Intraocular implants and related kits and methods

• US 8,529,622 B2
• Filed: 02/03/2011
• Issued: 09/10/2013
• Est. Priority Date: 02/05/2010
• Status: Active Grant

• Current Assignee: Sight Sciences, Inc.
• Original Assignee: Sight Sciences, Inc.
• Inventors: Badawi, David Y., Badawi, Paul
• Primary Examiner(s): Matthews, William H
• Application Number:
  US13/020,706
• Publication Number:
  US 20110196487A1
• Time in Patent Office: 950 Days
• Field of Search: 604/8, 623/4.1, 623/23.69
• US Class Current: 623/4.1
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61F 2/15 Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2210/0014 using shape memory or superelastic materials, e.g. nitinol
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm'"'"'s canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm'"'"'s canal. Methods may include implanting a support within Schlemm'"'"'s canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

Claims

1. A device for reducing intraocular pressure comprising:

a twisted ribbon member implantable circumferentially within at least a portion of Schlemm'"'"'s canal and configured to restore or maintain at least partial patency of at least a portion of Schlemm'"'"'s canal,

wherein the twisted ribbon member comprises a double helix having a length, a first elongated edge, a second elongated edge, and a central longitudinal axis, the first and second elongated edges of the double helix being twisted along and about the central longitudinal axis, and comprising a plurality of struts extending therebetween in a direction substantially normal to the central longitudinal axis, and wherein the plurality of struts define a plurality of fenestrations spaced along at least a portion of the length of the twisted ribbon member.

2. The device of claim 1, wherein the first and second elongated edges are configured to contact an interior surface of Schlemm'"'"'s canal when the device is implanted in Schlemm'"'"'s canal.

3. The device of claim 2, wherein the first and second elongated edges are configured to continuously contact the interior surface of Schlemm'"'"'s canal when the device is implanted in Schlemm'"'"'s canal.

4. The device of claim 1, wherein the device does not substantially interfere with transmural flow across Schlemm'"'"'s canal when the device is implanted in Schlemm'"'"'s canal.

5. The device of claim 1, wherein the twisted ribbon member comprises a shape memory alloy.

6. The device of claim 5, wherein the shape memory alloy comprises a nickel-titanium alloy.

7. The device of claim 1, wherein the twisted ribbon member comprises a metal alloy.

8. The device of claim 7, wherein the metal alloy comprises stainless steel.

9. The device of claim 1, wherein the twisted ribbon member comprises a metal.

10. The device of claim 9, wherein the metal comprises titanium.