Real-time digital image processing architecture

• US 8,537,237 B2
• Filed: 12/18/2008
• Issued: 09/17/2013
• Est. Priority Date: 03/12/2008
• Status: Active Grant

• Current Assignee: Siemens Healthcare Nederland B.V. (Siemens AG)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Kahlman, Josephus Arnoldus Henricus Maria
• Primary Examiner(s): MOE, AUNG SOE
• Application Number:
  US12/919,519
• Publication Number:
  US 20110007183A1
• Time in Patent Office: 1,734 Days
• Field of Search: 348/222.1, 348/229.1, 348/221.1, 348/256, 348/362, 348/364, 382/128, 382/129, 382/130, 382/133, 382/134, 382/132, 356/39, 356/445, 377/10, 702/19
• US Class Current: 348/222.1
• CPC Class Codes: G06T 2207/10016 Video; Image sequence
• CPC Class Codes: G06T 2207/20182 Noise reduction or smoothing in the temporal domain; Spatio-temporal filtering
• CPC Class Codes: G06T 2207/30072 Microarray; Biochip, DNA array; Well plate
• CPC Class Codes: G06T 5/70 Denoising; Smoothing

Abstract

A digital image processing device processes digital images provided by a camera of biosensor reader. The device includes a pixel processing unit for evaluating a stream of image values with respect to a given set of processing spots in the image area, thus determining characteristic parameters like the integral of pixel values in the processing spots. The pixel processing unit communicates with a higher-level digital control unit that sets the processing spots to be evaluated and that reads out and post-processes the results of the pixel processing unit.

Claims

1. A digital image processing device for real-time evaluation of a sequence of image frames provided by a camera comprising:

a memory;

a digital pixel processing unit configured to determine characteristic parameters of a set of processing spots in an image area from a stream of image values, and store the characteristic parameters in the memory; and

a digital control unit in communication with the pixel processing unit, wherein the digital control unit is configured to set the set of processing spots for use by the digital pixel processing unit for determining the characteristic parameters of the set of processing spots, and wherein the digital control unit is further configured to read out from the memory and post-process the characteristic parameters determined by the digital pixel processing unit.

2. The image processing device according to claim 1,

wherein the processing spots relate to a rectangular image region.

3. The image processing device according to claim 1,

wherein the set of processing spots comprises a single processing spot only, a plurality of processing spots from an image stripe (S_j), and/or a plurality of processing spots from the whole image area.

4. The image processing device according to claim 1,

wherein the characteristic parameters comprise an integral of a function of deviations of the image values from a reference value.

5. The image processing device according to claim 4,

wherein the digital control unit is further configured to determine a changing rate of the reference value based on characteristic parameters of previous frames.

6. The image processing device according to claim 1,

wherein the memory comprises at least one shadow register for storing data to be exchanged between the pixel processing unit and the digital control unit.

7. The image processing device according to claim 1,

wherein the digital control unit is further configured to set the set of processing spots once before the evaluation of a sequence of frames, at a beginning of each frame, at a beginning of a sub-frame, and/or on demand of the pixel processing unit.

8. The image processing device according to claim 1,

wherein the digital control unit is further configured to iteratively adapt at least one processing spot to an image position of a marker.

9. The image processing device according to claim 1,

further comprising a focusing module configured to change a focus of the camera based on the characteristic parameters including based on a function of a deviation of all image values from a reference value in a processing spot.

10. The image processing device according to claim 9, wherein the focusing module is further configured to obtain a desired focus based on a maximum value of the deviation.

11. The image processing device according to claim 1,

further comprising a status indicator for signaling detection of an exceptional state in at least one image frame including detection of a deteriorated optical quality.

12. The image processing device according to claim 1,

wherein the post-processing of the digital control unit is further configured to perform temporal filtering the characteristic parameters that have been obtained for a selected subset of the image frames by the digital pixel processing unit.

13. The image processing device according to claim 12,

wherein the filtered characteristic parameters subtracted from corresponding characteristic parameters obtained for image frames that do not belong to the selected subset.

14. The image processing device according to claim 1,

further comprising a controllable illumination unit configured to selectively set exposure conditions for different image frames.

15. The image processing device according to claim 1, wherein the digital control unit is further configured to set the set of processing spots in response to a demand of the pixel processing unit.

16. A method for evaluating a sequence image frames(I_t) provided by a camera comprising the acts of:

determining by a digital control unit a set processing spots in an image are from a stream of image value;

determining by a pixel processing unit at least one characteristic parameter of the set of processing spots set by the digital control unit;

storing the at least one characteristic parameter in a memory;

post-processing the at least one characteristic parameter by the digital control unit;

exchanging data between the digital control unit and the pixel processing after the pixel processing unit has completed processing of a current set of processing spots for one frame.

17. A non-transitory computer readable medium comprising computer instructions which, when executed by a processor, configure the processor to perform the acts of:

determining by a digital control unit a set of processing spots in an image area from a stream of image values;

determining by a pixel processing unit at least one characteristic parameter of the set of processing spots set by the digital control unit;

storing the at least one characteristic parameter in a memory;

post-processing the at least one characteristic parameter by the digital control unit;

exchanging data between the digital control unit and the pixel processing unit after the pixel processing unit has completed processing of a current set of processing spots for one frame.