Patch-sized fluid delivery systems and methods
First Claim
1. Apparatus comprising:
- a patch-sized housing including a reusable portion and a disposable portion that is removably engageable with the reusable portion;
wherein;
the disposable portion includes a substrate having flexible membrane material thereon and incorporating therein a fluid channel, the fluid channel being part of a fluid path in the disposable portion from a reservoir port to a cannula port and including a series of regions exposed to the flexible membrane material, at least one of such regions being a valve region; and
the reusable portion includes a control assembly having an active mechanical assembly that interacts mechanically with the regions through the membrane material in such a manner as to achieve pumping of fluid along the fluid path, the active mechanical assembly including a valve actuator operating on the valve region.
1 Assignment
0 Petitions
Accused Products
Abstract
A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.
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Citations
133 Claims
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1. Apparatus comprising:
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a patch-sized housing including a reusable portion and a disposable portion that is removably engageable with the reusable portion;
wherein;the disposable portion includes a substrate having flexible membrane material thereon and incorporating therein a fluid channel, the fluid channel being part of a fluid path in the disposable portion from a reservoir port to a cannula port and including a series of regions exposed to the flexible membrane material, at least one of such regions being a valve region; and the reusable portion includes a control assembly having an active mechanical assembly that interacts mechanically with the regions through the membrane material in such a manner as to achieve pumping of fluid along the fluid path, the active mechanical assembly including a valve actuator operating on the valve region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101)
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2. Apparatus according to claim 1, wherein the series of regions are exposed to a single flexible membrane of the flexible membrane material.
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3. Apparatus according to claim 1, wherein the fluid path includes a fluid impedance downstream of the regions so as to prevent pumping of fluid along the path at an unsafe flow rate.
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4. Apparatus according to claim 3, wherein the fluid impedance is a passive fluid impedance.
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5. Apparatus according to claim 3, wherein the fluid impedance includes a tortuous conduit.
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6. Apparatus according to claim 5, wherein the conduit is an integral part of the fluid channel.
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7. Apparatus according to claim 5, wherein the conduit comprises coiled tubing.
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8. Apparatus according to claim 7, wherein the coiled tubing includes at least two turns.
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9. Apparatus according to claim 5, wherein the conduit has a serpentine shape.
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10. Apparatus according to claim 5, wherein the conduit has a length greater than 2 cm.
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11. Apparatus according to claim 5, wherein the conduit has a length greater than a largest dimension of the housing.
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12. Apparatus according to claim 5, wherein the conduit includes an effective internal diameter selected to provide a predetermined impedance based on at least one of a viscosity and a density of the fluid.
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13. Apparatus according to claim 5, wherein the conduit includes a length selected to provide a predetermined impedance based on at least one of a viscosity and a density of the fluid.
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14. Apparatus according to claim 5, wherein the internal diameter of the conduit is sufficiently large to prevent occlusion due to flow of a therapeutic liquid through the conduit.
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15. Apparatus according to claim 1, wherein the substrate includes a dispensing chamber formed in the fluid channel of the substrate, such chamber bounded by flexible membrane material forming a dispensing chamber membrane.
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16. Apparatus according to claim 15, wherein the fluid channel includes a finite fluid impedance downstream of the dispensing chamber, the fluid impedance sufficiently high so as to cause the expansion of the dispensing chamber membrane in response to the pumping of fluid induced by the active mechanical assembly.
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17. Apparatus according to claim 16, wherein the control assembly includes at least a first pump mode in which the dispensing chamber is permitted to substantially empty between pump strokes and a second pump mode in which the dispensing chamber is not permitted to fully empty between pump strokes.
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18. Apparatus according to claim 16, wherein the reusable portion includes a resilient dispensing spring positioned atop the dispensing chamber membrane to facilitate contraction of the dispensing chamber membrane.
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19. Apparatus according to claim 18, wherein the dispensing spring includes one of a spiral shape, a fan shape, and multiple helical grooves.
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20. Apparatus according to claim 16, wherein the dispensing chamber membrane includes a resilient dispensing spring to facilitate contraction of the dispensing chamber membrane.
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21. Apparatus according to claim 15, wherein the control assembly includes a fluid sensor in communication with the dispensing chamber for measuring fluid flow through the dispensing chamber.
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22. Apparatus according to claim 21, wherein the fluid sensor is an acoustic volume sensor.
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23. Apparatus according to claim 22, wherein the acoustic volume sensor includes a loudspeaker, and wherein the loudspeaker is used by the control assembly for both acoustic volume sensing and audible alarm generation.
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24. Apparatus according to claim 22, wherein the acoustic volume sensor includes a microphone, and wherein the microphone is used by the control assembly for both acoustic volume sensing and monitoring pump operation.
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25. Apparatus according to claim 1, wherein the disposable portion further includes a pump region, and wherein the active mechanical assembly further includes a pump actuator operating on the pump region.
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26. Apparatus according to claim 25, wherein the active mechanical assembly further includes a motor for operation of at least one of the valve actuator and the pump actuator under control of the control assembly.
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27. Apparatus according to claim 26, wherein the active mechanical assembly includes a plate coupled to the valve actuator, the pump actuator, and the motor for coordinated operation of the valve actuator and the pump actuator.
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28. Apparatus according to claim 27, wherein the valve region is positioned between the reservoir port and the pump region, and wherein operation of the valve actuator and the pump actuator is coordinated so as to prevent backflow of fluid toward the reservoir port.
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29. Apparatus according to claim 26, wherein the motor includes a shape-memory actuator.
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30. Apparatus according to claim 29, wherein the motor includes at least one pulley for folding the shape-memory actuator to fit within the reusable portion.
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31. Apparatus according to claim 29, wherein the shape-memory actuator is operated through changes in heat, and wherein the motor includes a heater for operating the shape-memory actuator.
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32. Apparatus according to claim 29, wherein the shape-memory actuator is operated through changes in electrical current passed through at least a portion of the shape-memory actuator.
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33. Apparatus according to claim 32, wherein the shape-memory actuator is electrically coupled so as to provide a plurality of electrical paths of different lengths through the shape-memory actuator.
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34. Apparatus according to claim 33, wherein a shorter electrical path is used during normal operation of a pump and a longer electrical path is used during priming and air-purging of the pump.
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35. Apparatus according to claim 26, wherein the motor includes a plurality of shape-memory actuators.
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36. Apparatus according to claim 35, wherein the plurality of shape-memory actuators provide for redundant operation of the active mechanical assembly.
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37. Apparatus according to claim 35, wherein different numbers of shape-memory actuators are used to provide different actuation forces or stroke lengths.
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38. Apparatus according to claim 35, wherein the plurality of shape-memory actuators includes shape-memory actuators of at least two different lengths.
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39. Apparatus according to claim 38, wherein a shorter shape-memory actuator is used during normal operation of a pump and a longer shape-memory actuator is used during priming and air-purging of the pump.
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40. Apparatus according to claim 35, wherein the plurality of shape-memory actuators includes shape-memory actuators of at least two different gauges.
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41. Apparatus according to claim 1, wherein the substrate and the flexible membrane material of the disposable portion constitute a fluidic assembly, and wherein the disposable portion further includes a disposable base into which the fluidic assembly fits.
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42. Apparatus according to claim 41, further comprising an adhesive pad coupled to a bottom of the disposable base.
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43. Apparatus according to claim 1, wherein the reservoir port includes a reservoir interface for coupling with a fluid reservoir.
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44. Apparatus according to claim 43, wherein the reservoir interface includes a cannulated needle for introduction into the fluid reservoir so as to provide fluid communication between the fluid reservoir and the fluid path.
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45. Apparatus according to claim 43, wherein the reservoir interface includes a septum for penetration by a fluid reservoir cannulated needle so as to provide fluid communication between the fluid reservoir and the fluid path.
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46. Apparatus according to claim 1, wherein at least one of the reusable portion and the disposable portion includes a recess for receiving a fluid reservoir.
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47. Apparatus according to claim 46, wherein the fluid reservoir is eccentrically shaped, and wherein the recess is similarly shaped so as to prevent incorrect orientation of the fluid reservoir within the housing.
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48. Apparatus according to claim 1, wherein the reusable portion and the disposable portion include a latching mechanism for permitting selective engagement and disengagement of the reusable and disposable portions.
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49. Apparatus according to claim 48, wherein the reusable portion includes at least one latch actuator for permitting selective coupling and decoupling of the reusable and disposable portions.
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50. Apparatus according to claim 1, wherein the control assembly includes an electrical power source for providing electrical power to electronics in at least one of the reusable portion and the disposable portion.
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51. Apparatus according to claim 50, wherein the electrical power source is a rechargeable battery.
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52. Apparatus according to claim 51, wherein the control assembly further includes a battery recharging circuit for recharging the battery.
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53. Apparatus according to claim 52, wherein the control assembly further includes a coil for inductively coupling the battery recharging circuit with an external power source for recharging the rechargeable battery.
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54. Apparatus according to claim 50, wherein the control assembly further includes a backup electrical power source.
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55. Apparatus according to claim 54, wherein the backup electrical power source includes at least one of a battery and a supercapacitor.
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56. Apparatus according to claim 1, wherein the disposable portion includes an electrical power source for providing electrical power to electronics in at least one of the reusable portion and the disposable portion.
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57. Apparatus according to claim 56, wherein the electrical power source includes at least one of a battery and a supercapacitor.
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58. Apparatus according to claim 1, wherein the control assembly further includes a network interface for communication with a remote controller.
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59. Apparatus according to claim 58, wherein the network interface includes a wireless transceiver for wireless communication with the remote controller.
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60. Apparatus according to claim 59, wherein the control assembly further includes a coil coupled to the wireless transceiver for conveying radio frequency signals to and from the wireless transceiver.
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61. Apparatus according to claim 60, wherein the control assembly further includes a battery recharging circuit for recharging a rechargeable battery, wherein the coil is further coupled to the battery recharging circuit for inductively coupling the battery recharging circuit with an external power source.
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62. Apparatus according to claim 58, wherein the network interface includes a communication interface for wired communication with the remote controller.
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63. Apparatus according to claim 58, wherein the control assembly receives configuration information from the remote controller and sends status information to the remote controller via the network interface.
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64. Apparatus according to claim 1, further comprising a speaker disposed in one of the reusable portion and the disposable portion for audible alarm generation.
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65. Apparatus according to claim 1, further comprising a vibrating mechanism disposed in the reusable portion for at least one of audible and tactile alarm generation.
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66. Apparatus according to claim 1, further comprising a vibrating mechanism disposed in the disposable portion for at least one of audible alarm generation, tactile alarm generation, and insertion of a needle.
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67. Apparatus according to claim 1, further comprising a microphone disposed in one of the reusable portion and the disposable portion for monitoring operation of the active mechanical assembly.
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68. Apparatus according to claim 1, further comprising a temperature sensor disposed in one of the reusable portion and the disposable portion for providing temperature information to the control assembly.
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69. Apparatus according to claim 68, wherein the temperature sensor is one of an ambient temperature sensor and a skin temperature sensor.
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70. Apparatus according to claim 1, wherein the control assembly is operably coupled to generate an alarm to indicate an operational condition.
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71. Apparatus according to claim 70, wherein the alarm includes at least one of an audible alarm, a visual alarm, a tactile alarm, and a wireless alarm signal.
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72. Apparatus according to claim 70, wherein the operational condition includes at least one of a power on condition, proper operation of the control assembly, and proper delivery of fluid within a predetermined set of parameters.
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73. Apparatus according to claim 1, wherein the control assembly is operably coupled to generate an alarm to indicate a fault condition.
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74. Apparatus according to claim 73, wherein the alarm includes at least one of an audible alarm, a visual alarm, a tactile alarm, and a wireless alarm signal.
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75. Apparatus according to claim 73, wherein the fault condition includes at least one of a low power level, a low fluid level, an abnormal temperature level, a problem with a primary or backup power supply, detection of an occlusion, detection of an air bubble, detection of a fluid leak, decoupling of the reusable portion and the disposable portion, communication failure between the reusable portion and the disposable portion, expiration of the disposable portion, attempted re-use of the disposable portion, detection of abnormal vibration from the pump, and detection of lack of vibration from the pump.
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76. Apparatus according to claim 1, wherein the disposable portion includes a processor for at least one of continuing device operation in the event of a failure, generating an alarm to indicate that a failure has occurred, and providing status information to the control assembly.
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77. Apparatus according to claim 76, wherein the status information includes at least one of operational history of the disposable portion, characteristics of the disposable portion, and usage information.
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78. Apparatus according to claim 76, wherein the control assembly is operably coupled to selectively prevent operation of the active mechanical assembly and generate an alarm based on the status information received from the processor.
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79. Apparatus according to claim 1, wherein the control assembly includes a user input, operable from outside of the housing, for actuating the mechanical assembly to deliver a predetermined quantity of fluid.
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80. Apparatus according to claim 79, wherein the predetermined quantity is programmable.
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81. Apparatus according to claim 79, wherein the predetermined quantity is delivered as a single bolus.
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82. Apparatus according to claim 79, wherein the predetermined quantity is delivered as a plurality of pulses.
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83. Apparatus according to claim 79, wherein the user input includes a manual control, accessible from outside of the housing, for manual actuation of the mechanical assembly.
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84. Apparatus according to claim 79, wherein the user input includes a network interface for remote actuation of the mechanical assembly from a remote controller.
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85. Apparatus according to claim 79, wherein the control assembly is operably coupled to generate an alert upon attempted actuation of the mechanical assembly via the user input and to require a user confirmation before actuating the mechanical assembly to deliver the predetermined quantity of fluid.
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86. Apparatus according to claim 85, wherein the alert includes at least one of an audible alert, a visual alert, a tactile alert, and a query provided from a remote controller.
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87. Apparatus according to claim 79, wherein the control assembly is operably coupled to generate an alert after completing delivery of the predetermined quantity of fluid.
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88. Apparatus according to claim 1, wherein the disposable portion is configured to support a cannulus in fluid communication with the fluid path and an analyte sensor in communication with the control assembly.
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89. Apparatus according to claim 88, wherein interconnection between the control assembly and the analyte sensor is established upon engagement of the reusable portion and the disposable portion.
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90. Apparatus according to claim 89, wherein the control assembly includes an analyte sensor interface for direct interconnection with the analyte sensor.
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91. Apparatus according to claim 1, further comprising at least one pad for situation between an underside of the disposable portion and a patient'"'"'s skin so as to provide separation between the disposable portion and a patient'"'"'s skin.
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92. Apparatus according to claim 91, wherein the at least one pad is secured to the underside of the disposable portion.
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93. Apparatus according to claim 92, wherein the at least one pad includes adhesive for securing the disposable portion to the patient'"'"'s skin.
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94. Apparatus according to claim 91, wherein the at least one pad is placed loosely between the underside of the disposable portion and the patient'"'"'s skin.
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95. Apparatus according to claim 91, wherein the at least one pad is configured to provide for air flow to a portion of the patient'"'"'s skin covered by the disposable portion when placed on the patient.
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96. Apparatus according to claim 95, wherein air flow is provided by at least one of passageways through the pad, passageways between pads, and construction of the at least one pad from a porous material.
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97. Apparatus according to claim 1, further comprising an adhesion system for affixation of the housing to a human body, the system comprising:
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a first set of three or more members, each member including an adhesive material on at least one side so as to attach to the body upon application of pressure, the members disposed around a central region; and a second set of three or more members, each member including an adhesive material on at least one side so as to attach to the body upon application of pressure, the members disposed around the central region, wherein the members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and wherein the members of the second set spaced to allow members of the first set to detach from the body without detaching the members of the second set.
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98. Apparatus according to claim 97, wherein at least one member is perforated so as to allow facile tearing off of the member.
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99. Apparatus according to claim 97, further including at least one peelable backing strip.
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100. Apparatus according to claim 97, wherein the members of the first set are a first color and the members of the second set are a second color different from the first color.
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101. Apparatus according to claim 1, further comprising a plurality of tethers coupled to the housing and a plurality of adhesive members for securing the tethers to a patient'"'"'s skin.
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2. Apparatus according to claim 1, wherein the series of regions are exposed to a single flexible membrane of the flexible membrane material.
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102. A disposable unit for a patch-sized fluid delivery device, the disposable unit removably engageable with a corresponding reusable unit, the disposable unit including a substrate having flexible membrane material thereon and incorporating therein a fluid channel, the fluid channel being part of a fluid path in the disposable unit from a reservoir port to a cannula port and including a series of regions exposed to the flexible membrane material, at least one of such regions being a valve region, so that an active mechanical assembly in the reusable portion can interact mechanically with the regions through the membrane material in such a manner as to achieve pumping of fluid along the fluid path, the active mechanical assembly including a valve actuator operating on the valve region.
- View Dependent Claims (103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117)
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103. A disposable unit according to claim 102, wherein the series of regions are exposed to a single flexible membrane of the flexible membrane material.
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104. A disposable unit according to claim 102, further including a fluid impedance in the fluid path downstream of the regions to as to prevent pumping of fluid along the fluid path at an unsafe flow rate.
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105. A disposable unit according to claim 104, wherein the fluid impedance includes at least one of a tortuous conduit that is an integral part of the fluid channel and tubing that is in fluid communication with the fluid channel.
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106. A disposable unit according to claim 102, wherein the substrate includes a dispensing chamber formed in the fluid channel of the substrate, such chamber bounded by flexible membrane material forming a dispensing chamber membrane.
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107. A disposable unit according to claim 106, wherein the dispensing chamber membrane includes a resilient dispensing spring to facilitate contraction of the dispensing chamber membrane.
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108. A disposable unit according to claim 102, further including a pump region for operation by a corresponding pump actuator in the reusable unit through the flexible membrane material.
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109. A disposable unit according to claim 102, wherein the substrate and the flexible membrane material constitute a fluidic assembly, and wherein the disposable unit further includes a disposable base into which the fluidic assembly fits.
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110. A disposable unit according to claim 109, further comprising an adhesive pad coupled to a bottom of the disposable base.
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111. A disposable unit according to claim 102, wherein the reservoir port includes a reservoir interface for coupling with a fluid reservoir, the reservoir port including one of a needle for introduction into the fluid reservoir and a septum for penetration by a fluid reservoir needle so as to provide fluid communication between the fluid reservoir and the fluid path.
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112. A disposable unit according to claim 102, further including a latching mechanism for permitting selective engagement and disengagement with the reusable unit.
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113. A disposable unit according to claim 102, further including an electrical power source for providing electrical power to electronics in at least one of the reusable unit and the disposable unit.
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114. A disposable unit according to claim 102, further including at least one output selected from the group consisting of an audible output, a visual output, a tactile output, and a wireless output.
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115. A disposable unit according to claim 102, configured for at least one of inserting and supporting a cannulus for fluid communication with the fluid path and an analyte sensor for communication with a control assembly of the reusable unit.
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116. A disposable unit according to claim 102, further including a mechanism for attaching the disposable unit to a patient.
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117. A disposable unit according to claim 116, further including a processor for at least one of continuing device operation in the event of a failure, generating an alarm to indicate that a failure has occurred, and providing status information to the reusable portion.
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103. A disposable unit according to claim 102, wherein the series of regions are exposed to a single flexible membrane of the flexible membrane material.
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118. A reusable unit for a patch-sized fluid delivery device, the reusable unit removably engageable with a corresponding disposable unit including a substrate having a flexible material thereon and incorporating a fluid channel, the reusable unit including a control assembly having an active mechanical assembly that interacts mechanically with regions of the fluid channel in the substrate, including a valve region, through the flexible membrane material in such a manner as to achieve pumping of fluid along a fluid path including the fluid channel, the active mechanical assembly including a valve actuator for operating on the valve region.
- View Dependent Claims (119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133)
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119. A reusable unit according to claim 118, wherein the disposable unit includes a dispensing chamber bounded by flexible membrane material, and wherein the reusable unit includes a fluid sensor for communication with the dispensing chamber for measuring fluid flow through the dispensing chamber.
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120. A reusable unit according to claim 119, further including a resilient dispensing spring positioned so as to facilitate contraction of the dispensing chamber membrane.
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121. A reusable unit according to claim 119, wherein the fluid sensor is an acoustic volume sensor.
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122. A reusable unit according to claim 121, wherein the acoustic volume sensor includes a loudspeaker, and wherein the loudspeaker is used by the control assembly for both acoustic volume sensing and audible alarm generation.
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123. A reusable unit according to claim 121, wherein the acoustic volume sensor includes a microphone, and wherein the microphone is used by the control assembly for both acoustic volume sensing and monitoring pump operation.
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124. A reusable unit according to claim 118, wherein the disposable unit includes a pump region bounded by flexible membrane material, and wherein the reusable unit includes a pump actuator for operating on the pump region through the flexible membrane material.
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125. A reusable unit according to claim 124, wherein the active mechanical assembly further includes a motor for operation of at least one of the valve actuator and the pump actuator under control of the control assembly, the motor including at least one shape-memory actuator.
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126. A reusable unit according to claim 118, further including a latching mechanism for permitting selective engagement and disengagement with the disposable unit.
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127. A reusable unit according to claim 118, wherein the control assembly includes at least one electrical power source for providing electrical power to electronics in at least one of the reusable unit and the disposable unit.
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128. A reusable unit according to claim 127, wherein the control assembly further includes a battery recharging circuit for recharging a battery and a mechanism for providing electrical power to the battery recharging circuit.
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129. A reusable unit according to claim 118, wherein the control assembly further includes a network interface for communication with a remote controller.
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130. A reusable unit according to claim 118, wherein the control assembly further includes at least one alarm output selected from the group consisting of an audible output, a visual output, a tactile output, and a wireless output.
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131. A reusable unit according to claim 118, wherein the control assembly further includes a temperature sensor capable of sensing at least one of ambient temperature and skin temperature.
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132. A reusable unit according to claim 118, wherein the control assembly includes a user input for user actuation of the mechanical assembly to deliver a predetermined quantity of fluid.
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133. A reusable unit according to claim 118, wherein the control assembly is operably coupled to selectively prevent operation of the active mechanical assembly and generate an alarm based on a status of the disposable portion.
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119. A reusable unit according to claim 118, wherein the disposable unit includes a dispensing chamber bounded by flexible membrane material, and wherein the reusable unit includes a fluid sensor for communication with the dispensing chamber for measuring fluid flow through the dispensing chamber.
Specification
- Resources
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Current AssigneeDeka Products Limited Partnership
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Original AssigneeDeka Products Limited Partnership
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InventorsKamen, Dean, Gray, Larry B., Beavis, Russell H.
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Primary Examiner(s)Lucchesi, Nicholas
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Assistant Examiner(s)Chander, Diva K
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Application NumberUS11/704,886Publication NumberTime in Patent Office2,426 DaysField of Search604/131, 604/151, 604/216, 604/506US Class Current604/131CPC Class CodesA61B 2560/0412 Low-profile patch shaped ho...A61B 5/0024 for multiple sensor units a...A61B 5/1427 Multiple blood sampling, e....A61B 5/150022 for capillary blood or inte...A61B 5/150175 Adjustment of penetration d...A61B 5/150358 Strips for collecting blood...A61B 5/150389 Hollow piercing elements, e...A61B 5/150503 Single-ended needles hollow...A61B 5/15107 Piercing being assisted by ...A61B 5/15117 comprising biased elements,...A61B 5/15119 comprising shape memory alloysA61B 5/15121 comprising piezosA61B 5/15123 comprising magnets or solen...A61B 5/15125 comprising a vacuum or comp...A61B 5/15186 Devices loaded with a singl...A61B 5/6833 Adhesive patchesA61J 1/20 Arrangements for transferri...A61M 2005/1402 PrimingA61M 2005/14208 with a programmable infusio...A61M 2005/14252 with needle insertion meansA61M 2005/14268 : with a reusable and a dispo...A61M 2005/14506 : mechanically driven, e.g. s...A61M 2005/1581 : Right-angle needle-type dev...A61M 2005/1583 : Needle extractorsA61M 2005/1585 : Needle insertersA61M 2005/1586 : Holding accessories for hol...A61M 2005/16863 : Occlusion detectionA61M 2005/1726 : the body parameters being m...A61M 2205/0266 : Shape memory materialsA61M 2205/0294 : Piezoelectric materialsA61M 2205/04 : implantedA61M 2205/16 : with back-up system in case...A61M 2205/18 : with alarmA61M 2205/3303 : Using a biosensorA61M 2205/3331 : Pressure; FlowA61M 2205/3334 : Measuring or controlling th...A61M 2205/3337 : Controlling, regulating pre...A61M 2205/3341 : stabilising pressure or flo...A61M 2205/3368 : TemperatureA61M 2205/3375 : Acoustical, e.g. ultrasonic...A61M 2205/3379 : Masses, volumes, levels of ...A61M 2205/3389 : Continuous level detection ...A61M 2205/3523 : using telemetric meansA61M 2205/3546 : RangeA61M 2205/3569 : sublocal, e.g. between cons...A61M 2205/3576 : with non implanted data tra...A61M 2205/3592 : using telemetric means, e.g...A61M 2205/50 : with microprocessors or com...A61M 2205/502 : User interfaces, e.g. scree...A61M 2205/52 : with memories providing a h...A61M 2205/581 : by audible feedbackA61M 2205/582 : by tactile feedbackA61M 2205/583 : by visual feedbackA61M 2205/8206 : battery-operatedA61M 2205/8237 : Charging meansA61M 2206/22 : eliminating pulsatile flows...A61M 2207/00 : Methods of manufacture, ass...A61M 2209/045 : for filling, e.g. for filli...A61M 2230/201 : Glucose concentrationA61M 5/141 : with capillaries for restri...A61M 5/1413 : Modular systems comprising ...A61M 5/142 : Pressure infusion, e.g. usi...A61M 5/14212 : Pumping with an aspiration ...A61M 5/14216 : Reciprocating piston typeA61M 5/14224 : Diaphragm typeA61M 5/14232 : Roller pumpsA61M 5/14244 : adapted to be carried by th...A61M 5/14248 : of the skin patch typeA61M 5/1452 : pressurised by means of pis...A61M 5/14586 : pressurised by means of a f...A61M 5/148 : flexible, e.g. independent ...A61M 5/152 : pressurised by contraction ...A61M 5/158 : Needles for infusions; Acce...A61M 5/162 : Needle sets, i.e. connectio...A61M 5/168 : Means for controlling media...A61M 5/16804 : Flow controllersA61M 5/16809 : by repeated filling and emp...A61M 5/16813 : by controlling the degree o...A61M 5/16831 : Monitoring, detecting, sign...A61M 5/16886 : for measuring fluid flow ra...A61M 5/172 : electrical or electronic A6...A61M 5/1723 : using feedback of body para...A61M 5/3287 : Accessories for bringing th...A61M 5/365 : Air detectors A61M5/1684 ta...A61M 5/5086 : for indicating if defective...B23P 15/00 : Making specific metal objec...F04B 43/02 : having plate-like flexible ...F04B 43/09 : Pumps having electric driveF04B 43/1253 : by using two or more roller...F04B 7/00 : Piston machines or pumps ch...F04C 2230/60 : Assembly methodsG01F 22/00 : Methods or apparatus for me...G05B 23/02 : Electric testing or monitoringG05D 7/0647 : the plurality of throttling...G05D 7/0676 : by action on flow sources G...G08C 17/02 : using a radio linkH04B 7/2609 : Arrangements for range cont...Y10T 29/49236 : Fluid pump or compressor ma...Y10T 29/494 : Fluidic or fluid actuated d...Y10T 29/49412 : with assembly, disassembly ...Y10T 29/49826 : Assembling or joiningY10T 29/49828 : Progressively advancing of ...