3-D quantitative-imaging ultrasonic method for bone inspections and device for its implementation

• US 8,540,638 B2
• Filed: 01/17/2011
• Issued: 09/24/2013
• Est. Priority Date: 10/24/2006
• Status: Active Grant

• Current Assignee: Alla Gourevitch
• Original Assignee: Alla Gourevitch
• Inventors: Gourevitch, Alla
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): Selkin, Saurel J
• Application Number:
  US13/007,795
• Publication Number:
  US 20110112404A1
• Time in Patent Office: 981 Days
• Field of Search: None
• US Class Current: 600/447
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties

Abstract

The invention is a differential 3D Quantitative-Imaging Ultrasonic Tomography method for inspecting a layered system that is comprised of a heterogeneous object embedded in a volume of space that comprises layers having an acoustic impedance gradient between the layers providing non-linear beams travels. A transducer grid is attached to the surface of the layered system in a unilateral manner. By sequentially changing the distance between transmitter and receiver the fastest travel times of the ultrasonic oscillations are measured. A differential approach provides from the data the longitudinal wave velocities values for each elementary volume that make up an inspected volume. These values are used to construct two and three-dimensional maps of the longitudinal wave velocity values distribution in the inspected volume and the porosity values distribution in the heterogeneous object. By applying statistical treatment to the obtained data the longitudinal wave velocity in the inspected material matrix part is estimated.

Claims

1. A differential method of 3D Quantitative-Imaging Ultrasonic Tomography for inspecting a layered system comprised of a heterogeneous object embedded in a volume of space that comprises layers having an acoustic impedance gradient between said layers, wherein said acoustic impedance gradient causes non-linear elastic wave propagation of ultrasonic oscillations through said volume of space, said method comprising:

a) providing two or more transducers arranged in a line or as a two-dimensional array on one side of the layered system and in acoustic contact with the upper layer of said layered system, said transducers capable of being activated to either transmit or to receive said ultrasonic oscillations;

b) sequentially activating one of said transducers as a transmitter and others of said transducers as receivers of said ultrasonic oscillations to measure the fastest travel times for sequential transmitter/receiver pairs with sequentially changing distances between transmitter and receiver;

c) virtually dividing said volume of space into elementary volumes;

d) using a differential approach to determine values of the longitudinal wave velocity for each of said elementary volume; and

e) applying an ultrasonic computer tomography approach to construct two-dimensional and three-dimensional maps of the distributions of said longitudinal wave velocity values in said volume of space.

2. The method of claim 1 further comprising the steps of:

f) determining a correct magnitude of frequency of the ultrasonic oscillations to be used with the transducers and the arrangement of the transducers for inspection in a specific application;

g) activating a first transducer to transmit ultrasonic oscillations in the direction of an object being observed and activating the remaining transducers to receive elastic waves that have traveled through the observed layered system;

h) measuring the fastest time of travel between each transmitter-receiver pair and storing said travel times for later use;

i) repeating the measurements sequentially by changing the distance between transmitter and receivers by a fixed distance equal to distance between transducers each time;

j) repeating measurements of steps g), h), and i) in the reciprocal direction;

k) moving the line of transducers parallel to the original line or activating a second line of transducers in a two dimensional grid of transducers and repeating the measurements of steps g), h), i), and j) in the direct and reciprocal directions until data is obtained from each line in the transducer grid;

l) dividing virtually the volume of space containing the layered system into elementary volumes situated in columns and rows, thereby enabling use of a differential approach to processing the data obtained from each line in the transducer grid;

m) determining from the obtained data the values of changes in longitudinal wave travel time in each of said elementary volumes relative to the elementary volume located above it in the column from average values of the longitudinal wave travel times for neighboring routes in direct and reciprocal directions said determination comprising the steps of;

i) choosing two pairs of transducers located at two neighboring points equidistant from an axis of a column of elementary volumes;

ii) summing the values of the travel time for ultrasonic oscillations between the transducers of each of said pairs that are furthest from said axis and the travel time for ultrasonic oscillations between the transducers of each of said pairs that are closest to said axis;

iii) subtracting from the sum obtained in step ii the travel times for ultrasonic oscillations between the transducer of the pair of transducers located on a first side of said axis that is closest to said axis and the transducer of said pair of transducers that is located on the second side of said axis that is furthest from said axis;

iv) subtracting from the sum obtained in step iii the travel times for ultrasonic oscillations between the transducer of the pair of transducers located on a first side of said axis that is furthest from said axis and the transducer of said pair of transducers that is located on the second side of said axis that is closest to said axis;

v) repeating steps i to iv using different pairs of transducers for each of the elementary volumes in said column; and

vi) repeating steps i to v for each column of elementary volumes in said volume of space containing the layered system;

n) determining the values of longitudinal wave travel times for each elementary volume in each vertical column of elementary volumes by using the known or previously measured value of the longitudinal wave travel time in the first elementary volume from the surface and by successively adding said values of the changes of the longitudinal wave travel times for the elementary volumes below said first one in said column;

o) estimating the lengths of travel of the longitudinal wave through each of said elementary volumes;

p) determining the longitudinal wave velocity values in each of said elementary volumes by dividing said estimated lengths of travel of the longitudinal wave through each of said elementary volumes by said values of longitudinal wave travel times for each elementary volume in each vertical column of elementary volumes;

q) building pixel-by-pixel images of two dimensional horizontal or vertical sections from the longitudinal wave velocity values in each of said elementary volumes; and

r) combining said two dimensional images along a third axis with a constant step to build three dimensional images showing said longitudinal wave velocity values in said volume of space.

3. The method of claim 2, wherein at least some of the steps are carried out in a different order.

4. The method of claim 2, wherein determining the correct magnitude of the frequency of the ultrasonic oscillations to be used with the transducers and the arrangement of the transducers for the inspection in a specific application are determined using the following criteria:

a) the frequency is chosen such that the length of the applied oscillations are comparable to the dimensions of the inspected heterogeneous object; and

b) the distance between the first transmitting transducer and the last receiving transducer in the line must be greater than the dimensions of said inspected heterogeneous object.

5. The method of claim 2, wherein the ultrasonic oscillations are transmitted in the direction of an object being observed at an angle of no more than ninety degrees.

6. The method of claim 2, wherein the minimum distance between a transmitting transducer and a receiving transducer is two to three wavelengths of the applied oscillations.

7. The method of claim 2, wherein the length of travel of the longitudinal wave in each elementary volume is approximated by assuming that the longitudinal waves travel the same distance in each of the elementary volumes beneath the elementary volumes of the first layer of layered system;

wherein said distance is half the circumference of a circle having radius b, where b is the distance between adjoining transducers; and

by assuming that the wave travels in straight lines through the elementary volumes of the first layer, therefore the length of travel time in the first layer is 2b/sin α

where α

is the incident angle of the oscillations on the first layer.

8. The method of claim 2 wherein the acoustic properties of the uppermost elementary volumes are known or can be calculated.

9. The method of claim 2 wherein the acoustic properties of the uppermost elementary volumes are known in one of the following ways:

a) by implementing the first layer of the system as an additional plate or pillow having known acoustic properties; and

b) immersing the system in a container with liquid having known acoustic properties.

10. The method of claim 9, wherein analyzing the obtained maps by observing decreases in the values of the elastic wave velocities and increases in porosity values that are shown in different areas of said images reveals defective areas in the inspected object.

11. The method of claim 10, wherein the layered system is a human or animal body including bone material and analysis of the obtained images reveals defective areas that are problematical zones with fracture risk, estimates of the magnitude of the risk of fracture and reveal the location of the risk by calculating the ratio of relative changes of the longitudinal wave velocity values for said defective area divided by the longitudinal wave velocity in the material matrix of the object.

12. The method of claim 9, wherein analysis of the obtained maps is carried out to provide information about internal organs of an individual and to reveal changes in the properties of said organs.

13. The method of claim 2, wherein a combination of signals from eight beams transmitted in the direct and reciprocal directions is employed to determine the properties of a specific elementary volume in the observed object.

14. The method of claim 2, wherein a combination of signals from four beams transmitted in the direct direction or four beams transmitted in the reciprocal direction is employed to determine the properties of a specific elementary volume in the observed object.

15. The method of claim 2, further comprising the steps of:

i) applying statistical treatment to the longitudinal wave velocity values obtained in step p) to determine the maximum value of the longitudinal wave velocity;

ii) identifying a matrix mineral part of an observed object, wherein said matrix mineral part of the object corresponds to elementary volumes that have said maximum value of longitudinal wave velocity;

iii) determining the values of porosity for each elementary volume of an observed volume by use of the modified Wyllie relationship for objects wherein the porous space is filled with liquid;

iv) building pixel-by-pixel images of two dimensional horizontal or vertical sections from said values of porosity for each elementary volume; and

v) combining said two dimensional images along a third axis with a constant step to build three dimensional images showing the porosity values in said observed volume.

16. The method of claim 2, wherein the layered system is at least a part of a human or animal body wherein the layers comprise skin, fat, periosteum, cartilage, and muscle and bones are considered as localized heterogeneous bodies embedded in said layered system.

17. The method of claim 2, wherein the elementary volumes are cubes having sides equal in length to the distance between two adjacent lines on the 2D planar grid or distance between transducers.

18. The method of claim 1, wherein at least one of the layers of the layered system is an artificial layer that is applied to create a layered system having a gradient of acoustic impedance that allows said differential method to be carried out.

19. The method of claim 1, wherein inspecting a layered system comprises inspecting homogeneous material accommodated in said layered system, which is characterized by an acoustic impedance gradient.