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Multiple reservoir implantable drug infusion device and method

  • US 8,545,477 B2
  • Filed: 10/22/2008
  • Issued: 10/01/2013
  • Est. Priority Date: 03/05/2008
  • Status: Active Grant
First Claim
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1. A method of independently introducing infusate into an accumulator from at least two separate infusate sources, comprising:

  • providing an implatable pressure chamber that contains a fluid having positive vapor pressure at normal body temperature;

    providing a first infusate reservoir in said pressure chamber, said first infusate reservoir adapted to contain a first infusate at a constant pressure of the pressure chamber;

    providing an additional infusate reservoir in said pressure chamber, said additional infusate reservoir adapted to contain an additional infusate at a constant pressure of the pressure chamber, wherein the additional infusate reservoir is oppositely disposed to the first infusate reservoir in the pressure chamber;

    providing a metering assembly consisting essentially of a fixed volume accumulator having an inlet in fluid communication with said first infusate reservoir via a first valve and in fluid communication with said additional infusate reservoir via an additional valve, and an outlet valve in communication with an outlet of said accumulator, said accumulator comprising a chamber housing a flexible diaphragm that provides a barrier between a gas portion of the chamber and an infusate portion of the chamber;

    introducing said first infusate into said first infusate reservoir to cause the first reservoir to expand in a first direction;

    introducing said additional infusate into said additional infusate reservoir to cause the additional infusate reservoir to expand in a second direction opposite the first direction;

    introducing said first infusate from said first infusate reservoir independent of said additional infusate into said infusate portion of said accumulator by opening said first valve while said additional valve and said outlet valve are in a closed position;

    emptying said accumulator of said first infusate by opening said outlet valve while said first and additional valves are closed;

    introducing said additional infusate from said additional infusate reservoir into said infusate portion of said accumulator by opening said additional valve while said first valve and said outlet valve are in a closed position; and

    emptying said additional infusate from said accumulator by opening said outlet valve while said first and additional valves are in a closed position.

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