Implant delivery catheter system and methods for its use

• US 8,529,550 B2
• Filed: 12/06/2005
• Issued: 09/10/2013
• Est. Priority Date: 04/05/2000
• Status: Expired due to Fees

• Current Assignee: BioCardia, Inc
• Original Assignee: BioCardia, Inc
• Inventors: Rosenman, Daniel C., Altman, Peter A., Lovich, Mark A., Schwartz, Michael A., Miller, Aaron J.
• Primary Examiner(s): Mehta, Bhisma
• Application Number:
  US11/295,412
• Publication Number:
  US 20060084943A1
• Time in Patent Office: 2,835 Days
• Field of Search: 604/22, 604/48, 604 57- 60, 604/73, 604/93.01, 604/95.01, 604/164.01, 604/181, 604/187, 604/264, 604/523, 604/890.1, 604/891.1, 607/120, 607/126, 607/127
• US Class Current: 604/890.1
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61N 1/0568 with drug delivery
• CPC Class Codes: A61N 2001/0578 having means for removal or extraction

Abstract

Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.

Claims

1. A catheter system comprising:

a catheter having a proximal end and a distal end;

a drug delivery structure disposed on the distal end of the catheter, where the structure is a hollow structure with one or more apertures communicating from the interior to the exterior of said hollow structure, and a reservoir of a therapeutic agent within said drug delivery structure, said therapeutic agent comprising one of antagonists to angiogenic agents, cytotoxic agents, anti-Her-2, and anti CD20, and tumor necrosis factors;

said drug delivery structure being disengageable from the distal end of the catheter;

a mechanism at the proximal end of the catheter for disengaging said drug delivery structure from the distal end of the catheter; and

a fixation means on said drug delivery structure that may be used within a body of a patient to implant the drug delivery structure to a depth within an intended tissue within the body of a patient.

2. The system of claim 1 wherein the drug delivery structure is a helical structure.

3. The system of claim 1 wherein the drug delivery structure is a dart structure.

4. The system of claim 1 wherein the apertures comprise slots or circular holes sized and positioned to control a rate of diffusion of the therapeutic agent from the drug delivery structure.

5. The system of claim 1 wherein the drug delivery structure comprises a porous construction capable of wicking up the therapeutic fluid through capillary action.

6. The system of claim 1 wherein the therapeutic agent comprises a controlled release formulation.

7. The system of claim 1 wherein the therapeutic agent is disposed within a polymer carrier.

8. The system of claim 1 wherein the therapeutic agent is disposed within a powder.

9. The system of claim 1 wherein the therapeutic agent is disposed within a controlled release structure.

10. The system of claim 9 wherein the controlled release structure comprises EVAC.