Diagnostic and treatment methods for characterizing bacterial microbiota in skin conditions

• US 8,529,892 B2
• Filed: 02/24/2011
• Issued: 09/10/2013
• Est. Priority Date: 07/31/2007
• Status: Active Grant

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: Gao, Zhan, Blaser, Martin J.
• Primary Examiner(s): Navarro, Albert
• Assistant Examiner(s): Portner, Ginny
• Application Number:
  US13/034,359
• Publication Number:
  US 20120171193A1
• Time in Patent Office: 929 Days
• Field of Search: None
• US Class Current: 424/130.1
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: C12Q 1/04 Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor C12Q1/6897 takes precedence
• CPC Class Codes: C12Q 1/14 Streptococcus; Staphylococcus
• CPC Class Codes: G01N 2800/205 Scaling palpular diseases, e.g. psoriasis, pytiriasis

Abstract

The present invention relates to methods for characterization of bacterial skin microbiota to provide diagnostic, therapeutic, and preventive measures for alleviating skin conditions. In certain embodiments, the invention relates to characterization of bacterial skin microbiota associated with psoriasis and related diagnostic, therapeutic, and preventive measures for alleviating psoriasis. These methods will be useful for detecting, diagnosing, and monitoring individuals who have or are at risk of certain skin conditions.

Claims

1. A method for treating psoriasis in a patient in need of such treatment comprising topically administering to a psoriatic skin lesion in the patient an effective amount of live, inactivated or killed Propionibacterium cells.

2. The method of claim 1, wherein the Propionibacterium cells are Propionibacterium acnes cells.

3. The method of claim 1, further comprising administering a prebiotic to the patient.

4. The method of claim 1, wherein said Propionibactium cells are formulated into a cream, an ointment, a lotion, or a salve.

5. The method of claim 1, further comprising administering said Propionibacterium cells to affected skin in said psoriasis patient.

6. A method for treating psoriasis in a patient in need of such treatment comprising topically administering to a psoriatic skin lesion in the patient an effective amount of an extract from Propionibacterium.

7. The method of claim 6, wherein the Propionibacterium is Propionibacterium acnes.

8. The method of claim 6, further comprising administering a prebiotic to the patient.

9. The method of claim 6, wherein said extract from Propionibactium is formulated into a cream, an ointment, a lotion, or a salve.

10. The method of claim 6, further comprising administering said Propionibacterium extract to affected skin in said psoriasis patient.