculature of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the vasculature, the method comprising:
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introducing a therapeutic agent within vasculature of a subject, the therapeutic agent configured to have a therapeutic effect on a therapeutic target within the vasculature; administering a therapeutically effective amount of magnetic nanoparticles within the vasculature, causing a magnet external to the vasculature to generate a rotating magnetic field and a directed magnetic gradient in a manner sufficient to cause the magnetic nanoparticles to agglomerate to form a plurality of magnetic nanoparticle rods within the vasculature and to travel within the vasculature toward a therapeutic target in an end over end walking motion in response to the rotating magnetic field and the directed magnetic gradient of the magnet; and causing the magnetic nanoparticle rods to generate a circulating fluid motion within the vasculature proximal to the therapeutic target by adjusting at least one parameter selected from the group consisting of;
a rotational frequency of the rotating magnetic field, a plane of the rotating magnetic field with respect to the therapeutic target, and a distance of the rotating magnetic field with respect to the therapeutic target,wherein the circulating fluid motion facilitates contact of the therapeutic agent with the therapeutic target by enhancing diffusion of the therapeutic agent to the region of the blood vessel proximal to the therapeutic target and by refreshing contact of the therapeutic target with the therapeutic agent, thereby providing more effective interaction of the therapeutic agent with the therapeutic target. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of increasing fluid flow within a cerebral blood vessel of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the subject, the method comprising:
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introducing a thrombolytic agent within vasculature of a subject, the thrombolytic agent configured to facilitate lysis of a clot within a cerebral blood vessel; administering a therapeutically effective amount of magnetic nanoparticles within the vasculature; causing a magnet external to the vasculature to generate a rotating magnetic field and a directed magnetic gradient in a manner sufficient to cause the magnetic nanoparticles to agglomerate to form a plurality of magnetic nanoparticle rods within the vasculature and to travel within the vasculature toward the clot within the cerebral blood vessel in an end over end motion in response to the rotating magnetic field and the directed magnetic gradient of the magnet; and causing the magnetic nanoparticle rods to generate a circulating fluid motion within the vasculature proximal to the clot by adjusting at least one parameter selected from the group consisting of;
a frequency of the rotating magnetic field, a plane of the rotating magnetic field with respect to the clot, and a distance of the rotating magnetic field with respect to the clot, thereby increasing contact of the therapeutic agent with the clot. - View Dependent Claims (13, 14, 15, 16)
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17. A method of increasing fluid flow within vasculature of a subject through external magnetomotive manipulation of magnetic nanoparticles introduced within the vasculature, the method comprising:
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applying a magnetic field and a directed magnetic gradient of a magnet to a plurality of coated magnetic nanoparticles introduced within vasculature of a subject; rotating the magnetic field at a first rotational frequency effective to agglomerate the magnetic nanoparticles into a plurality of magnetic nanoparticle rods in response to the rotating magnetic field and the directed gradient; rotating the magnetic field at a second rotational frequency effective to move the magnetic nanoparticle rods along the vasculature in an end-over-end manner toward a therapeutic target in response to the rotating magnetic field and the directed gradient; and causing the magnetic nanoparticle rods to generate a circulating fluid motion within fluid proximal to the therapeutic target, thereby enhancing diffusion of a therapeutic agent to the therapeutic target and facilitating exposure of the therapeutic agent to the therapeutic target in response to the rotating magnetic field and the directed gradient. - View Dependent Claims (18, 19, 20, 21, 22)
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Specification