2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections

• US 8,536,187 B2
• Filed: 07/01/2009
• Issued: 09/17/2013
• Est. Priority Date: 07/03/2008
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Sciences Inc.
• Inventors: Canales, Eda, Chong, Lee S., Clarke, Michael O' Neil Hanrahan, Lazerwith, Scott E., Lew, Willard, Liu, Qi, Mitchell, Michael L., Watkins, William J., Zhang, Jennifer R.
• Primary Examiner(s): MURRAY, JEFFREY H
• Application Number:
  US12/996,110
• Publication Number:
  US 20110123493A1
• Time in Patent Office: 1,539 Days
• Field of Search: None
• US Class Current: 514/264.11
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R₁, R₂ and R₃ are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.

Claims

1. A compound represented by the structural formula (Ia):

2. A compound according to claim 1, wherein R₂ is NHR₄.

3. A compound according to claim 2, wherein R₄ is C_3-6 cycloalkyl substituted with one or more substituents independently selected from C_1-4 alkyl optionally substituted with one or more halogens, or —

CON(R₁₃)₂.

4. A compound according claim 3, wherein R₄ is cyclopropyl.

5. A compound according to claim 3, wherein R₄ is substituted with CF₃.

6. A compound according claim 1, wherein R₃ is optionally substituted C_2-6 alkynyl.

7. A compound according claim 1, wherein R₃ is mono-substituted or disubstituted phenyl.

8. A compound according to claim 1, wherein R₃ is mono-substituted or di-substituted heteroaryl.

9. A compound according to claim 1, wherein R₂ is XR₇.

10. A compound according to claim 9, wherein X is O or NH.

11. A compound according to claim 10, wherein R₇ is C_1-6 alkyl wherein said C_1-6 alkyl is optionally substituted independently with one to six fluorine or chlorine atoms, or C_3-6 cycloalkyl, wherein said C_3-6 cycloalkyl is optionally substituted with one or more substituents independently selected from C_1-4 alkyl optionally substituted with one or more halogen or C_1-4 alkoxy optionally substituted with one or more halogen.

12. A compound according to claim 11, wherein R₇ is 2,2,2-trifluoroethyl or cyclopropyl optionally substituted with one or more C_1-4 alkyl optionally substituted with one or more fluorine atoms.

13. A compound according to claim 9, wherein R₃ is optionally substituted ethynyl wherein the substitutents of said optionally substituted ethynyl are independently selected from the group consisting of optionally substituted phenyl, optionally substituted heteroaryl, C_1-6 alkoxy, C_1-6 alkyl, and C_3-6 cycloalkyl.

14. A compound according to claim 9, wherein R₃ is an at least para-substituted phenyl group wherein the para-substituent of said phenyl group is C_1-6 alkoxy optionally substituted with 1-6 halogens.

15. A compound according to claim 9, wherein R₃ is a pyridin-3-yl or pyrimidin-5-yl group wherein the 6-position of said pyridin-3-yl or 2-position of said pyrimidiin-5-yl group is substituted with a C_2-6 alkoxy group optionally substituted with 2-5 deuteriums;

a C₁ alkoxy group substituted with 1-3 halogens;

or a C_3-7 cycloalkoxy group.

16. A compound according to claim 9, wherein R₃ is a mono-substituted or di-substituted phenyl or heteroaryl, wherein at least one substituent of said phenyl or heteroaryl is —

SO₂(C_1-3 alkyl) wherein said C_1-3 alkyl is optionally substituted with one to three halogens;

—

SO₂(C_3-6cycloalkyl) or —

SO₂(CH₂OCH₃) and the remaining substituents of said phenyl or heteroaryl are independently selected from the group consisting of H, halogen, hydroxyl, cyano, —

CON(R₁₃)₂, —

NR₁₂COR₁₀, —

NR₁₁R₁₁, —

SO₂R₉, —

NHSO₂R₉, C_3-6 cycloalkyl, phenoxy, C_1-6 alkoxy and C_1-6 alkyl wherein said C_1-6 alkyl or C_1-6 alkoxy is optionally substituted with one or more substituents selected from halogen, hydroxyl, C_1-4 alkoxy, cyano, amino, di-C_1-4 alkylamino, mono-C_1-4 alkylamino or heterocyclyl.

17. A compound according to claim 1, wherein R₁ is NH—

CH₂R₆,CH(CH₃)R₆, or NH—

CH(CH₂CH₃)R₆.

18. A compound according to claim 17, wherein R₆ is phenyl substituted with at least one substiutent that is —

NR₁₁R₁₁ or —

SO₂R₉.

19. A compound of claim 1 selected from the group consisting of:

4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

(R)-4-{1-[6-(4-fluorophenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

2-fluoro-5-{[6-(4-fluorophenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-{[6-(4-fluorophenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-benzenesulfonamide,

3-chloro-5-{[6-(4-fluorophenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-Methanesulfonyl-4-methoxy-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-methanesulfonyl-4-methylphenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-methanesulfonyl-4-methoxymethylphenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(6-amino-pyridin-3-yl)-N2-(1-methyl-2-[1,2,4]triazol-1-yl-ethyl)-N4-(1-trifluoromethyl-cyclopropyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-methyl-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(4-chloro-3-(methylsulfonyl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-fluorobenzenesulfonamide,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-chlorobenzenesulfonamide,

N-tert-butyl-3-((6-(4-chloro-3-(methylsulfonyl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-fluorobenzenesulfonamide,

N²-(3-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3,5-difluorobenzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-chloro-3-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methylbenzenesulfonamide,

3-chloro-4-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(3,4-difluorobenzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-((6-(4-(5-oxoimidazolidin-1-yl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-chloro-5-((6-(3-methoxyprop-1-ynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-((6-(4-(1-(trifluoromethyl)cyclopropylcarboxamido)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-cyano-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

1-(4-(2-(3-(methylsulfonyl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)phenyl)-3-methylimidazolidin-2-one,

4-((6-(3-(1,1-dioxo-isothiazolidin-2-yl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-ethoxypyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(2-methyl-1H-imidazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-imidazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(cyclopropylamino)pyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-fluoro-5-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

1-(4-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)phenyl)imidazolidin-2-one,

4-((6-(4-(1,1-dioxo-isothiazolidin-2-yl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(6-(cyclopropylamino)-5-fluoropyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-cyano-4-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(4-(difluoromethoxy)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(3-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(cyclopropylamino)-5-fluoropyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(2-cyclopropylethynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-fluorobenzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(cyclopropylamino)-5-fluoropyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclohexylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclohexylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

3-ethyl-4-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N²-(3-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(cyclopropylamino)pyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopentylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclobutylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N²-(3-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-aminopyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-3-isopropylbenzenesulfonamide,

4-((6-(4-methoxy-3-(trifluoromethyl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

2-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-methylbenzenesulfonamide,

3-fluoro-5-((6-(6-fluoropyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N-tert-butyl-3-fluoro-5-((6-(6-fluoropyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((R)-1-(6-(6-fluoropyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((4-(1-(trifluoromethyl)cyclopropylamino)-6-(3-(trifluoromethyl)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-methylbenzenesulfonamide,

4-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-2,5-dimethylbenzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(6-aminopyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(3-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)phenyl)methanesulfonamide,

2-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)-3-(trifluoromethyl)benzenesulfonamide,

3-chloro-5-((6-(6-fluoropyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-chloro-5-((6-(2-cyclopropylethynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(2-cyclopropylethynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

2-(6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethanesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-((6-(4-(1-(trifluoromethyl)cyclopropylaminocarbonyl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(6-fluoropyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(2-cyano-4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-((6-(2-cyano-4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

3-chloro-5-((6-(2-cyano-4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-chloro-5-((6-(4-fluoro-2-aminocarbonylphenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-((6-(4-fluoro-2-aminocarbonylphenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

(S)-N-(4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)-3-methylphenylsulfonyl)propionamide,

2-(2-(3-(methylsulfonyl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)-5-fluorobenzonitrile,

N²-(3-fluorobenzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(2-cyclopropylethynyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

N-(3-fluoro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)phenyl)methanesulfonamide,

(S)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)-3-methylbenzenesulfonamide,

(S)-N²-(1-(1H-1,2,4-triazol-1-yl)butan-2-yl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

(R)-N²-(1-(1H-1,2,4-triazol-1-yl)butan-2-yl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

1-(4-(2-(3-(methylsulfonyl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-c]pyrimidin-6-yl)phenyl)imidazolidin-2-one,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-aminopyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(trifluoromethyl)benzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(6-(cyclopropylamino)pyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-fluoro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)-3-methylbenzenesulfonamide,

5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-2-(trifluoromethyl)benzenesulfonamide,

(R)-4-(1-(6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)-2-(trifluoromethyl)benzenesulfonamide,

3-chloro-5-((6-(4-(1-(trifluoromethyl)cyclopropylcarboxamido)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-cyano-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

1-(4-(2-(3-(methylsulfonyl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)phenyl)-3-methylimidazolidin-2-one,

4-((6-(3-(1,1-dioxo-isothiazolidin-2-yl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-ethoxypyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(2-methyl-1H-imidazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-imidazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(cyclopropylamino)pyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-fluoro-5-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-fluorophenyl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

1-(4-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-6-yl)phenyl)imidazolidin-2-one,

4-((6-(4-(1,1-dioxo-isothiazolidin-2-yl)phenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(6-(cyclopropylamino)-5-fluoropyridin-3-yl)-N⁴-(1-(trifluoromethyl)cyclopropyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((4-(1-cyanocyclopropylamino)-6-(6-methoxypyridin-3-yl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

5-((4-(1-carbamoylcyclopropylamino)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)picolinamide,

N-(5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)pyridin-3-yl)methanesulfonamide,

4-((6-(4-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N-tert-butyl-4-((R)-1-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

2-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethanesulfonamide,

N²-cyclopropyl-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(2-methoxyethyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(1H-pyrazol-1-yl)benzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

N-(4-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)phenylsulfonyl)propionamide,

4-((6-(4-methyl-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((R)-1-(6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((6-(4-(methoxymethyl)-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

2-chloro-4-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N-(3-((6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)phenylsulfonyl)propionamide,

4-((6-(3-(ethylsulfonyl)-4-methoxyphenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((4-(1,1,1,3,3,3-hexafluoropropan-2-ylamino)-6-(4-methoxy-3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((R)-1-(6-(4-methyl-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

6-(4-methoxy-3-(methylsulfonyl)phenyl)-N²-(2-methoxyethyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((R)-1-(6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)propyl)benzenesulfonamide,

4-((R)-1-(6-(4-chloro-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((R)-1-(6-(5-(methylsulfonyl)pyridin-3-yl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((6-(3-(cyclopropylsulfonyl)-4-methoxyphenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)propane-1,2-diol,

2-methyl-1-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)propan-2-ol,

(2R)-2-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)propanoic acid,

N²-(3,4-difluorobenzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

2-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethanol,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(4-methoxy-3-(trifluoromethylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

6-(4-methoxy-3-(methylsulfonyl)phenyl)-N²-(pyridin-3-ylmethyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-pyrazol-1-yl)benzyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((S)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-methoxy-3-(trifluoromethylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

2-(6-(4-methoxy-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethanesulfonamide,

N²-(3-(methylsulfonyl)benzyl)-6-(4-methyl-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-fluoro-4-methylbenzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-N²-(pyridin-3-ylmethyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-methyl-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(1-(3,5-difluorophenyl)ethyl)-6-(4-methoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(3-(ethylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(3-(ethylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-ethoxy-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)methyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((R)-1-(4-cyclopropoxy-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-((S)-1,1,1-trifluoropropan-2-yl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclopropoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-ethoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclopropoxy-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N²-(4-(1H-imidazol-1-yl)benzyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-((1S,3r,5R)-bicyclo[3.1.0]hexan-3-yloxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-((1S,3r,5R)-bicyclo[3.1.0]hexan-3-yloxy)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-N⁴-(2-chloro-2,2-difluoroethyl)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-tert-butoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-isopropoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-4-isopropoxypyrido[3,2-d]pyrimidin-2-amine,

4-((R)-1-(4-cyclobutoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclobutoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclobutoxy-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzyl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N²-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(pyrimidin-5-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(thiazol-5-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-imidazol-5-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

4-((4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)phenol,

methyl (R)-1-((S)-3-(6-(4-(difluoromethoxy)-3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate,

methyl (R)-3-methyl-1-((S)-3-(6-(3-(methylsulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)pyrrolidin-1-yl)-1-oxobutan-2-ylcarbamate,

N-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N²-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzyl)-6-(3-(methylsulfonyl)phenyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(2-methylpyridin-3-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(thiophen-3-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(5-ethyl-1,3,4-thiadiazol-2-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1-methyl-1H-imidazol-5-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1-methyl-1H-imidazol-4-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(furan-3-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(6-methylpyridin-2-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(pyrimidin-2-yl)benzyl)-4-(1-methylcyclopropoxy)-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzyl)-4-cyclopropoxy-6-(3-(methylsulfonyl)phenyl)pyrido[3,2-d]pyrimidin-2-amine,

4-((6-(4-methoxy-3-(aminosulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(3-(aminocarbonyl)l-4-methoxyphenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(4-methoxy-3-(morpholinosulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

4-((6-(4-methoxy-3-(trifluoromethyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-ethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(3-(methylsulfonyl)benzyl)-6-(6-ethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-((4-(2,2,2-trifluoroethylamino)-6-(4-(trifluoromethoxy)phenyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(6-ethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-((6-(6-ethoxypyridin-3-yl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

5-(2-(3,4-difluorobenzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzenesulfonamide,

5-(2-(1-(3,5-difluorophenyl)ethylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzenesulfonamide,

5-(2-(4-(1H-pyrazol-1-yl)benzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzenesulfonamide,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzenesulfonamide,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzonitrile,

5-(2-(4-cyclopropylbut-3-yn-2-ylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-methoxybenzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-isopropoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(6-isopropoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-pyrazol-1-yl)benzyl)-6-(6-isopropoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

4-((6-(6-(difluoromethoxy)pyridin-3-yl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-(difluoromethoxy)pyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclopropoxy-6-(6-cyclopropoxypyridin-3-yl)pyrido[3,2-d]pyrimidin-2-amine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclobutoxypyridin-3-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclobutoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclobutoxypyridin-3-yl)-4-cyclopropoxypyrido[3,2-d]pyrimidin-2-amine,

4-((R)-1-(4-cyclobutoxy-6-(6-cyclopropoxypyridin-3-yl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(2-cyclopropoxypyrimidin-5-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-4-cyclopropoxy-6-(2-cyclopropoxypyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine,

N²-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethyl)-6-(6-pentadeuteroethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-pentadeuteroethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(2-cyclopropoxypyrimidin-5-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N²-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(6-cyclopropoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-ethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-pentadeuteroethoxypyridin-3-yl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((R)-1-(6-(4-ethoxy-3-(aminosulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

5-(2-(4-(1H-imidazol-1-yl)benzylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

5-(2-(4-(1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

4-((R)-1-(6-(4-ethoxy-3-(aminosulfonyl)phenyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

5-(2-((R)-1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethylamino)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

methyl (R)-1-((S)-3-(6-(4-ethoxy-3-(aminosulfonyl)phenyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-4-cyclopropylpyrido[3,2-d]pyrimidin-2-amine,

N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzyl)-6-(6-cyclopropoxypyridin-3-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

5-(2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzylamino)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

N-((R)-1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(6-cyclopropoxypyridin-3-yl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-amine,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-N⁴-(2-chloro-2,2-difluoroethyl)-6-(6-cyclopropoxypyridin-3-yl)pyrido[3,2-d]pyrimidine-2,4-diamine,

5-(2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)benzylamino)-4-cyclopropoxypyrido[3,2-d]pyrimidin-6-yl)-2-ethoxybenzenesulfonamide,

4-((4-ethoxy-6-(1-(4-fluorophenyl)vinyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-N-tert-butyl-4-(1-(6-(2-cyclopropylethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(3-hydroxy-3-methylbut-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(3-methoxyprop-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

3-((6-(2-cyclopropylethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

4-((6-(2-cyclopropylethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-chloro-5-((6-(2-cyclopropylethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-N²-(1-(1H-1,2,4-triazol-1-yl)propan-2-yl)-6-(2-cyclopropylethynyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

3-((6-(3-methoxyprop-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide,

4-((6-(3-methoxyprop-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-ethynyl-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(3,3-dimethylbut-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((4-cyclopropoxy-6-(2-cyclopropylethynyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(2-cyclopropylethynyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

4-((6-ethynyl-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(S)-4-((6-ethynyl-4-(1,1,1-trifluoropropan-2-ylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(S)-4-((6-(2-cyclopropylethynyl)-4-(1,1,1-trifluoropropan-2-ylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(S)-N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-ethynyl-N⁴-(1,1,1-trifluoropropan-2-yl)pyrido[3,2-d]pyrimidine-2,4-diamine,

(S)-N²-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(2-cyclopropylethynyl)-N⁴-(1,1,1-trifluoropropan-2-yl)pyrido[3,2-d]pyrimidine-2,4-diamine,

N²-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)methyl)-6-(2-cyclopropylethynyl)-N⁴-(2,2,2-trifluoroethyl)pyrido[3,2-d]pyrimidine-2,4-diamine,

(R)-4-(1-(4-cyclopropoxy-6-ethynylpyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-ethynyl-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-(thiazol-5-yl)ethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(prop-1-ynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((R)-1-(4-((1S,3r, 5R)-bicyclo[3.1.0]hexan-3-yloxy)-6-(2-cyclopropylethynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((4-cyclopropoxy-6-ethynylpyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

3-chloro-5-((6-(2-cyclopropylethynyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(4-(1-methylcyclopropoxy)-6-(prop-1-ynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

3-chloro-5-((4-(1-methylcyclopropoxy)-6-vinylpyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-isopropoxypyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(4-cyclobutoxy-6-(2-cyclopropylethynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-ethynyl-4-isopropoxypyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(4-cyclobutoxy-6-ethynylpyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

N-(4-(1H-1,2,4-triazol-1-yl)benzyl)-6-(2-cyclopropylethynyl)-4-isopropoxypyrido[3,2-d]pyrimidin-2-amine,

(R)-4-(1-(4-cyclopropoxy-6-(prop-1-ynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(4-cyclobutoxy-6-(prop-1-ynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

3-chloro-5-((4-(1-methylcyclopropoxy)-6-(prop-1-ynyl)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide,

(R)-4-(1-(4-(2,2,2-trifluoroethylamino)-6-vinylpyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((R)-1-(4-((1S,3r,5R)-bicyclo[3.1.0]hexan-3-yloxy)-6-(prop-1-ynyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

4-((R)-1-(4-((1S,3r,5R)-bicyclo[3.1.0]hexan-3-yloxy)-6-ethynylpyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-methoxypyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-cyclopropylethynyl)-4-ethoxypyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-(1H-imidazol-4-yl)ethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-(1H-imidazol-4-yl)ethynyl)-4-(1-methylcyclopropoxy)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide,

(R)-4-(1-(6-(2-(1H-imidazol-2-yl)ethynyl)-4-(2,2,2-trifluoroethylamino)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide, and

4-((R)-1-(6-(2-(1H-imidazol-4-yl)ethynyl)-4-((1S,3r,5R)-bicyclo[3.1.0]hexan-3-yloxy)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide;

or

a pharmaceutically acceptable salt thereof.

20. A compound of claim 1 selected from the group consisting of:

4-{1-[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-3-methyl-benzenesulfonamide,

4-{1-[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-3-trifluoromethyl-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-methyl-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-trifluoromethyl-benzenesulfonamide,

2-Chloro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

2-Chloro-4-{1-[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

2-Fluoro-4-{1-[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide,

4-{1-[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide,

N-(3-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide,

N-(2-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide,

N-(5-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-phenyl)-methanesulfonamide,

N-(2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide,

N-(3-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide,

N-(3-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide,

N-(3-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-phenyl)-methanesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclobutylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopentylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclohexylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(6-Cyclopropylamino-pyridin-3-yl)-N2-(1-methyl-2-[1,2,4]triazol-1-yl-ethyl)-N4-(1-trifluoromethyl-cyclopropyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

4-{[6-(4-Fluoro-3-methanesulfonyl-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-Methanesulfonyl-4-methyl-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-Methanesulfonyl-4-methoxy-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(4-Chloro-3-methanesulfonyl-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-Cyclopropanesulfonyl-4-methoxy-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(3-Methanesulfonyl-4-methoxy-phenyl)-N2-[1-(4-[1,2,4]triazol-1-yl-phenyl)-ethyl]-N4-(1-trifluoromethyl-cyclopropyl)-pyrido[3,2-d]pyrimidine-2,4-diamine, and

6-(3-Methanesulfonyl-4-methoxy-phenyl)-N2-[1-(4-[1,2,4]triazol-1-yl-phenyl)-ethyl]-N4-(1-trifluoromethyl-cyclopropyl)-pyrido[3,2-d]pyrimidine-2,4-diamine;

or

a pharmaceutically acceptable salt thereof.

21. A compound of claim 1 selected from the group consisting of:

3-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-5-trifluoromethyl-benzenesulfonamide,

2-fluoro-5-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide,

4-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide,

3-fluoro-5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-cyano-5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-chloro-5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-[1,2,4]triazol-1-yl-benzenesulfonamide,

2-fluoro-4-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

4-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-2-methyl-propyl}-benzenesulfonamide,

4-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-butyl}-benzenesulfonamide,

2-chloro-4-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

2-chloro-5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(4-fluorophenyl)-N2-(3-fluoro-5-[1,2,4]triazol-1-yl-benzyl)-N4-(2,2,2-trifluoroethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

2-chloro-5-{[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

6-(4-fluorophenyl)-N2-[1-(3-fluoro-5-[1,2,4]triazol-1-yl-phenyl)-ethyl]-N4-(2,2,2-trifluoroethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

3-chloro-5-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

3-fluoro-5-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

3-{1-[6-(4-fluorophenyl)-4-(2,2,2-trifluoroethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

(R)-4-{1-[6-(4-fluorophenyl)-4-cyclopropoxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

(R)-4-{1-[6-(4-fluorophenyl)-4-cyclobutoxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

(R)-4-{[6-(4-fluorophenyl)-4-cyclopentoxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

(R)-4-{[6-(4-fluorophenyl)-4-cyclohexyloxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

(R)-4-{[6-(4-fluorophenyl)-4-cycloheptyloxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide, and

(R)-4-{1-[6-(4-fluorophenyl)-4-cyclooctyloxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide;

or

a pharmaceutically acceptable salt thereof.

22. A compound of claim 1 selected from the group consisting of:

6-(4-Fluoro-phenyl)-N2-(3-[1,2,4]triazol-1-yl-benzyl)-N4-(2,2,2-trifluoro-ethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

6-(4-Fluoro-phenyl)-N2-(3-pyrazol-1-yl-benzyl)-N4-(2,2,2-trifluoro-ethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-methyl-benzenesulfonamide,

2-Chloro-4-{[6-(4-fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

5-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-methoxy-benzenesulfonamide,

2-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

3-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide,

4-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-3-methyl-benzenesulfonamide,

(R)-2-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-propyl}-benzenesulfonamide,

(R)-4-{[6-(4-Fluoro-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-propyl}-benzenesulfonamide,

(R)-4-{1-[6-(4-Fluoro-phenyl)-4-cyclopropoxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide,

3-{[6-(3-Methanesulfonyl-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

4-{[6-(3-Methanesulfonyl-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(3-Methanesulfonyl-phenyl)-N2-(3-[1,2,4]triazol-1-yl-benzyl)-N4-(2,2,2-trifluoro-ethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

4-{[6-(3-Methanesulfonyl-4-methoxy-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide,

6-(3-Methanesulfonyl-phenyl)-N2-[1-(4-[1,2,4]triazol-1-yl-phenyl)-ethyl]-N4-(2,2,2-trifluoro-ethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

6-(3-Methanesulfonyl-phenyl)-N2-(3-[1,2,4]triazol-1-yl-benzyl)-N4-(2,2,2-trifluoro-ethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine,

4-{[6-(4-Fluoro-3-methanesulfonyl-phenyl)-4-(2,2,2-trifluoro-ethylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide, and

4-{[4-Cyclopropoxy-6-(3-methanesulfonyl-phenyl)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide;

or

a pharmaceutically acceptable salt thereof.

23. A pharmaceutical composition comprising one or more pharmaceutically acceptable carriers and the pyrido(3,2-d)pyrimidine derivative according to- claim 1, or a pharmaceutical acceptable addition salt thereof and optionally one or more antiviral agents.