Laser self-mixing sensors for biological sensing
First Claim
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1. A method for monitoring blood pressure, comprising:
- receiving a first and second self-mixed laser Doppler signal, wherein the first laser signal represents at least in part a flow velocity of blood through a blood vessel and the second laser signal represents at least in part the movement of a blood vessel wall;
deriving, based at least in part on the first laser signal, the blood flow velocity;
deriving, based at least in part on the second laser signal, a compliance of the blood vessel wall; and
calculating, based at least in part on the derived flow velocity and the derived compliance, a blood pressure value using a processor.
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Abstract
According to embodiments, systems, devices, and methods for biological sensing with laser self-mixing sensors are disclosed. In one embodiment, one or more self-mixed laser Doppler signals may be used to detect blood flow velocity or blood vessel wall velocity. In one embodiment, a blood vessel wall compliance may be derived from the blood vessel wall velocity. In one embodiment, blood pressure may be calculated based at least in part on blood flow velocity or based at least in part on blood flow velocity and blood vessel compliance. In one embodiment, common mode noise may be removed from one or more laser signals.
225 Citations
31 Claims
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1. A method for monitoring blood pressure, comprising:
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receiving a first and second self-mixed laser Doppler signal, wherein the first laser signal represents at least in part a flow velocity of blood through a blood vessel and the second laser signal represents at least in part the movement of a blood vessel wall; deriving, based at least in part on the first laser signal, the blood flow velocity; deriving, based at least in part on the second laser signal, a compliance of the blood vessel wall; and calculating, based at least in part on the derived flow velocity and the derived compliance, a blood pressure value using a processor. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for determining blood vessel compliance, comprising:
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receiving at least two self-mixed laser Doppler signals, wherein the at least two laser signals represent at least in part the movement of a blood vessel wall and penetrate the blood vessel wall to at least two different depths, wherein the at least two laser signals represent movement of the same blood vessel; and automatically deriving, based at least in part on the at least two laser signals, a compliance of the blood vessel wall using a processor. - View Dependent Claims (8, 9, 16)
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10. A device for monitoring blood pressure, the device comprising:
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a plurality of self-mixed laser sensors capable of producing at least first and second self-mixed laser signals corresponding to laser measurements; and a processor configured to;
receive the first signal and the second signal from the plurality of self-mixed laser sensors, wherein the first signal represents at least in part a flow velocity of blood through a blood vessel;derive, based at least in part on the first signal, the blood flow velocity; derive, based at least in part on the second laser signal, a compliance of the blood vessel wall; and calculate, based at least in part on the derived flow velocity and the derived compliance, a blood pressure value. - View Dependent Claims (11, 12, 13, 14, 15)
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17. A device for determining blood vessel wall compliance, the device comprising:
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a plurality of self-mixed laser sensors capable of producing at least two self-mixed laser signals corresponding to laser measurements, wherein the at least two laser signals and penetrate a blood vessel wall to at least two different depths; and a processor configured to;
receivethe first and second signals, wherein the at least two laser signals represent at least in part the movement of a blood vessel wall, wherein the at least two laser signals represent movement of the same blood vessel; and derive, based at least in part on the at least two signals, the compliance of the blood vessel wall. - View Dependent Claims (18, 19, 20, 21)
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22. A non-transitory computer readable medium storing computer executable instructions, which, when executed by a processor, cause the processor to carry out a method comprising:
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receiving a first and second self-mixed laser Doppler signal, wherein the first laser signal represents at least in part a flow velocity of blood through a blood vessel and the second laser signal represents at least in part the movement of a blood vessel wall; deriving, based at least in part on the first laser signal, the blood flow velocity; deriving, based at least in part on the second laser signal, a compliance of the blood vessel wall; and calculating, based at least in part on the derived flow velocity and the desired compliance, a blood pressure value. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A non-transitory computer readable medium storing computer executable instructions, which, when executed by a processor, cause the processor to carry out a method comprising:
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receiving at least two self-mixed laser Doppler signals, wherein the at least two laser signals represent at least in part the movement of the blood vessel wall and penetrate the blood vessel wall to at least two different depths, wherein the at least two laser signals represent movement of the same blood vessel; and deriving, based at least in part on the at least two laser signals, a compliance of the blood vessel wall. - View Dependent Claims (29, 30, 31)
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Specification