Use of an equilibrium intravascular sensor to achieve tight glycemic control
First Claim
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1. A method for continuously monitoring blood glucose concentration in an ICU patient in need thereof, comprising:
- deploying an equilibrium glucose sensor in the patient, wherein the equilibrium glucose sensor comprises an indicator system comprising a fluorophore and a glucose binding moiety, wherein the indicator system is configured to generate an optical signal related to the blood glucose concentration; and
coupling the sensor to a monitor configured to detect the optical signal, and determine and display the ICU patient'"'"'s blood glucose concentration, and a rate and direction of change in the blood glucose concentration.
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Abstract
A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.
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34 Claims
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1. A method for continuously monitoring blood glucose concentration in an ICU patient in need thereof, comprising:
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deploying an equilibrium glucose sensor in the patient, wherein the equilibrium glucose sensor comprises an indicator system comprising a fluorophore and a glucose binding moiety, wherein the indicator system is configured to generate an optical signal related to the blood glucose concentration; and coupling the sensor to a monitor configured to detect the optical signal, and determine and display the ICU patient'"'"'s blood glucose concentration, and a rate and direction of change in the blood glucose concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification