Methods and compositions for treating skin
First Claim
Patent Images
1. A method for treating intact irritated or inflamed skin by topically applying a composition that comprises:
- at least one Histamine pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of flavones, apigenins, flavonoids, luteolins, phloretins, chalcones and mixtures thereof,at least one Phospholipase A2 pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of amentoflavone, licochalcone, ellagic acid, hesperitin, polyphenol, and mixtures thereof,at least one Cyclooxygenase-2 pathway inhibitor in the form of a botanical extract selected from the group consisting of Acacia genus, Calluna genus, Rosa genus, Polyporus genus, Chamomilla genus, nettle leaf, Butcher'"'"'s broom;
hesperidin, methyl chalcone, resveratrol, HOPS beta acids, and mixtures thereof; and
at least one Vascular Endothelial Growth Factor pathway inhibitor in the form of a botanical extract selected from the group consisting of Saussurea genus, Magnolia genus, Cynara genus, Echineacea genus, Pallida genus;
sesquiterpene lactones, hypoestoxide, and mixtures thereof;
wherein the composition has an efficacy equal to or greater than a topically applied composition containing 1% hydrocortisone in ameliorating the adverse effects of skin irritation or inflammation when the composition is tested for such efficacy by applying same to a 1.5 inch square of the volar forearm and after 20 minutes 4 mg/cm2 Balsam of Peru is applied in a 1.5 cm diameter circle to the site where the composition was applied and the degree of redness is measured with a chromameter.
1 Assignment
0 Petitions
Accused Products
Abstract
A method for formulating products to normalize skin or treat irritated or inflamed skin, a method for normalizing skin or treating irritated or inflamed skin for improvement, and compositions therefor.
56 Citations
20 Claims
-
1. A method for treating intact irritated or inflamed skin by topically applying a composition that comprises:
-
at least one Histamine pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of flavones, apigenins, flavonoids, luteolins, phloretins, chalcones and mixtures thereof, at least one Phospholipase A2 pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of amentoflavone, licochalcone, ellagic acid, hesperitin, polyphenol, and mixtures thereof, at least one Cyclooxygenase-2 pathway inhibitor in the form of a botanical extract selected from the group consisting of Acacia genus, Calluna genus, Rosa genus, Polyporus genus, Chamomilla genus, nettle leaf, Butcher'"'"'s broom;
hesperidin, methyl chalcone, resveratrol, HOPS beta acids, and mixtures thereof; andat least one Vascular Endothelial Growth Factor pathway inhibitor in the form of a botanical extract selected from the group consisting of Saussurea genus, Magnolia genus, Cynara genus, Echineacea genus, Pallida genus;
sesquiterpene lactones, hypoestoxide, and mixtures thereof;wherein the composition has an efficacy equal to or greater than a topically applied composition containing 1% hydrocortisone in ameliorating the adverse effects of skin irritation or inflammation when the composition is tested for such efficacy by applying same to a 1.5 inch square of the volar forearm and after 20 minutes 4 mg/cm2 Balsam of Peru is applied in a 1.5 cm diameter circle to the site where the composition was applied and the degree of redness is measured with a chromameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. A method for treating intact irritated or inflamed skin for redness, pain or heat by topically applying to the skin a composition comprising:
-
at least one Histamine pathway inhibitor; at least one Phospholipase A2 pathway inhibitor, at least one Lipooxygenase pathway inhibitor, at least one Cyclooxygenase 2 pathway inhibitor, at least one Chemotaxis pathway inhibitor, at least one Adhesion pathway inhibitor, at least one Collagenase pathway inhibitor, at least one Elastase pathway inhibitor, at least one Phosphodiesterase A2 pathway inhibitor, at least one VEGF pathway inhibitor; and at least one Histamine receptor pathway inhibitor. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
Specification