Multiple flow path microreactor design

• US 8,534,909 B2
• Filed: 09/28/2009
• Issued: 09/17/2013
• Est. Priority Date: 09/29/2008
• Status: Active Grant

• Current Assignee: Corning Incorporated
• Original Assignee: Corning Incorporated
• Inventors: Guidat, Roland, Lavric, Elena Daniela, Lobet, Olivier, Woehl, Pierre
• Primary Examiner(s): SOOHOO, TONY GLEN
• Application Number:
  US12/568,318
• Publication Number:
  US 20100078086A1
• Time in Patent Office: 1,450 Days
• Field of Search: 366/DIG.3, 366/341, 422/198, 422/503, 422/603
• US Class Current: 366/336
• CPC Class Codes: B01F 2025/915 Reverse flow, i.e. flow changing substantially 180° in direction
• CPC Class Codes: B01F 25/421 by moving the components in a convoluted or labyrinthine path B01F25/433 takes precedence
• CPC Class Codes: B01F 25/4317 Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
• CPC Class Codes: B01F 25/431971 Mounted on the wall
• CPC Class Codes: B01F 25/4321 the subflows consisting of at least two flat layers which are recombined, e.g. using means having restriction or expansion zones
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4331 Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
• CPC Class Codes: B01F 25/4338 Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/08 Regulating or influencing the flow resistance
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: Y10T 137/8593 Systems

Abstract

A microfluidic device comprises at least one reactant passage defined by walls and comprising at least one parallel multiple flow path configuration comprising a group of elementary design patterns being able to provide mixing and/or residence time which are arranged in series with fluid communication so as to constitute flow paths, and in parallel so as to constitute a multiple flow path elementary design pattern, wherein the parallel multiple flow path configuration comprises at least two communicating zones between elementary design patterns of two adjacent parallel flow paths, said communicating zones being in the same plane as that defined by said elementary design patterns between which said communicating zone is placed and allowing passage of fluid in order to minimize mass flow rate difference between adjacent parallel flow paths which have the same flow direction.

Claims

1. A microfluidic device comprising at least one reactant passage defined by walls and comprising at least one set of parallel paths, each parallel path of said at least one set of parallel paths comprising successive chambers with fluid communication therebetween, wherein the at least one set of parallel paths comprises at least two communicating zones between respective chambers of two adjacent parallel paths of the at least one set of parallel paths, said communicating zones lying along a common plane with said chambers between which said communicating zones are placed.

2. The microfluidic device according to claim 1 wherein at least two communicating zones are formed between all pairs of adjacent parallel paths of said at least one set of parallel flow paths.

3. The microfluidic device according to claim 1 wherein said communicating zones are formed between all adjacent chambers of said successive chambers of said at least one set of parallel paths.

4. The microfluidic device according to claim 1 wherein said communicating zones have a length ranging from 1.5 to 3.5 mm.

5. The microfluidic device according to claim 1 wherein said communicating zones have a ratio height/length ranging from 0.1 to 6 mm.

6. The microfluidic device according to claim 1 wherein the ratio between the width of said chambers, at the location of the respective communicating zones, and the length of said communicating zones is from 2 to 14.

7. The microfluidic device according to claim 1 wherein said chambers include a split of the reactant passage into at least two sub-passages, and a joining of the split passages, and a change of the passage direction, of at least one of the sub-passages, of at least 90 degrees.

8. The microfluidic device according to claim 1 wherein said reactant passage contains at least two sets of parallel paths placed in series.

9. The microfluidic device according to claim 8 wherein said at least two sets of parallel paths each comprise a number of flow paths, and wherein each comprises a different number of parallel paths.

10. The microfluidic device according to claim 1 said reactant passage is located within a reaction layer and wherein said microfluidic device further comprises one or more thermal control passages positioned and arranged within two thermal layers which are sandwiching said reaction layer without any fluid communication between said thermal control passages and said reactant passage.