Self-assembling cross-linking molecular nano film

• US 8,535,704 B2
• Filed: 12/29/2005
• Issued: 09/17/2013
• Est. Priority Date: 12/29/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Yang, Zhongping
• Primary Examiner(s): Foley, Shanon A
• Application Number:
  US11/322,055
• Publication Number:
  US 20070154519A1
• Time in Patent Office: 2,819 Days
• Field of Search: None
• US Class Current: 424/424
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

The present invention is a molecular nano film formed on a surface of an implantable medical device to provide a barrier to tissue attachment. The film comprises self-assembling cross-linking molecules.

Claims

1. An implantable medical device, comprising an external surface of platinum, titanium or platinum/iridium and a self-assembling, cross-linking molecular nano film that is applied over an area of the external surface to inhibit tissue attachment to the external surface, the film comprising interactive molecule chains of a fluorocarbon-alkyltrichlorosilane that create pores permitting ionic conductivity between the external surface and surrounding biological material.

2. The implantable medical device of claim 1, wherein the film comprises a monolayer.

3. The implantable medical device of claim 2, wherein the monolayer has a thickness in a range of about 2 nanometers to about 10 nanometers.

4. The implantable medical device of claim 2, wherein the film comprises a plurality of monolayers, thereby creating a multilayer film structure.

5. The implantable medical device of claim 1, wherein the film comprises pores with a pore size in a range of about 0.2 nanometers to about 500 nanometers.

6. The implantable medical device of claim 1, wherein the film comprises functional silane molecules deposited through at least one of molecular layer deposition, chemical vapor deposition, solution immersion, and combinations thereof.

7. A method of providing a conductive barrier to tissue attachment on an implantable medical device, the method comprising:

hydroxylating at least one platinum, titanium or platinum/iridium surface of the device; and

binding functional fluorocarbon-alkyltrichlorosilane molecules to the hydroxylated surface of the device, thereby forming a self-assembling cross-linking monolayer nano film.

8. The method of claim 7, wherein binding the functional silane molecules includes at least one of molecular layer deposition, chemical vapor deposition, solution immersion, and combinations thereof.

9. The method of claim 7, wherein each monolayer of the film has a thickness in a range of about 2 nanometers to about 10 nanometers.

10. The method of claim 7, wherein the film comprises a plurality of monolayers, thereby creating a multilayer film structure.