Compounds and methods for reversible modification of biologically active molecules
First Claim
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1. An amine-reactive modifying agent represented by the structure consisting of:
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Abstract
The present invention is directed compounds for reversibly modification of biologically active molecules. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
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10 Claims
- 1. An amine-reactive modifying agent represented by the structure consisting of:
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10. A pH labile compound represented by the structure consisting of:
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