Bicyclic cyclohexitol nucleic acid analogs
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Abstract
The present disclosure provides bicyclic cyclohexitol nucleoside analogs of formula I and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are expected to be useful for enhancing properties of oligomeric compounds including for example nuclease resistance.
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42 Claims
- 1. A bicyclic nucleoside analog having formula I:
- 25. An oligomeric compound comprising at least one bicyclic nucleoside analog having formula III:
Specification