Microneedle patch applicator

• US 8,540,672 B2
• Filed: 12/20/2011
• Issued: 09/24/2013
• Est. Priority Date: 12/22/2010
• Status: Expired due to Fees

• Current Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: McAllister, Devin V.
• Primary Examiner(s): FLICK, JASON E
• Application Number:
  US13/332,065
• Publication Number:
  US 20120184906A1
• Time in Patent Office: 644 Days
• Field of Search: 604/136
• US Class Current: 604/136
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 50/30 Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for wound clamps A61B17/10; for ligaturing clips A61B17/122; packages or dispensers for surgical gloves or finger-stalls A61B42/40
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2209/06 Packaging for specific medical equipment
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.

Claims

1. A microneedle patch applicator system, comprising:

an applicator, comprising;

a housing;

a slidably disposed applicator plate, moveable between a retracted position and a deployed position in a reciprocating manner, the applicator plate having an engaging surface;

a compression spring mounted in such a way that imparts a spring force to the applicator plate when the applicator plate is in the retracted position;

a microneedle patch docking mechanism configured in such a way that the docking mechanism captures and holds a microneedle patch in a position proximal the engaging surface of the applicator plate while the applicator plate is in the retracted position; and

a latch mechanism that when latched holds the applicator plate in place and when unlatched permits the applicator plate to move; and

the microneedle patch disposed on a support;

wherein upon placement of the applicator onto the microneedle patch and the support, application of force to the applicator causes retraction of the applicator plate to the retracted position and capture of the microneedle patch by the docking mechanism.

2. The microneedle patch applicator system of claim 1, wherein the applicator further comprises a trigger mechanism configured in such a way that activation of the trigger mechanism unlatches the latch mechanism.

3. The microneedle patch applicator system of claim 1, wherein when the latch mechanism is in an unlatched position, the applicator plate is capable of retraction to the retracted position in response to a force applied to the applicator.

4. The microneedle patch applicator system of claim 1, wherein unlatching of the latch mechanism when the applicator plate is in the retracted position releases the applicator plate enabling movement from the retracted position to the deployed position with a kinetic energy of between about 0.1 lbf*in and about 10 lbf*in, and preferably between about 1 lbf*in and about 2 lbf*in.

5. The microneedle patch applicator system of claim 1, wherein the applicator deploys the microneedle patch with sufficient force to anchor the microneedle patch to a skin surface with a plurality of microneedles disposed thereon.

6. The microneedle patch applicator system of claim 1, wherein the microneedle patch comprises a plurality of microneedles configured for anchoring the microneedle patch to a skin surface.

7. The microneedle patch applicator system of claim 1, wherein the microneedle patch comprises a plurality of microneedles configured to contain and deliver a bioactive agent upon attaching to a skin surface.

8. The microneedle patch applicator system of claim 1, wherein the microneedle patch is stored in a sterile packaging prior to use in the applicator.

9. The microneedle patch applicator system of claim 1, wherein the microneedle patch is stored together with the support in a sterile packaging prior to use of the microneedle patch in the applicator.

10. The microneedle patch applicator system of claim 1, wherein the microneedle patch contains one or more bioactive agents disposed thereon.

11. The microneedle patch applicator system of claim 1, wherein the support comprises a perimeter defining an internal area.

12. The microneedle patch applicator system of claim 11, wherein an elevated hub is disposed at a location that is substantially at a center point of the internal area.

13. The microneedle patch applicator system of claim 12, wherein the elevated hub comprises a substantially mesa shape with a hollow center at a substantially flat portion of a top of the elevated hub.

14. The microneedle patch applicator system of claim 12, wherein the elevated hub has a hollow center.