Systems and methods for magnetic-assisted therapeutic agent delivery

• US 8,544,474 B2
• Filed: 12/19/2008
• Issued: 10/01/2013
• Est. Priority Date: 12/20/2007
• Status: Active Grant

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Sandhu, Gurpreet S., Holmes, David R. Jr., Simari, Robert D., Sandhu, Nicole P., Holmes, David R. III
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): MCBRIDE, SHANNON CANTY
• Application Number:
  US12/809,197
• Publication Number:
  US 20110144411A1
• Time in Patent Office: 1,747 Days
• Field of Search: 600 9- 15, 600/407, 128897-899, 436/526
• US Class Current: 128/899
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 2/002 in combination with another treatment
• CPC Class Codes: A61N 2/06 using magnetic fields produced by permanent magnets A61N2/12 takes precedence

Abstract

Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.

Claims

1. A system for magnetically-assisted delivery of a therapeutic agent, the system comprising:

a carrier device comprising a carrier surface and first magnetic field generator generating a first magnetic field comprising magnetic flux lines extending through the carrier surface, wherein the first magnetic field comprises a first magnetic field strength at the carrier surface;

a plurality of discrete magnetic particles attracted to the carrier surface by the first magnetic field, wherein the discrete magnetic particles are associated with a therapeutic agent;

a release device comprising a second magnetic field generator generating a second magnetic field comprising magnetic flux lines extending through a release surface of the release device, wherein the second magnetic field comprises a second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 15 centimeters or less from the carrier surface.

2. A system according to claim 1, wherein the second magnetic field generator is capable of generating the second magnetic field such that the second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 5 centimeters or less from the carrier surface.

3. A system according to claim 1, wherein the second magnetic field generator is capable of generating the second magnetic field such that the second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 10 centimeters or less from the carrier surface.

4. A system according to claim 1, wherein the second magnetic field generator is capable of generating the second magnetic field such that the second magnetic field strength at the carrier surface that is greater than the first magnetic field strength at the carrier surface when the release surface is located a distance of 2 centimeters or less from the carrier surface.

5. A system according to claim 1, wherein the first magnetic field generator comprises magnetic material that generates a static magnetic field.

6. A system according to claim 1, wherein the first magnetic field generator comprises an electromagnet.

7. A system according to claim 1, wherein the second magnetic field generator comprises magnetic material that generates a static magnetic field.

8. A system according to claim 1, wherein the second magnetic field generator comprises an electromagnet.

9. A system according to claim 1, wherein the first magnetic field generator comprises permanently magnetized material and wherein the second magnetic field generator comprises an electromagnet.

10. A system according to claim 9, wherein the second magnetic field generator comprises a controller, wherein the controller changes the second magnetic field strength.

11. A system according to claim 9, wherein the second magnetic field generator comprises a controller, wherein the controller changes the second magnetic field strength according to a predetermined protocol.

12. A method of delivering a therapeutic agent, the method comprising:

positioning a carrier surface of a carrier device proximate selected internal tissue, wherein magnetic flux lines of a selected magnetic pole of a first magnetic field extend through the carrier surface;

magnetically retaining a therapeutic agent to the carrier surface, wherein the therapeutic agent is associated with a plurality of magnetic particles;

positioning a release device that comprises a release surface proximate the selected internal tissue, wherein the selected internal tissue is located between the release surface and the carrier surface, and wherein the release device comprises a second magnetic field generator generating a second magnetic field that extends through the release surface and towards the carrier surface; and

delivering at least a portion of the therapeutic substance to the selected internal tissue by magnetically attracting at least a portion of the plurality of magnetic particles towards the release surface;

wherein, proximate the carrier surface, the second magnetic field has a magnetic field strength greater than a magnetic field strength of the first magnetic field;

and wherein the second magnetic field extending through the release surface comprises a magnetic pole facing the carrier device that is the same as the selected magnetic pole of the carrier device.

13. A method according to claim 12, wherein the method further comprises changing the second magnetic field strength after positioning the carrier surface proximate selected internal tissue.

14. A method according to claim 12, wherein the method further comprises reversing the magnetic pole of the second magnetic field after positioning the carrier surface proximate selected internal tissue.

15. A method according to claim 12, wherein the method further comprises reversing the magnetic pole of the second magnetic field three or more times while the selected tissue is located between the carrier surface and release surface.

16. A method according to claim 12, wherein the first magnetic field strength is substantially constant at the carrier surface.

17. A method according to claim 12, wherein the method further comprises reducing the magnetic field strength of the first magnetic field extending through the carrier surface after positioning the carrier surface proximate the selected internal tissue.

18. A method according to claim 12, wherein the method further comprises terminating the first magnetic field after positioning the carrier surface proximate selected internal tissue.

19. A method according to claim 12, wherein the first magnetic field is generated by magnetic material that generates a static magnetic field.

20. A method according to claim 12, wherein the second magnetic field is generated by magnetic material that generates a static magnetic field.