Microplate handling systems and related computer program products and methods

• US 8,534,447 B2
• Filed: 09/16/2009
• Issued: 09/17/2013
• Est. Priority Date: 09/16/2008
• Status: Expired due to Fees

• Current Assignee: Ibis Biosciences Incorporated
• Original Assignee: Ibis Biosciences Incorporated
• Inventors: Hofstadler, Steven A., Drader, Jared J., Gutierrez, Jose R., Gleason, Paul J., Bare, Rex O., Miller, Robert D., Smith, Jeffrey C., Oberkramer, Kevin S., Bergold, Ronald K.
• Primary Examiner(s): Singh, Kavel
• Application Number:
  US12/561,129
• Publication Number:
  US 20100070069A1
• Time in Patent Office: 1,462 Days
• Field of Search: None
• US Class Current: 198/347.1
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 35/0095 introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates

Abstract

Systems, computer program products, and methods useful for handling or managing microplates are provided.

Claims

1. A microplate handling system, comprising:

at least first and second non-priority microplate storage units that each store two or more microplates;

at least one priority microplate storage unit that stores at least one microplate;

at least one microplate processing area;

at least one non-priority microplate holding area;

at least one microplate transport mechanism configured to transport one or more microplates between the first and second non-priority microplate storage units, the priority microplate storage unit, the microplate processing area, and/or the non-priority microplate holding area; and

,

at least one controller operably connected at least to the microplate transport mechanism, which controller is configured to selectively direct the microplate transport mechanism to;

(a) transport a non-priority microplate from the first non-priority microplate storage unit to the microplate processing area;

(b) position the non-priority microplate while in the microplate processing area;

(c) transport the non-priority microplate from the microplate processing area to the non-priority microplate holding area when a priority microplate is stored in the priority microplate storage unit;

(d) transport the priority microplate from the priority microplate storage unit to the microplate processing area;

(e) position the priority microplate while in the microplate processing area;

(f) transport the priority microplate from the microplate processing area to the second non-priority microplate storage unit or to the priority microplate storage unit;

(g) transport the non-priority microplate from the non-priority microplate holding area to the microplate processing area; and

(h) transport the non-priority microplate from the microplate processing area to the second non-priority microplate storage unit.

2. The microplate handling system of claim 1, wherein the first and second non-priority microplate storage units each store two or more stacked microplates.

3. The microplate handling system of claim 1, wherein the controller is configured to selectively direct the microplate transport mechanism to execute (c) prior to (d) and/or (f) prior to (g).

4. The microplate handling system of claim 1, comprising at least one barcode reader or radio frequency identification (RFID) reader configured to read barcodes or radio frequency tags disposed on microplates when the microplates are disposed in or proximal to the first non-priority microplate storage unit, the second non-priority microplate storage unit, the priority microplate storage unit, the microplate processing area, and/or the non-priority microplate holding area.

5. The microplate handling system of claim 1, comprising at least one material transfer component configured to transfer material to and/or from selected wells disposed in at least one microplate when the microplate is disposed in the microplate processing area.

6. The microplate handling system of claim 5, wherein the material transfer component is configured to transfer fluidic material.

7. The microplate handling system of claim 5, comprising at least one magnetically responsive particle source, wherein the material transfer component is configured to aspirate an aliquot of magnetically responsive particles from the magnetically responsive particle source prior to or after aspirating an aliquot of material from a selected well of the microplate when the microplate is disposed in the microplate processing area.

8. The microplate handling system of claim 5, comprising at least one wash station configured to wash the material transfer component or a portion thereof.

9. The microplate handling system of claim 5, wherein the material transfer component comprises at least one gantry.

10. The microplate handling system of claim 5, comprising at least one sample processing component, wherein the material transfer component is configured to transfer the material from the selected wells disposed in the microplate to the sample processing component.

11. The microplate handling system of claim 10, wherein the sample processing component comprises a desalting station.

12. The microplate handling system of claim 5, wherein the material transfer component comprises at least one gantry head.

13. The microplate handling system of claim 12, wherein the material transfer component comprises one or more needles.

14. The microplate handling system of claim 1, wherein the first and second non-priority microplate storage units each comprise a support structure that defines a cavity that is configured to store two or more stacked microplates.

15. The microplate handling system of claim 14, wherein at least a lower surface of the support structure comprises an opening that communicates with the cavity, wherein dimensions of the opening are sufficient to accommodate microplates moving into or out of the cavity.

16. The microplate handling system of claim 14, comprising at least one retaining mechanism operably connected to the support structure, which retaining mechanism is configured to reversibly retain at least one microplate in the cavity.

17. The microplate handling system of claim 1, wherein the priority microplate storage unit comprises a support structure that defines a cavity that is configured to store the microplate.

18. The microplate handling system of claim 17, comprising at least one movement mechanism operably connected to the support structure, which movement mechanism is configured to move the support structure relative to the first and second non-priority microplate storage units.

19. The microplate handling system of claim 17, wherein at least a lower surface of the support structure comprises an opening that communicates with the cavity, wherein dimensions of the opening accommodate microplates moving into or out of the cavity.

20. The microplate handling system of claim 17, comprising at least one retaining mechanism operably connected to the support structure, which retaining mechanism is configured to reversibly retain at least one microplate in the cavity.

21. The microplate handling system of claim 1, comprising a support base on which the first and second non-priority microplate storage units, the priority microplate storage unit, the microplate processing area, and the non-priority microplate holding area are disposed.

22. The microplate handling system of claim 21, wherein the non-priority microplate holding area comprises at least one non-priority microplate holding component that is structured to hold one or more non-priority microplates above the support base.

23. The microplate handling system of claim 21, wherein at least the first and second non-priority microplate storage units are detachable from the support base.

24. The microplate handling system of claim 23, wherein the first and/or second non-priority microplate storage unit comprises a handle.

25. The microplate handling system of claim 1, wherein the microplate transport mechanism comprises:

at least one platform that is structured to support one or more microplates;

at least a first linear motion component operably connected to the platform, which first linear motion component selectively moves the platform along a first axis; and

,

at least a second linear motion component operably connected to the platform, which second linear motion component selectively moves the platform along a second axis.

26. The microplate handling system of claim 25, wherein the platform comprises a nest.

27. The microplate handling system of claim 25, wherein the first linear motion component is configured to selectively raise and lower the platform.

28. The microplate handling system of claim 25, wherein the first linear motion component comprises a stepper motor.

29. The microplate handling system of claim 25, wherein the second linear motion component is configured to selectively move the platform between the first non-priority microplate storage unit, the second non-priority microplate storage unit, the priority microplate storage unit, the microplate processing area, and/or the non-priority microplate holding area.

30. The microplate handling system of claim 25, wherein the second linear motion component is configured to move the platform beneath the first non-priority microplate storage unit, the second non-priority microplate storage unit, and the priority microplate storage unit.

31. The microplate handling system of claim 25, wherein the second linear motion component comprises at least one gantry.

32. The microplate handling system of claim 25, wherein the second linear motion component comprises at least one encoder and at least one stepper motor.