Methods and systems for integrated health systems
First Claim
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1. A method of performing a course of medical action for a medical condition of a subject comprising:
- a) obtaining a first series of PSA values from a subject;
b) performing a first dynamic analysis using a computer system, comprising;
i) fitting said first series of PSA values to form a first fitted trend;
ii) estimating a first characteristic of said first fitted trend, wherein said first characteristic is a first PSA velocity defined as a rate of change in trend PSA;
iii) calculating one or more probabilities of the occurrence of one or more medical conditions of said subject using said first characteristic, wherein said one or more medical conditions comprises a prostate medical condition selected from the group consisting of the following;
prostatitis due to inflammation prostatitis due to infection prostate cancer, benign prostate hyperplasia, and no prostate disease;
c) determining if the results of said first dynamic analysis have reached a first threshold for medical action, wherein said threshold corresponds to a probability that the subject has a medical condition, wherein the probability is based on analysis of PSA velocity population data; and
d) performing a first course of medical action for a first medical condition if said results of said first dynamic analysis reaches said threshold, wherein said first course of medical action is treatment with antibiotics and/or anti-inflammatory medication;
measurement of prostate volume;
continued PSA tests;
a free PSA test;
a proPSA test;
a biopsy, medical imaging;
or medical treatment for prostate cancer.
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Abstract
Methods, business methods, and systems are provided herein for integrated healthcare. As the amount of medical information increases rapidly, including information from multiple biomarkers, analysis and management of that information becomes more and more important to extract meaningful conclusions from the information. Statistical and computational methods are described herein that have been created for the methods and systems for integrated healthcare. For example, a computer system is described extracts significance over time of PSA and fPSA biomarker tests for prostate health.
42 Citations
50 Claims
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1. A method of performing a course of medical action for a medical condition of a subject comprising:
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a) obtaining a first series of PSA values from a subject; b) performing a first dynamic analysis using a computer system, comprising; i) fitting said first series of PSA values to form a first fitted trend; ii) estimating a first characteristic of said first fitted trend, wherein said first characteristic is a first PSA velocity defined as a rate of change in trend PSA;
iii) calculating one or more probabilities of the occurrence of one or more medical conditions of said subject using said first characteristic, wherein said one or more medical conditions comprises a prostate medical condition selected from the group consisting of the following;
prostatitis due to inflammation prostatitis due to infection prostate cancer, benign prostate hyperplasia, and no prostate disease;c) determining if the results of said first dynamic analysis have reached a first threshold for medical action, wherein said threshold corresponds to a probability that the subject has a medical condition, wherein the probability is based on analysis of PSA velocity population data; and d) performing a first course of medical action for a first medical condition if said results of said first dynamic analysis reaches said threshold, wherein said first course of medical action is treatment with antibiotics and/or anti-inflammatory medication;
measurement of prostate volume;
continued PSA tests;
a free PSA test;
a proPSA test;
a biopsy, medical imaging;
or medical treatment for prostate cancer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method comprising:
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a. receiving a series of PSA values of a subject; b. performing a dynamic analysis using a computer system, comprising; i) fitting said series of PSA values to form a fitted trend; ii) estimating a characteristic of said fitted trend, wherein said characteristic is a PSA velocity defined as a rate of change in trend PSA;
iii) calculating one or more probabilities of the occurrence of one or more medical conditions of said subject using said first characteristic, wherein said one or more medical conditions comprises a prostate medical condition selected from the group consisting of the following;
prostatitis due to inflammation, prostatitis due to infection, prostate cancer, benign prostate hyperplasia, and no prostate disease;c. determining if the results of said dynamic analysis have reached a first threshold for medical action for a medical condition, wherein said threshold corresponds to a probability that the subject has a medical condition, wherein the probability is based on analysis of PSA velocity population data; and d. delivering the results of said determining step to a user for use in selecting a course of medical action, wherein said course of medical action is treatment with antibiotics and/or anti-inflammatory medication;
measurement of prostate volume;
continued PSA tests;
a free PSA test;
a proPSA test;
a biopsy, medical imaging;
or medical treatment for prostate cancer. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification