Devices and methods for delivering active agents to the osteomeatal complex

• US 8,535,707 B2
• Filed: 07/09/2007
• Issued: 09/17/2013
• Est. Priority Date: 07/10/2006
• Status: Active Grant

• Current Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Original Assignee: Intersect ENT, Inc. (Medtronic Plc)
• Inventors: Arensdorf, Patrick A., Biggs, Danielle L., Brenneman, Rodney, Downie, David B., Eaton, Donald J., Tice, Thomas R.
• Primary Examiner(s): Long, Scott
• Assistant Examiner(s): BECKHARDT, LYNDSEY MARIE
• Application Number:
  US11/775,157
• Publication Number:
  US 20090017090A1
• Time in Patent Office: 2,262 Days
• Field of Search: None
• US Class Current: 424/434
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.

Claims

1. A method for treating sinusitis or a related respiratory condition affecting the osteomeatal complex comprising placing a device comprising a single looped fiber having an active agent to treat the condition within the osteomeatal complex and delivering a therapeutically effective amount of the active agent locally to the osteomeatal complex over a sustained period of time, wherein the single looped fiber device is passively fixed in place via expansive tension.

2. The method of claim 1 wherein the related respiratory condition is selected from the group consisting of inflammation of the osteomeatal complex, osteometal complex or sinus cavity inflammation due to surgery;

rhinitis;

rhinosinusitis;

upper respiratory tract infections;

otitis media;

bronchitis;

bronchiolitis;

asthma;

tonsillitis and other chronic diseases of the tonsils and adenoids;

laryngitis;

tracheitis;

nasal and sinus polyposis;

neoplasms of the large and small airways; and

nasal, sinus, and nasopharynx tumors.

3. The method of claim 2 wherein the condition is inflammation of the osteomeatal complex.

4. The method of claim 2 wherein the condition is nasal or sinus polyposis.

5. The method of claim 1 wherein the active agent is delivered to the uncinate process.

6. The method of claim 1 wherein the active agent is delivered to the ethmoid bulla.

7. The method of claim 1 wherein the device is placed within the osteomeatal complex using a conduit having a lumen.

8. The method of claim 7 wherein the conduit is configured to pierce one or more structures of the osteomeatal complex.

9. The method of claim 1 further comprising use of a tool to aid visualization.

10. The method of claim 9 wherein the tool is an endoscope.

11. The method of claim 1 wherein the active agent is selected from the group consisting of anticholinergic agents, antihistamines, anti-infective agents, anti-inflammatory agents, antiscarring or antiproliferative agents, chemotherapeutic or antineoplastic agents, cytokines, decongestants, healing promotion agents and vitamins, hyperosmolar agents, immunomodulator or immunosuppressive agents, leukotriene modifiers, mucolytics, narcotic analgesics, small molecules, tyrosine kinase inhibitors, peptides, proteins, nucleic acids, biological macromolecules, vasoconstrictors, and combinations thereof.

12. A method for treating a condition affecting the osteomeatal complex comprising delivering to the uncinate process a device comprising a single looped fiber having therapeutically effective amount of an active agent for sustained release to treat the condition, wherein the single looped fiber device is passively fixed in place via expansive tension.