Composition comprising and method of using angiopoietin-like protein 3 ANGPTL3
First Claim
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1. A method for the treatment of acute liver disease, comprising administering to a mammalian subject in need by acute mode a therapeutically effective amount of a polypeptide comprising an amino acid sequence having at least 98% sequence identity to the human Angptl3 sequence of SEQ ID NO:
- 2, or an agonist antibody of the polypeptide.
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Abstract
The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.
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8 Claims
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1. A method for the treatment of acute liver disease, comprising administering to a mammalian subject in need by acute mode a therapeutically effective amount of a polypeptide comprising an amino acid sequence having at least 98% sequence identity to the human Angptl3 sequence of SEQ ID NO:
- 2, or an agonist antibody of the polypeptide.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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