Probablistic pharmacokinetic and pharmacodynamic modeling
First Claim
Patent Images
1. A system comprising:
- a processor; and
at least one memory, the processor and the at least one memory configured to provide a response determinator to;
receive therapeutic and wellness data;
determine, based on the received therapeutic and wellness data, a response representing a reaction to a substance integrated with an ingestible event marker; and
provide the determined response; and
wherein the response determinator determines the response as a response matrix, H, according to the following equation;
H=(ATA)−
1ATY, wherein A represents one or more times that a dose of the substance is ingested, AT represents a transpose of matrix A, (AT A)−
1 represents an inverse of a matrix multiplication of matrix A and matrix AT, and Y represents a matrix of observations including the therapeutic and wellness data.
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Abstract
The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.
728 Citations
13 Claims
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1. A system comprising:
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a processor; and at least one memory, the processor and the at least one memory configured to provide a response determinator to; receive therapeutic and wellness data; determine, based on the received therapeutic and wellness data, a response representing a reaction to a substance integrated with an ingestible event marker; and
provide the determined response; andwherein the response determinator determines the response as a response matrix, H, according to the following equation;
H=(ATA)−
1ATY,wherein A represents one or more times that a dose of the substance is ingested, AT represents a transpose of matrix A, (AT A)−
1 represents an inverse of a matrix multiplication of matrix A and matrix AT, and Y represents a matrix of observations including the therapeutic and wellness data. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A system comprising:
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a processor; and at least one memory, the processor and the at least one memory configured to provide a therapy controller to;
receive a response representing a reaction to a substance integrated with an ingestible event marker;receive therapeutic and wellness data; and control, based on the received response and the received therapeutic and wellness data, at least one of a dose of the substance and a time of the dose of the substance; wherein the response is determined as a response matrix, H, according to the following equation;
H=(ATA)−
1ATY,wherein A represents one or more times that a dose of the substance is ingested, AT represents a transpose of matrix A, (ATA)−
1 represents an inverse of a matrix multiplication of matrix A and matrix AT, and Y represents a matrix of observations including the therapeutic and wellness data.- View Dependent Claims (8, 9, 10, 11, 12, 13)
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Specification