Tissues patches and related delivery systems and methods

• US 8,545,482 B2
• Filed: 10/10/2011
• Issued: 10/01/2013
• Est. Priority Date: 05/05/2003
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Pugsley, Charles H, McBride-Sakal, Marci
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US13/269,821
• Publication Number:
  US 20120071988A1
• Time in Patent Office: 722 Days
• Field of Search: 604/96.01, 604/103.05, 604/103.14, 604/104, 604/906, 604/910, 604/912, 604/915, 604/522, 623/14.13, 623/23.7, 623/23.74, 623/23.75, 623/23.76
• US Class Current: 604/890.1
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/0213 the fluid retention member being a layer of hydrocolloid, gel forming material
• CPC Class Codes: A61F 13/0226 characterised by the support layer
• CPC Class Codes: A61F 13/0253 characterized by the adhesive material
• CPC Class Codes: A61L 15/40 containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body

Abstract

Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A system for delivering a tissue implant includes a catheter having an expandable member at a distal end portion, a carrier placed around the expandable member, and the carrier configured to expand from a contracted state to an expanded state and to receive the tissue implant. The tissue implant contacts the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state.

Claims

1. A system for delivering a tissue patch to a lesion in an alimentary tract of a patient, comprising:

a catheter having an expandable member at a distal end portion; and

a carrier having an outer surface and an inner surface and placed around the expandable member, the carrier configured to expand from a contracted state to an expanded state, wherein the carrier either (a) constitutes the tissue patch or (b) supports the tissue patch,

wherein the tissue patch comprises a tissue implant embedded in a substrate and

wherein the tissue patch contacts and adheres to the lesion of the alimentary tract when the expandable member expands the carrier to the expandable state.

2. A system according to claim 1, further comprising a retractable sleeve surrounding the carrier to protect the carrier during insertion and placement of the catheter, the sleeve configured to retract from around the carrier prior to the expandable member expanding to the expanded state.

3. A system according to claim 1, wherein the carrier is formed of a plurality of sections which are configured to be folded in the contracted state.

4. A system according to claim 3, wherein the carrier constitutes the tissue patch.

5. A system according to claim 4, wherein the tissue implant is embedded in the substrate in a form of a cellular suspension.

6. A system according to claim 3, wherein the tissue patch is placed on the outer surface of the carrier and configured to be folded together with the plurality of sections in the contracted state.

7. A system according to claim 6, wherein the tissue implant is embedded in a substrate to form said tissue patch on the outer surface of the carrier.

8. A system according to claim 7, wherein the substrate is a bio-absorbable gel.

9. A system according to claim 7, wherein the carrier is configured to be peeled away from the tissue patch once the tissue patch is securely placed.

10. A system according to claim 3, wherein at least one of the plurality of panels comprises bio-adhesive material.

11. A system according to claim 1, wherein the carrier is made of bio-absorbable material which dissolves over a period of time.

12. A system according to claim 1, wherein the tissue implant is an engineered tissue.

13. A system according to claim 1, wherein the carrier is folded when in said contracted state or wherein the carrier is a sheet wrapped around the expandable member such that the ends overlap when in said contracted state.

14. A system according to claim 13, wherein the carrier comprises a first surface comprising a bio-adhesive material.

15. A system according to claim 14, wherein the carrier comprises a second surface comprising a non-stick material such that said bio-adhesive material contacts said non-stick material when said carrier is in said contracted state.

16. A system according to claim 15, wherein the carrier does not comprise a stent.

17. A system according to claim 14, wherein the carrier does not comprise a stent.

18. A system according to claim 13, wherein the carrier does not comprise a stent.

19. A system according to claim 1, wherein the carrier comprises a first surface comprising a bio-adhesive material.

20. A system according to claim 19, wherein the carrier comprises a second surface comprising a non-stick material such that said bio-adhesive material contacts said non-stick material when said carrier is in said contracted state.

21. A system according to claim 20, wherein the carrier does not comprise a stent.

22. A system according to claim 19, wherein the carrier does not comprise a stent.

23. A system according to claim 1, wherein the carrier does not comprise a stent.