Epothilone derivatives

• US 8,536,327 B2
• Filed: 06/15/2007
• Issued: 09/17/2013
• Est. Priority Date: 07/08/1997
• Status: Expired due to Fees

• Current Assignee: R-pharm us operating llc
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Vite, Gregory D., Kim, Soong-Hoon, Borzilleri, Robert M., Johnson, James A.
• Primary Examiner(s): KOSACK, JOSEPH R
• Application Number:
  US11/763,636
• Publication Number:
  US 20070255055A1
• Time in Patent Office: 2,286 Days
• Field of Search: 540/455
• US Class Current: 540/455
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C07D 417/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 491/04 Ortho-condensed systems
• CPC Class Codes: C07D 491/044 with only one oxygen atom as ring hetero atom in the oxygen-containing ring
• CPC Class Codes: C07D 493/04 Ortho-condensed systems

Abstract

The present invention relates to compounds of the formula

where the variables are as defined in the disclosure.

Claims

1. A compound having the formula V,

2. A compound according to claim 1 wherein G is bicycloheteroaryl selected from benzothiazolyl, benzoxazolyl, benzothienyl, quinuclidinyl, quinolinyl, quinolinyl-N-oxide, tetrahydroisoquinolinyl, isoquinolinyl, benzimidazolyl, benzopyranyl, indolizinyl, benzofuryl, chromonyl, coumarinyl, cinnolinyl, quinoxalinyl, indazolyl, pyrrolopyridyl, furo[2,3-c]pyridinyl, furo[3,1-13]pyridinyl, furo[2,3-b]pyridinyl, dihydroisoindolyl, 3,4-dihydro-4-oxo-quinazolinyl, benzisothiazolyl, benzisoxazolyl, benzodiazinyl, benzofurazanyl, benzothiopyranyl, benzotriazolyl, benzpyrazolyl, dihydrobenzofuryl, dihydrobenzothienyl, dihydrobenzothiopyranyl, dihydrobenzothiopyranyl sulfone, dihydrobenzopyranyl, indolinyl, isochromanyl, isoindolinyl, naphthyridinyl, phthalazinyl, piperonyl, purinyl, pyridopyridyl, quinazolinyl, tetrahydroquinolinyl, thienofuryl, thienopyridyl, and thienothienyl.

3. A compound according to claim 2 wherein G is benzothiazolyl.